Is acetylcholinesterase a Mg-dependent enzyme?

Chuck Miller rellim at MAILHOST.TCS.TULANE.EDU
Tue Mar 3 10:34:22 EST 1998


Julia Laylander (jlayland at XMISSION.COM) asked "Is acetylcholinesterase a
Mg-dependent enzyme?"

Julia, as you may know, there are several enzymes with acetylcholinesterase
activity. A quick (and free) search of Medline
(http://www.ncbi.nlm.nih.gov/PubMed/) using keywords acetylcholinesterase
AND magnesium gave these (and many more) references. Happy hunting.

 Rodriguez-Ithurralde D, et al.           [See Related Articles]
       Glycine effects on glutamate-receptor elicited acetylcholinesterase
release from slices and synaptosomes of the
       spinal ventral horn.
       J Neurol Sci. 1996 Aug; 139 Suppl: 76-82.
       PMID: 8899663; UI: 97055376.

     Nery da Matta A, et al.           [See Related Articles]
       Effect of Mg(2+)-ATP on acetylcholinesterase of Electrophorus
electricus (L.).
       Z Naturforsch [C]. 1996 Jan; 51(1-2): 65-69.
       PMID: 8721214; UI: 96342218.

     Johnson G, et al.           [See Related Articles]
       Acetylcholinesterase of human intestinal tissue affected by
Hirschsprung's disease: effect of magnesium
       chloride on isoforms.
       Clin Chim Acta. 1995 Dec 29; 243(2): 115-128.
       PMID: 8747488; UI: 96340743.

     Rodriguez-Ithurralde D, et al.           [See Related Articles]
       Glutamate-receptor elicited acetylcholinesterase release in mouse
spinal cord slice: a model of early excitotoxic
       injury.
       J Neurol Sci. 1995 May; 129 Suppl: 104-106.
       PMID: 7595597; UI: 96059159.

     Inestrosa NC, et al.           [See Related Articles]
       Sensitivity of acetylcholinesterase molecular forms to inhibition by
high MgCl2 concentration.
       Biochim Biophys Acta. 1994 Oct 19; 1208(2): 286-293.
       PMID: 7947960; UI: 95035029.

     Szabolcs M, et al.           [See Related Articles]
       Enzymatic properties, metal composition and SH-group reactivity of
the light and heavy sarcoplasmic
       reticulum vesicles.
       Acta Physiol Hung. 1994; 82(2): 153-162.
       PMID: 7887175; UI: 95193533.

     Molnar J, et al.           [See Related Articles]
       Effects of tricyclic compounds on membrane binding of bivalent
cations, activities of acetylcholinesterase and
       some tissue proteases.
       In Vivo. 1993 Sep; 7(5): 431-434.
       PMID: 8110987; UI: 94154192.

     Giniatullin RA, et al.           [See Related Articles]
       A correlation between quantal content and decay time of endplate
currents in frog muscles with intact
       cholinesterase.
       J Physiol (Lond). 1993 Jul; 466: 95-103.
       PMID: 8410718; UI: 94015983.

     Farms WB, et al.           [See Related Articles]
       Effect of copper-deficient diet on metabolism in rat auditory
structures.
       Hear Res. 1993 May; 67(1-2): 45-50.
       PMID: 8101836; UI: 93339987.

     Besser R, et al.           [See Related Articles]
       Impaired neuromuscular transmission during partial inhibition of
acetylcholinesterase: the role of
       stimulus-induced antidromic backfiring in the generation of the
decrement-increment phenomenon.
       Muscle Nerve. 1992 Oct; 15(10): 1072-1080.
       PMID: 1328879; UI: 93024671.

     Giniatullin RA, et al.           [See Related Articles]
       [Non-quantal secretion of a mediator as factor determining
consequences of acetylcholinesterase inhibition].
       Biull Eksp Biol Med. 1992 Jul; 114(7): 6-7. Russian.
       PMID: 1421312; UI: 93043229.

     Hilf G, et al.           [See Related Articles]
       Agonist-independent inhibition of G protein activation by muscarinic
acetylcholine receptor antagonists in
       cardiac membranes.
       Eur J Pharmacol. 1992 Mar 12; 225(3): 245-252.
       PMID: 1516656; UI: 92387316.

     Khazipov RN, et al.           [See Related Articles]
       [Effect of magnesium ions on the functional state of postsynaptic
membrane by modulation of the level of
       non-quantal secretion of the mediator].
       Neirofiziologiia. 1992; 24(1): 97-100. Russian.
       PMID: 1584312; UI: 92261736.

     Giniatullin RA, et al.           [See Related Articles]
       [Effect of the quantal composition, membrane potential and
cholinoreceptor density on the temporal flow of the
       end plate current in the rat under conditions of
acetylcholinesterase inhibition].
       Neirofiziologiia. 1992; 24(3): 269-279. Russian.
       PMID: 1513401; UI: 92382672.

     Braga MF, et al.           [See Related Articles]
       Effects of tacrine, velnacrine (HP029), suronacrine (HP128), and
3,4-diaminopyridine on skeletal
       neuromuscular transmission in vitro.
       Br J Pharmacol. 1991 Apr; 102(4): 909-915.
       PMID: 1649660; UI: 91308896.

     Yang CM, et al.           [See Related Articles]
       Down-regulation of muscarinic receptors in the striatum of
organophosphate-treated swine.
       Toxicol Appl Pharmacol. 1990 Jul; 104(3): 375-385.
       PMID: 2385834; UI: 90350123.

     Hurlbut WP, et al.           [See Related Articles]
       Correlation between quantal secretion and vesicle loss at the frog
neuromuscular junction.
       J Physiol (Lond). 1990 Jun; 425: 501-526.
       PMID: 2120425; UI: 91012193.

     Perelman A, et al.           [See Related Articles]
       Differential association and distribution of acetyl- and
butyrylcholinesterases within rat liver subcellular
       organelles.
       J Biol Chem. 1990 Jan 5; 265(1): 214-220.
       PMID: 2152920; UI: 90094401.

     Szabolcs M.           [See Related Articles]
       Enzymatic properties, metal composition and SH-group reactivity of
fragmented sarcoplasmic reticulum
       isolated from rabbit skeletal muscle.
       Acta Biochim Biophys Hung. 1990; 25(1-2): 111-124.
       PMID: 1966646; UI: 92024654.

     Endres W, et al.           [See Related Articles]
       Acetylcholinesterase reactivators antagonize epileptiform bursting
induced by paraoxon in guinea pig
       hippocampal slices.
       J Pharmacol Exp Ther. 1989 Dec; 251(3): 1181-1186.
       PMID: 2600810; UI: 90095866.



Best of results,

Chuck






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