ITER Independent Database of Human Health Risk Values Expands

Chuck Miller rellim at MAILHOST.TCS.TULANE.EDU
Thu Oct 22 20:44:15 EST 1998


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ITER Independent Database of Human Health Risk Values Expands to Address
Critical Need

Toxicology Excellence for Risk Assessment (TERA) and Concurrent
Technologies Corporation (CTC) are pleased to announce the expansion of
the International Toxicity Estimates for Risk (ITER) database in
September 1998.  The database, found on the Internet at
http://www.tera.org/iter, is the only on-line source of compiled risk
values that provides side-by-side comparisons of risk values from
federal and international agencies, as well as those developed by
independent parties.  It provides access to the scientific justification
for each agency=92s values, and an explanation of how the values were
derived and for any differences among values from the different
sources.  TERA and CTC have worked to expand ITER because it supports
their respective missions to protect public health and develop leading
edge technologies.  The two organizations recognize a critical need for
risk assessors and environmental managers world-wide to have access to
the most current and reliable risk values available.

Risk assessors and managers may find it difficult to interpret and
compare risk values developed by different organizations, since each
organization develops risk values using its own methods and practices.
Risk values developed by some organizations may not be readily
available, because they are found only in lengthy documents not easily
obtained or available on the Internet.  Existing risk assessment values
need updating to incorporate new toxicologic and mechanistic data, and
to reflect more current risk assessment methods.  The ITER database and
related peer-review program address these issues by making values easily
accessible, facilitating side-by-side comparisons, and by providing a
venue for independent peer review of new assessments.

ITER was developed by TERA; a non-profit organization dedicated to the
best use of toxicity data for risk assessment, and has been expanded and
revised through a cooperative venture with CTC, another non-profit
organization which develops and transfers leading edge technologies to
help the U.S. be more competitive in the world market place.  A pilot
version with 39 chemicals has been available since early 1996.  With
this expansion, risk values for over 100 chemicals that are
environmental pollutants are included.  Easily accessible risk values
are also necessary for pollution prevention efforts, by facilitating the
identification of the least environmentally damaging chemical for a
given industrial process.  This expansion was funded through the
National Defense Center for Environmental Excellence (NDCEE) operated by
CTC.

ITER currently contains risk values from several agencies; including
ATSDR=92s minimal risk levels (MRLs), EPA=92s risk values from the
Integrated Risk Information System (IRIS), and Health Canada=92s risk
values for Priority Substances under the Canadian Environmental
Protection Act (CEPA).  Independently derived values, which have
undergone an independent peer review, are also included and can only be
found on ITER.  All of these values are presented in a tabular format
for ease of comparison and the reasons for differences among the
organizations=92 values are explained.  Independently derived values for
methylmercury and acrylonitrile are currently available and additional
values for Telone II (1,3-dichloropropene) and chromium VI will be
available shortly.  These independent values and their supporting
documentation have undergone a rigorous peer review through TERA=92s =
peer
review program which provides an independent, balanced and
scientifically-based peer review.  More information about the peer
review program is available at http://www.tera.org/peer.

Future plans for the database include adding values from additional
organizations, including the World Health Organization, the
International Programme on Chemical Safety, values from the Dutch RIVM,
and possibly others.  It is anticipated that all of EPA=92s IRIS values
(over 500 chemicals) will be on the ITER database by the end of 1998

For more information about the scientific aspects of the database or how
to become a partner in this effort, contact Jacqueline Patterson at
patterson at tera.org or (513) 521-7426, or Chuck Tomljanovic (CTC) at
chuck-t at ctc.com or (814) 269-6834.


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<DIV>ITER Independent Database of Human Health Risk Values Expands to=20
Address<BR>Critical Need<BR><BR>Toxicology Excellence for Risk =
Assessment (TERA)=20
and Concurrent<BR>Technologies Corporation (CTC) are pleased to announce =
the=20
expansion of<BR>the International Toxicity Estimates for Risk (ITER) =
database=20
in<BR>September 1998.&nbsp; The database, found on the Internet at<BR><A =

href=3D"http://www.tera.org/iter">http://www.tera.org/iter</A>, is the =
only=20
on-line source of compiled risk<BR>values that provides side-by-side =
comparisons=20
of risk values from<BR>federal and international agencies, as well as =
those=20
developed by<BR>independent parties.&nbsp; It provides access to the =
scientific=20
justification<BR>for each agency&rsquo;s values, and an explanation of =
how the=20
values were<BR>derived and for any differences among values from the=20
different<BR>sources.&nbsp; TERA and CTC have worked to expand ITER =
because it=20
supports<BR>their respective missions to protect public health and =
develop=20
leading<BR>edge technologies.&nbsp; The two organizations recognize a =
critical=20
need for<BR>risk assessors and environmental managers world-wide to have =
access=20
to<BR>the most current and reliable risk values available.<BR><BR>Risk =
assessors=20
and managers may find it difficult to interpret and<BR>compare risk =
values=20
developed by different organizations, since each<BR>organization =
develops risk=20
values using its own methods and practices.<BR>Risk values developed by =
some=20
organizations may not be readily<BR>available, because they are found =
only in=20
lengthy documents not easily<BR>obtained or available on the =
Internet.&nbsp;=20
Existing risk assessment values<BR>need updating to incorporate new =
toxicologic=20
and mechanistic data, and<BR>to reflect more current risk assessment=20
methods.&nbsp; The ITER database and<BR>related peer-review program =
address=20
these issues by making values easily<BR>accessible, facilitating =
side-by-side=20
comparisons, and by providing a<BR>venue for independent peer review of =
new=20
assessments.<BR><BR>ITER was developed by TERA; a non-profit =
organization=20
dedicated to the<BR>best use of toxicity data for risk assessment, and =
has been=20
expanded and<BR>revised through a cooperative venture with CTC, another=20
non-profit<BR>organization which develops and transfers leading edge=20
technologies to<BR>help the U.S. be more competitive in the world market =

place.&nbsp; A pilot<BR>version with 39 chemicals has been available =
since early=20
1996.&nbsp; With<BR>this expansion, risk values for over 100 chemicals =
that=20
are<BR>environmental pollutants are included.&nbsp; Easily accessible =
risk=20
values<BR>are also necessary for pollution prevention efforts, by =
facilitating=20
the<BR>identification of the least environmentally damaging chemical for =

a<BR>given industrial process.&nbsp; This expansion was funded through=20
the<BR>National Defense Center for Environmental Excellence (NDCEE) =
operated=20
by<BR>CTC.<BR><BR>ITER currently contains risk values from several =
agencies;=20
including<BR>ATSDR&rsquo;s minimal risk levels (MRLs), EPA&rsquo;s risk =
values=20
from the<BR>Integrated Risk Information System (IRIS), and Health =
Canada&rsquo;s=20
risk<BR>values for Priority Substances under the Canadian=20
Environmental<BR>Protection Act (CEPA).&nbsp; Independently derived =
values,=20
which have<BR>undergone an independent peer review, are also included =
and can=20
only be<BR>found on ITER.&nbsp; All of these values are presented in a =
tabular=20
format<BR>for ease of comparison and the reasons for differences among=20
the<BR>organizations&rsquo; values are explained.&nbsp; Independently =
derived=20
values for<BR>methylmercury and acrylonitrile are currently available =
and=20
additional<BR>values for Telone II (1,3-dichloropropene) and chromium VI =
will=20
be<BR>available shortly.&nbsp; These independent values and their=20
supporting<BR>documentation have undergone a rigorous peer review =
through=20
TERA&rsquo;s peer<BR>review program which provides an independent, =
balanced=20
and<BR>scientifically-based peer review.&nbsp; More information about =
the=20
peer<BR>review program is available at <A=20
href=3D"http://www.tera.org/peer">http://www.tera.org/peer</A>.<BR><BR>Fu=
ture=20
plans for the database include adding values from =
additional<BR>organizations,=20
including the World Health Organization, the<BR>International Programme =
on=20
Chemical Safety, values from the Dutch RIVM,<BR>and possibly =
others.&nbsp; It is=20
anticipated that all of EPA&rsquo;s IRIS values<BR>(over 500 chemicals) =
will be=20
on the ITER database by the end of 1998<BR><BR>For more information =
about the=20
scientific aspects of the database or how<BR>to become a partner in this =
effort,=20
contact Jacqueline Patterson at<BR><A=20
href=3D"mailto:patterson at tera.org">patterson at tera.org</A> or (513) =
521-7426, or=20
Chuck Tomljanovic (CTC) at<BR><A=20
href=3D"mailto:chuck-t at ctc.com">chuck-t at ctc.com</A> or (814)=20
269-6834.<BR></DIV></BODY></HTML>

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