inhibition of semen production by acyclovir long term use?

Chuck Miller rellim at MAILHOST.TCS.TULANE.EDU
Mon Nov 22 10:45:17 EST 1999


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m.wasicky at xpoint.at asked about the long term reproductive effects of the 
anti-viral acyclovir .
It does seem that there is a reason to be concerned about reproductive
effects of acyclovir, at least in the male.

Best,
Chuck

Hum Exp Toxicol 1997 Sep;16(9):505-11
Ganciclovir induces reproductive hazards in male rats after short-term
exposure.
Faqi AS, Klug A, Merker HJ, Chahoud I
Institut fur Klinische Pharmakologie und Toxikologie, Freie Universitat,
Berlin, Germany.
1. The effect of short-term treatment of ganciclovir on male reproduction in
adult rats was studied. The animals were treated subcutaneously with either
a single dose of 60 mg/kg daily for 5 days (Gan5day) or with 100 mg/kg
administered three times at 4 h-intervals (Gan1day). The effects were
investigated every 2 weeks up to 8 weeks, followed by investigations 16 and
24 weeks after treatment to detect the potential of recovery. 2. Time to
mating was significantly increased in Gan1day group. The pregnancy index and
outcome were only decreased 8 weeks (Gan5day and Gan1day) or 16 weeks
(Gan1day) after treatment. 3. The lowest values of sperm variables studied
were registered 8 weeks after treatment: The number of spermatid was reduced
up to 4% (Gan5day) or 2% (Gan1day) of control; the sperm number was 5% and
8% of control in Gan5day and Gan1day, respectively. Over 80% of sperm were
abnormal in Gan5day group, and only few normal sperm was detected in Gan1day
group. 4. Morphological investigation of testes revealed a clearcut
time-dependency effect. Four weeks after treatment distinct alterations were
located exclusively in the peripheral part of the tubuli which included fat
inclusions, cell and pyknotic nuclear debris and swellings of Sertoli cells.
The effect was reversible 24 weeks after treatment. 5. Ganciclovir induces
testicular damage and affects sperm variables after short-term exposure. The
intensity and degree of the hazards varied in between the time of
investigation after treatment. PMID: 9306137, UI: 97451161


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<HEAD>
<TITLE>Re: inhibition of semen production by acyclovir long term use?</TITL=
E>
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<FONT FACE=3D"Times">m.wasicky at xpoint.at asked about the long term reproducti=
ve effects of the anti-viral acyclovir .<BR>
It does seem that there is a reason to be concerned about reproductive effe=
cts of acyclovir, at least in the male.<BR>
<BR>
Best,<BR>
Chuck<BR>
<I><BR>
<B>Hum Exp Toxicol</B></I><B> 1997 Sep;16(9):505-11 <BR>
<FONT SIZE=3D"5">Ganciclovir induces reproductive hazards in male rats after =
short-term exposure.<BR>
</FONT>Faqi AS, Klug A, Merker HJ, Chahoud I<BR>
</B>Institut fur Klinische Pharmakologie und Toxikologie, Freie Universitat=
, Berlin, Germany. <BR>
1. The effect of short-term treatment of ganciclovir on male reproduction i=
n adult rats was studied. The animals were treated subcutaneously with eithe=
r a single dose of 60 mg/kg daily for 5 days (Gan5day) or with 100 mg/kg adm=
inistered three times at 4 h-intervals (Gan1day). The effects were investiga=
ted every 2 weeks up to 8 weeks, followed by investigations 16 and 24 weeks =
after treatment to detect the potential of recovery. 2. Time to mating was s=
ignificantly increased in Gan1day group. The pregnancy index and outcome wer=
e only decreased 8 weeks (Gan5day and Gan1day) or 16 weeks (Gan1day) after t=
reatment. 3. The lowest values of sperm variables studied were registered 8 =
weeks after treatment: The number of spermatid was reduced up to 4% (Gan5day=
) or 2% (Gan1day) of control; the sperm number was 5% and 8% of control in G=
an5day and Gan1day, respectively. Over 80% of sperm were abnormal in Gan5day=
 group, and only few normal sperm was detected in Gan1day group. 4. Morpholo=
gical investigation of testes revealed a clearcut time-dependency effect. Fo=
ur weeks after treatment distinct alterations were located exclusively in th=
e peripheral part of the tubuli which included fat inclusions, cell and pykn=
otic nuclear debris and swellings of Sertoli cells. The effect was reversibl=
e 24 weeks after treatment. 5. Ganciclovir induces testicular damage and aff=
ects sperm variables after short-term exposure. The intensity and degree of =
the hazards varied in between the time of investigation after treatment. PMI=
D: 9306137, UI: 97451161 <BR>
<BR>
</FONT>
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