Lidocaine metabolites immunoactive? (Was: Re: Local anesthetic a carcinogen (Was: Re: Amalgam study))

Brian Sandle bsandle at southern.co.nz
Wed Oct 27 00:40:31 EST 1999


In sci.med.dentistry Brian Sandle <bsandle at southern.co.nz> wrote:
: In sci.med.dentistry Brian Sandle <bsandle at southern.co.nz> wrote:
: : In sci.med.dentistry Brian Sandle <bsandle at southern.co.nz> wrote:: :   Carcinogenesis 1994 Oct;15(10):2287-90
: : : :   
: : : :2,6-Dimethylaniline--hemoglobin adducts from lidocaine in humans.
: : : : 
: : : :    Bryant MS, Simmons HF, Harrell RE, Hinson JA
: : [...]
: : : J Autoimmun 1995 Apr;8(2):293-303
: : :  
: : : Autoantibodies to cryptic epitopes of C-reactive protein and other acute
: : : phase proteins in the toxic oil syndrome.
: : :  
: : : Bell SA, Du Clos TW, Khursigara G, Picazo JJ, Rubin RL
: : :  
: : : Toxic oil syndrome (TOS) was caused by the consumption of rapeseed oil
: : : contaminated with derivatives of aniline. Many persons who survived the
: : : acute phase developed a puzzling, multi-year chronic disease considered to
: : : be inflammatory or autoimmune in nature.
: : [...]
: : Lidocaine can be immediately a problem for some people. An allergic 
: : reaction occurs. But could there be a longer term problem caused by 
: : aniline metabolites of lidocaine?

: Now does Lidocaine cross into to embryonic or fetal blood?

: Do lidocaine metabolites pass over?

: Does the embryo or fetus have the same risk of allergenicity or aniline 
: toxicity as the mother?

: What is more dangerous, amalgam or aniline?

Now quite a few people have their amalgam fillings removed and replaced 
with composite. Not all of them get any better. Also a number of people 
report feeling unwell after a dental visit.

I wonder if the aniline metabolites from the anaesthetic has been a problem 
for a lot. Besides composite trouble, that is.



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