Lidocaine, immunotoxicity, and chronic diseases?
bsandle at SOUTHERN.CO.NZ
Thu Oct 28 00:06:03 EST 1999
On Wed, 27 Oct 1999, c. miller wrote:
> Date: Wed, 27 Oct 1999 09:41:45 -0600
> From: c. miller <rellim at mailhost.tcs.tulane.edu>
> To: toxicol at net.bio.net, bsandle at kalessin.southern.co.nz
> Subject: Lidocaine, immunotoxicity, and chronic diseases?
> Brian Sandle posed some interesting questions about lidocaine metabolism,
> dimethylaniline, immunoreactivity, and chronic disease(s) below.
> I was wondering about the titers of aniline-albumin, aniline-hemoglobin (or
> other protein) antibodies following lidocaine anesthesia. Are they
> detectable? Is there an anti-idiotypic response as well?
> Aniline is a reasonably good hapten. Perhaps following lidocaine treatment
> (and its metabolism) as the primary immune challenge, it seems possible
> that aniline (or related compounds) exposure could be common enough of an
> environmental factor to perpetuate some level of chronic immune response
> (at least in some people).
Searching the databases for various combinations of
cognitive affective prenatal perinatal birth anesthetic epidural
shows some adverse effects in infancy of prenatal or perinatal
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