Does weight loss cause mobilization of toxicants from fat ?

c. miller rellim at MAILHOST.TCS.TULANE.EDU
Thu Sep 2 13:52:03 EST 1999


Hi Ann and others,

I looked in Ch. 5 of Casarett & Doull and found Rozman and Klassen's
discussion of fat as a storage depot. In this chapter they state (or
predict) that obese persons will be protected from lipophilic toxicants
(due to their greater fat reservior), and talk about sudden increases of
lipophilic toxicants into the blood compartment--but there are no
references cited in this section. They state that starvation in animals
that were previously exposed to organochlorine insecticides induced signs
of intoxication, but it is not clear whether this result was due to the
rapid liberation of insecticide from the fat compartment or due to the
effects of starvation on a compromised nervous system. Has anyone actually
measured a significant increase of a lipophilic toxicant in blood or
another compartment following a period of dieting (fat loss)? I have found
the example of increased blood lead (Pb) concentrations following a round
of chelation with EDTA. This is  presumably due to the mobilization of Pb
from the bone pool. Does such a thing happen with lipophilic agents (carbon
tetrachloride, hexachlorobenzene, DDT, TCDD) upon weight loss? Some people
have suggested that irractic behavior observed in some dieters is due to
the rapid liberation of lipophilic toxicants (-or could it simply be due to
low sugar levels in the CNS?).  Is there any basis for this notion of
diet-induced intoxication by lipophilic compounds?


Best,

Chuck


Dr. Charles A. Miller III,   rellim at mailhost.tcs.tulane.edu
Dept. Environmental Health Sciences, SL29
Tulane-Xavier Center for Bioenvironmental Research and
Tulane Univ. School of Public Health and Tropical Medicine
1430 Tulane Ave.
New Orleans, LA 70112
(504)585-6942, fax (504)584-1726
Bionet.toxicology newsgroup: http://www.bio.net/hypermail/TOXICOLOGY





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