In a toxicity study (MTD), we administered a new drug to BALB/c mice 3 doses
(1g, 2g, 3g) aged between 608 weeks.We observed with the high dosage (3g):
* diminition of blood glucose level
* diminition of alkaline phosphatase
* diminition of Blood urea nitrogen (BUN)
* Bilirubin = 0 mg/dl
* élevation of GOT and GPT
* Splenomegaly
Can we conclude that our drug is toxic at that dose for the liver and kidney
and spleen.
Your comments are highly appreciated
Thanks
Abdel
