FW: DNA Repair Interest Group -UPDATE - April 6, 2001

Charles Miller rellim at tulane.edu
Fri Apr 6 12:02:32 EST 2001


----------
From: "Kenneth H. Kraemer" <khk at nih.gov>
Reply-To: Ken Kraemer <kraemerk at nih.gov>
Date: Fri, 6 Apr 2001 11:56:33 -0400
To: DNAREPAIR-L at LIST.NIH.GOV
Subject: DNA Repair Interest Group -UPDATE - April 6, 2001

1.      VIDEOCONFERENCE - TUES, APR 17, 2001 - 12:30 PM- Dr. Arthur
Grollman -  Recognition of Oxidative damage by DNA Glycosylases

2.      ANNOUNCEMENTS: HUMAN DNA REPAIR GENES LOCATED IN THE HUMAN GENOME
AND LISTED ON THE WEB; HUMAN DIVERSITY-ORIENTED DNA REPOSITORY, TEL AVIV
UNIVERSITY

3.      CONFERENCES - PHOTOPROTECTION CONFERENCE;  MIDWEST DNA REPAIR
MEETING; AMERICAN SOCIETY FOR PHOTOBIOLOGY;  FASEB HELICASE MEETING; YEAST
AS A MODEL FOR MITOCHONDRIA-RELATED HUMAN DISORDERS; EUROPEAN SOCIETY FOR
PHOTOBIOLOGY

4.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Baltimore, MD;
        Rockville, MD; Cell; Rochester, NY; Stony Brook, NY; Burlington,
VT; Boston, MA; Bethesda, MD; Smithville, TX

5.      Electronic Contacts



1.0     DNA REPAIR VIDEOCONFERENCE:

TUES, APR 17, 2001 - 12:30 PM- Dr. Arthur Grollman -SUNY Stony Brook, NY -
Recognition of Oxidative damage by DNA Glycosylases

VIDEOCONFERENCE LOCATIONS:  State University of New York, Stony Brook, NY
(ORIGIN); Room 1E03 GRC Baltimore, MD; MD Anderson, Smithville, TX; Univ
of Kentucky, Lexington, KY; Building 45 (NATCHER) Room H, Bethesda, MD ;
Building 101 Room B200, NIEHS, Research Triangle Park,  NC ; Building 549,
Conference Room A,  FCRDC, Frederick, MD; Lawrence Livermore Labs,
Livermore, CA ; Univ of Michigan, Ann Arbor; and Brookhaven National Labs,
Upton, NY. MBONE ACCESS (NIH ONLY) and in the internet at
http://videocast.nih.gov

1.1     DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE
[Note: A larger and more up to date list of future and past
videoconferences can be found on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

1.1.1 FUTURE VIDEOCONFERENCES:

Tues, May 15, 2001- Dr. Bill Copeland - Laboratory of Molecular Genetics
NIEHS - Mitochondrial DNA Replication Fidelity and Mitochondrial Diseases

Tues, June 19, 2001 - Dr. James Cleaver -Univ of California, San
Francisco, CA - History of DNA Repair - Mending Human Genes

1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE):

Now 36 of these videoconferences have been archived and are available for
viewing at your leisure on the internet. You will need a web browser (with
a high speed link) and free Real Video software.  Setup details and access
are available at the NIH videocast website:  http://videocast.nih.gov. Go
to Unicast sessions; Past events; DNA Repair Interest Group Sessions.

Note: Technical improvements are made regularly on this site to increase
transmission speeds and ease of access. If you were not successful in
viewing these videos in the past it is worth trying again!

MAR 20, 2001 - Short talks at 3 sites:
Peter Beernink, LLNL - A Second Divalent Metal Ion in the Active Site of a
New Crystal Form of Human Apurinic/Apyridinimic Endonuclease, Ape1, and
its Implications for the Catalytic Mechanism

Yong Hwan Jin, NIEHS - The 3'-5' Exonuclease of DNA Polymerase d is
Redundant with
5'-flap Endonuclease Rad27/Fen1 for Processing of Okazaki Fragments

Robert M. Brosh, NIA - Molecular Interactions of the Werner Syndrome
Protein

FEB 20, 2001 - Dr. Vilhelm Bohr - LMG, NIA, Baltimore, MD -  DNA repair
defects in premature aging disorders

JAN 16, 2001- Dr. Mats Ljungman - Univ of Michigan, Ann Arbor, MI -Stopped
in its tracks - RNA polymerase II as a sensor for DNA damage

DEC 19, 2000 - Dr. Patrick Sung - University of Texas Health Science
Center at San Antonio - Functional Interactions Among RAD52 Group Proteins
in Recombination and Repair

NOV 21, 2000 -Dr. Zhigang Wang - Univ of Kentucky -Translesion synthesis
by the UmuC family of DNA polymerase

OCT 17, 2000- Dr. Yoshihiro Matsumoto - Fox Chase Cancer Center,
Philadelphia, PA -Functions of PCNA in Base Excision Repair

SEPT 19, 2000 - Dr. Kenneth Kraemer, NCI, Bethesda, MD  -Clinical and
Molecular Features of Xeroderma Pigmentosum and Related Disorders of DNA
Repair

JUNE 20, 2000- Dr. Richard Setlow , Brookhaven National Lab- Reflections
on how I was led into and onto DNA Repair -  Host:  SUNY

MAY 16, 2000  Dr. Veronica Maher, Michigan State Univ - Role of DNA
Replication and Repair in Carcinogen-Induced Human Cell Mutagenesis  Host:
U of Michigan [Note: this talk will be posted after the data presented is
published]

APR 18, 2000 - Dr. Peter Glazer, Yale Univ - Targeted genome modification
via DNA triple helix formation

MAR 21, 2000 - Research reports by 3 Postdoctoral fellows:
Dr. Steffen Emmert, NCI - The xeroderma pigmentosum group C gene leads to
selective repair of cyclobutane pyrimidine dimers rather than 6-4
photoproducts. [See recent paper describing this work: Proc. Natl. Acad.
Sci. USA 97: 2151-2156, 2000]

Dr. Robert Sobol, NIEHS - Mutagenesis and dRP Lyase Activity in DNA
-Polymerase Dependent Base Excision Repair in Mouse Cells [See recent
paper by Dr. Sobol describing this work:  Nature 405, 807-810 (2000)]

Mr. Robert Levine, SUNY -Mutagenesis Induced by Endogenous DNA Adducts in
Human Cells

FEB 15, 2000  Dr Steve Matson, UNC - Two E. coli mismatch repair enzymes,
DNA helicase II and MutL, interact to catalyze efficient unwinding of
duplex DNA

JAN 18, 2000- Dr. John Essigman, MIT - Cellular responses to the DNA
damaging agent cisplatin

Through the miracle of vidotape we now have been able to post most of the
DNA Repair Interest Group videoconferences from 1998 and 1999 on the web
site.  These include talks by Drs. Bogenhagen, Sutherland, Kunkel,
Stefanini, Hanawalt, Matson, Sharan, Kashlev , Fornace, Anderson, Leadon,
Brooks, McKay, Drotschmann, Chu, Thompson, Woodgate, George, Liu and
Grossman

2.      ANNOUNCEMENTS: HUMAN DNA REPAIR GENES LOCATED IN THE HUMAN GENOME
AND LISTED ON THE WEB; HUMAN DIVERSITY-ORIENTED DNA REPOSITORY, TEL AVIV
UNIVERSITY

2.1 Dr. Rick Wood writes:

For your next DNA repair interest group update, it may be useful to note
the compilation of more than 100 human DNA repair genes in the Feb. 16,
2001 issue of Science (291, pp. 1284-1289). This article can be accessed
online.
http://www.sciencemag.org/cgi/content/abstract/291/5507/1284

An online Table with links to Gene Cards and NCBI gives ready access to a
huge amount of information on 127 DNA repair genes and their protein
products. The most recent version of the table is available at:
http://www.cgal.icnet.uk/DNA_Repair_Genes.html
Dr. Wood welcomes suggestions for additions and corrections.

Contact Dr. Wood at r.wood at icrf.icnet.uk

2.2 HUMAN DIVERSITY-ORIENTED DNA REPOSITORY, TEL AVIV UNIVERSITY
Dear Dr Kraemer,

I hope that you and your colleagues will be interested in our human
diversity-oriented DNA repository, a unique resource for the study of
human DNA polymorphism.

The National Laboratory for the Genetics of Israeli Populations at
Tel-Aviv University has a unique DNA collection representing the large
ethnic variation of Israeli populations. We have in our repository nearly
2000 DNA samples and cell lines from healthy unrelated individuals. Our
sample donors include unrelated representatives of European, Asian,
African and Middle-Eastern communities. We already distributed over 6500
DNA samples to reserchers in the USA, Canada, Europe, Australia, Japan,
India and Israel.

Individuals who donated blood samples for the preparation of the human
cell lines and the DNA collection have signed written consent for the
study of their genome for pure and applied research purposes. The coded
DNA samples are kept with strict confidentiality; only sex and ethnic
background are supplied along with the DNA samples.

For more information kindly visit our web site:
http://www.tau.ac.il/medicine/NLGIP/nlgip.htm

Details on prices and sample availability are at:
http://www.tau.ac.il/medicine/NLGIP/catalog.htm
I shall be happy to answer specific questions on sample availability.

Sincerely,

David Gurwitz, Ph.D.
National Laboratory for the Genetics of Israeli Populations
Room 306
Sackler Faculty of Medicine
Tel-Aviv University
Tel-Aviv 69978, ISRAEL

voice/fax: +972-3-640-7611
e-mail:
gurwitz at post.tau.ac.ilhttp://www.tau.ac.il/medicine/NLGIP/nlgip.htm


3.    CONFERENCES - PHOTOPROTECTION CONFERENCE;  MIDWEST DNA REPAIR
MEETING; AMERICAN SOCIETY FOR PHOTOBIOLOGY;  FASEB HELICASE MEETING; YEAST
AS A MODEL FOR MITOCHONDRIA-RELATED HUMAN DISORDERS; EUROPEAN SOCIETY FOR
PHOTOBIOLOGY

[Note: A larger and more up-to-date list of conferences can be found on
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

3.1  PHOTOPROTECTION CONFERENCE - KRAKOV, POLAND, MAY 19-22, 2001

The conference on PHOTOPROTECTION (skin and eyes and related topics such
as commercial sunscreens and melanins) I am organizing with Prof Tad Sarna
at the Jagiellonian University, Krakov, Poland from 19-22 May .

Please note that should you wish accommodation in an en suite University
room it is quite cheap and good quality but we have only 30 such rooms so
it is first come
first served!

Of course, there will be a social programme that will probably include a
welcome reception in the old part of the University, an Italian lunch in a
nearby cafe, a conference dinner and a guided tour of Krakov. As an option
there may be a possibility of a visit to the nearby and famous salt
mine!

If you need any more information please e-mail me at  cha31 at keele.ac.uk

Yours sincerely

George Truscott
Keele University, UK



3.2     THIRD ANNUAL MIDWEST DNA REPAIR SYMPOSIUM: JUNE 2-3, 2001 INDIANA
UNIVERSITY SCHOOL OF MEDICINE, INDIANAPOLIS, IN
        Keynote speakers: Dr. Samuel H. Wilson, NIEHS, Dr. Stanton L.
Gerson, Case Western Reserve Univ.

        More details are on the website:
http://www.iupui.edu/~wellsctr/sympage.htm
        Contact information:
        Drs Mark Kelley and David A. Williams
        TEL: 317-274-2755;      FAX; 317-274-5378;
        e-mail:  mkelley at iupui.edu

3.3   2001 ANNUAL MEETING OF THE AMERICAN SOCIETY FOR PHOTOBIOLOGY:JULY
7-12, CHICAGO

It is my pleasure to invite you to the 2001 Annual Meeting of the American
Society for Photobiology, which will be held at the downtown Chicago
Marriott Hotel on July 7-12. The meeting has been organized taking into
account the interests and needs of all ASP members. A unique variety of
invited lectures, symposia, and award presentations will be important
parts of our meeting. The real success of each ASP meeting, however, is
largely related to the attendance and participation by our membership.
Platform and poster presentations, which provide new information on a wide
range of photobiology topics of interest to our members, will be an
integral part of the 2001 ASP meeting.

For the convenience of our members, we will be using on-line abstract
submission and registration for the Chicago meeting. Please note that the
deadline for receipt of abstracts has been extended to March 15. Student
travel awards will again be offered and I invite all members to encourage
their students and trainees to apply for a 2001 ASP travel award.
Informational material for the meeting has been sent to all members.
Additional information on the 2001 ASP meeting can be found at the
Photobiology Website: www.POL-US.net. I look forward to seeing all of you
in Chicago in July!

Charles J. Gomer
Scientific Program Chairman

3.4     HELICASES: STRUCTURE, FUNCTION AND ROLES IN HUMAN DISEASE  -JULY
7-12, 2001  VERMONT ACADEMY,  SAXTONS RIVER VERMONT

A FASEB helicase meeting to be held July 7-12, 2001 at the Vermont
Academy, Saxtons River Vermont.

Session subtopics include:
Helicase Structure
Helicase Function and Mechanism
Helicases in DNA Replication
Helicases in DNA Repair and Recombination
RNA Helicases in Transcription, Splicing, RNA stability and transport
RNA Helicases in Translation and  Ribosome Biogenesis
Helicases as part of macromolecular machines
Helicases in Viral Replication
Helicases in Cancer and Aging.

This will be the first meeting held in the United States dedicated
entirely to helicases.   Further information can be obtained from meeting
organizers:  Sandy Weller, University of Connecticut HealthCenter,
weller at nso2.uchc.edu, 860-679-2310 and Steve Matson, Univeristy of North
Carolina smatson at bio.unc.edu, 919-962-0005.  Vice-chairs will be Anna
Marie Pyle (amp11 at columbia.edu) and Smita Patel (patelss at umdnj.edu).
Please pass on to colleagues who may be interested.


3.5 YEAST AS A MODEL FOR MITOCHONDRIA-RELATED HUMAN DISORDERS -AUGUST
25-26, 2001 - PRAGUE, CZECH REPUBLIC

In Honor of Piotr P. Slonimski and his seminal work in mitochondrial
genetics

August 25-26, 2001
Prague, Czech Republic

To be held shortly before the opening of the "XXth International
Conference on Yeast Genetics and Molecular Biology (ICYGMB)".

Organizing Committee:
J. Houtek (Prague), J. Kolarov (Bratislava), Robert Naviaux (San Diego)
and Keshav Singh (Baltimore)

All necessary information and further details about the symposium will be
included soon on the web site of the XXth ICYGMB
(http://www.biomed.cas.cz/yeast2001/). The organizers kindly ask those who
are interested to participate in the symposium to follow the web site and
to spread this information to all potential participants.

Abstracts and registration should be submitted via the e-mail address
mito at biomed.cas.cz
to:
****************************************************************************
**
MITO 2001 Secretariat
Institute of Physiology
Academy of Sciences of the Czech Republic
Videnska 1083, 142 20 Prague 4
Czech Republic
****************************************************************************
**

For questions and remarks contact:

kolarov at fns.uniba.sk
Jordan Kolarov
Department of Biochemistry, Faculty of Sciences, Comenius University Ml.
Dolina CH-I,
SK-842 15 Bratislava Slovakia
Phone: +421-7-602 96 539 Fax: +421-7-602 96 452

houstek at biomed.cas.cz
Josef Houstek Department of Bioenergetics, Institute of Physiology,
Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Praha 4,
Czech Republic,
Phone: +420-2-475 2434 Fax: +420-2-475 2149

3.6   9TH CONGRESS OF THE EUROPEAN SOCIETY FOR PHOTOBIOLOGY - SEPTEMBER
3-8, 2001, LILLEHAMMER, NORWAY

The 9th Congress of the European Society for Photobiology will be arranged
in Lillehammer, Norway, 3 - 8 September 2001. It is a pleasure to welcome
you to the Congress and to invite you to submit an abstract. The Congress
home page where the Second Announcement and Call for Abstracts can be
found, has the address  http://esp.nrpa.no , and information can also be
found on www.pol-us.net or www.pol-europe.net.

You may also obtain additional information and a paper copy of the Second
Announcement by writing to the Congress Secretariat: P.O.Box 55, NO-1332
Osteras,
Norway.

I'm looking forward to seeing you in Lillehammer.

Best regards

Terje Christensen
(Chairman of the Local Organising Committee)


4.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Baltimore, MD;
Rockville, MD; Cell; Rochester, NY; Stony Brook, NY; Burlington, VT;
Boston, MA; Bethesda, MD; Smithville, TX
[Note: Check the list for more Job Opportunities on the DNA Repair
Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ ]


4.1 TENURE TRACK INVESTIGATOR NATIONAL INSTITUTE ON AGING - BALTIMORE

The Intramural Research Program of the National Institute on Aging,
Baltimore, Maryland, is recruiting a tenure track investigator for the
Laboratory of Molecular Genetics (LMG).  The individual is expected to
develop an independent research program with a basis in DNA repair and an
interest in immunology and aging.

Candidates with extensive experience in the molecular biochemistry of DNA
repair in mammalian models are encouraged to apply.  Applicants must have
a strong record of scientific accomplishments including publication
record, excellence in laboratory research, a history of independent
research accomplishments and a reputation in their research area.

Current research in the Laboratory is focused on DNA repair in human
premature aging syndromes, oxidative DNA damage, processing helicase
functions and gene targeting.

Applicants should send a curriculum vitae, three letters of reference, and
a statement of research interests to:

Chair, LMG Tenure Track Search Committee,
c/o Pat Boyce, HR Staff Office,
National Institute on Aging, NIH,
Box 26,
5600 Nathan Shock Dr.,
Baltimore, MD 21224-6825.

Attn:  VA# NIA- 01-004.

For further information E-mail Dr. V. Bohr, Chief, LMG at vbohr at nih.gov.

Applications must be postmarked by  April 19, 2000.  NIH is an Equal
Opportunity Employer.

4.2  CLINICAL RESEARCH ASSISTANT - UV EFFECTS ON THE SKIN - FDA, ROCKVILLE
MD

Organization:  U.S. Food and Drug Administration
                  Center for Devices and Radiological Health
                  Rockville, MD 20850

Background information: We are expanding our existing research program of
ultraviolet (UV) clinical studies (entitled "Quantitative, Biologically
Relevant Parameters for Testing and Standardization of Skin Response to
UV"). The additional work will include tasks which will attempt to
optimize UV tanning schedules for human skin.  The studies utilize a wide
range of physical and biological methods.  The scientific information
generated supports public health policies aimed at reduction of the risk
from the use of UV-emitting and -transmitting products.

Job Description:

A team member is needed to join our study group in human studies on
UV-induced tanning (training may be provided where necessary).

Duties include but are not limited to:

        Coordinating the enrollment and scheduling of human subjects
        Operating non-invasive instruments to measure the skin's response
to UV radiation
        Operating radiometric equipment to measure the amount of UV
radiation incident on the skin
        Performing initial processing of skin biopsies
        Providing data analysis (including the use of Excel)
        Performing literature searches and preparation of summaries
        Participating in preparations of presentations and manuscripts for
publication (PowerPoint experience desirable)

Ability to communicate both orally and in writing, to work effectively in
a team environment and with the clinical study subjects is essential.

This position is currently available for up to two years.
U.S. citizenship preferred.

Starting date: Summer/Fall 2001

Educational Requirements:

Minimum Bachelors Degree in Physical or Life Sciences, preferably with at
least 2 yrs experience in human studies or other research-related clinical
setting. Candidates with higher degrees are welcome.  Experience in the
use of optical instrumentation or with dermatology issues would be a plus.

Contact:

Sharon Miller (HFZ-134)
Food and Drug Administration
Center for Devices and Radiological Health
Office of Science and Technology
Division of Physical Sciences
Electro-optics Branch
301-827-4692
e-mail: sym at cdrh.fda.gov



4.3     SENIOR SCIENTIFIC EDITOR AT CELL AND MOLECULAR CELL

Cell Press has been expanding its editorial team over the past year. We
have recruited a group of very talented scientists with interests in
diverse areas of biology. We are currently seeking someone with expertise
in DNA metabolism (replication, recombination or repair) for the position
of senior scientific editor at Cell and Molecular Cell. The ideal
candidate will have a Ph.D. (some postdoctoral experience is preferred,
although we would consider a talented Ph.D. student close to graduation),
broad interests in biomedical research and the ability to think critically
about a wide range of issues. Primary responsibilities will include the
editorial assessment of manuscripts for Cell and Molecular Cell,
commissioning review material for Molecular Cell, and representing both
journals at scientific meetings.

As you may have heard, in July we are launching a sister journal to
Molecular Cell that will focus on cell and developmental biology, and will
be called Developmental Cell. We view this as a unique opportunity to
redefine the scope and mission of Molecular Cell, and the successful
candidate will be heavily involved in this process.

If you know anyone who might be interested in this opportunity to pursue a
career in scientific publishing, I would greatly appreciate it if you
would ask them to please send their C.V., and a letter describing their
qualifications and research interests to Vivian Siegel at vsiegel at cell.com
or by mail to:

Vivian Siegel
Editor
Cell/Molecular Cell
1100 Massachusetts Ave
Cambridge MA 02138 USA


4.4  POSTDOCTORAL FELLOWSHIPS AVAILABLE FOR RESEARCH ON DNA DAMAGE
TOLERANCE MECHANISMS IN EUKARYOTES AND E.COLI, ROCHESTER NY.

Two postdoctoral positions are immediately available (each presently
funded for 3-4 years) to investigate the mechanisms of damage tolerance in
eukaryotes and E. coli, with emphasis on translesion replication and
mutagenesis.

One position is for work on yeast and human DNA polymerase zeta, Rev1p,
and associated proteins (see Nelson et al., Science 272: 1646, 1996;
Nelson et al., Nature 382: 729, 1996; Gibbs et al., Proc Natl Acad Sci USA
95: 6876, 1998; Gibbs et al., Proc Natl Acad Sci USA 97: 4186, 2000), and
also on other damage tolerance mechanisms in yeast.

The other is for work on translesion replication in E. coli (see
Vanderwiele et al., Proc Natl Acad Sci USA 95: 15519, 1998; O'Grady et al.
J Bact 182: 2285), and recombination-dependent damage tolerance processes.

Rochester is an affordable high-tech community located in beautiful
upstate New York, and the Medical School together with the adjacent
undergraduate campus contains a large group of faculty working in the life
sciences.

For more information, call or email to the address below. To apply, please
send your C.V., a description of your research experience, and the names,
addresses, telephone numbers and email addresses of three references, to:
Christopher Lawrence, Department of Biochemistry and Biophysics,
University of Rochester Medical Center, Rochester NY 14642, USA. Tel:
(716) 275-2948; Fax: (716) 275-6007; email:
christopher_lawrence at urmc.rochester.edu

4.5 POSTDOCTORAL POSITION AT SUNY  - STONY BROOK, NY

A position is available for in vitro and in vivo research probing the
cellular mechanisms for processing DNA adducts, including DNA repair,
mutagenesis and recombination. We use human cells and human cell extracts
for these studies. Applicants should have good experience in general
molecular biology techniques, protein expression and purification, and
anti-sense technology.

Contact:
Masaaki Moriya, PhD
Department of Pharmacological Sciences
State University of New York at Stony Brook, NY 11794-8651
E-mail: maki at pharm.sunysb.edu
Send resume and names of three references.


4.6      POSTDOCTORAL POSITIONS AVAILABLE AT THE UNIVERSITY OF VERMONT
1. To use X-ray crystallographic approaches to study the interactions
between DNA lesions and DNA polymerases and DNA repair glycosylases-two
positions with four years of funding available

2. To use cell biological and biochemical approaches to determine the role
that base excision repair plays in the processing of radiation damage and
its consequences in mammalian cells - two positions with multiple year
funding available

Successful applicants would part of an interactive multidisciplinary group
studying oxidative DNA damage processing using a variety of approaches.
The Department and University environments are collegial and supportive.
There is a strong postdoctoral and graduate student community here and
Burlington is an easy and fun place to live. Prior postdoctoral fellows
have been very successful in obtaining academic and/or industrial
positions.

Interested applicants should send CV and names of three references to:
Dr. Susan Wallace
Department of Microbiology and Molecular Genetics
University of Vermont
Burlington, Vt. 05405

swallace at zoo.uvm.edu
802-656-2164



4.7      POSTDOCTORAL OPPORTUNITIES IN RADIATION BIOLOGY/DNA REPAIR AT THE
HARVARD SCHOOL OF PUBLIC HEALTH

Web site: http://www.hsph.harvard.edu/ccb/rb/

This program is supported by the National Cancer Institute to provide
research training in modern Radiation Biology.  The program covers a broad
array of subjects conducted in internationally recognized laboratories:

 cell biology of radiation effects
 cellular responses to free radicals and stress
 checkpoint activation and cellular responses to DNA damage
 DNA repair and radiation mutagenesis
 mechanisms of apoptosis activation
 molecular epidemiology
 development of novel radiotherapy agents

The training program is based in Department of Cancer Cell Biology of the
Harvard School of Public Health, but preceptors are also located at the
Medical School, representing the Division of Nuclear Medicine and the
Department Radiation Oncology, and at the Dana-Farber Cancer Center, the
Brigham and Women's Hospital, the Beth Israel-Deaconess Medical Center,
and the Massachusetts General Hospital.

A major strength of this program is the diversity of its faculty and the
opportunity for fellows to interact with world-class scientists and
physicians in the Harvard biomedical research complex.  In addition, the
Harvard School of Public Health and Harvard Medical School provide a
unique environment with state-of-the-art core facilities for cellular and
molecular analysis, data processing, and outstanding libraries and other
support services.  The Boston area is an excellent location for young
scientists, with top colleagues in all disciplines and visiting lecturers
from around the world.

Applicants must have a PhD in biology, biophysics, or related sciences, or
an MD, DVM, or other suitable degree.  Applicants must be citizens or
permanent residents of the United States.  The training program consists
of 2-3 years of laboratory research and training under one of the
preceptors, including opportunities to present research accomplishments at
local, national, and international meetings.  Past trainees have obtained
leadership positions in academic, government and industrial research.

Please contact a preceptor directly or send a curriculum vitae and the
names and addresses of three references to:

Professor Bruce Demple, Director
Radiation Biology Training Program
Department of Cancer Cell Biology
Harvard School of Public Health
665 Huntington Avenue
Boston, MA  02115

E-mail: bdemple at hsph.harvard.edu


4.8 NIH POSTDOCTORAL POSITIONS AVAILABLE

Postdoctoral Positions (3) are available with the Nuclear Medicine
Department, National Institutes of Health, Bethesda, MD to study the
molecular and cellular effects of ionizing radiation. Current research
interests include DNA repair mechanisms, particularly DNA double-strand
break repair, structural analysis of radiation induced DNA damage, and
methods for production of positioned radiation damage in nucleic acids.

Candidates should possess a recent Ph.D., M.D., or equivalent degree (5 or
fewer years postgraduate). Experience in molecular biology, biochemistry,
or nucleic acid chemistry is a plus. Please send a CV with the names and
contact information for 3 references, along with a brief description of
your research experience to:

Dr. Thomas A. Winters
Bldg. 10, Room 1C401
10 Center Drive
Bethesda, MD, 20892-1180
email: twinters at mail.nih.gov
Fax: 301-480-9712


4.9    POSTDOCTORAL POSITION- UNIVERSITY OF TEXAS M.D. ANDERSON CANCER
CENTER, SCIENCE PARK-RESEARCH DIVISION, DEPARTMENT OF CARCINOGENESIS
A position is available for a doctoral scientist with U.S. citizenship
with interest and experience in the study of DNA damage and mutation.  The
project is funded by the Life in Extreme Environments program at NSF and
will involve studies on the relationship between DNA degradation and
speciation in glacial bacteria.  Experience with Comet assay, bacterial
genetics, or mismatch repair would be helpful.  If interested please
contact (by phone or email):

David L. Mitchell, Ph.D.
Associate Professor Department of Carcinogenesis
The University of Texas M.D. Anderson Cancer Center
Science Park/Research Division
P.O. Box 389 Smithville, TX 78957
Phone: (512) 237-9474 Email: dmitch at io.com



5.      ELECTRONIC CONTACTS:
5.1     Check out the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
You can find the schedule for future DNA Repair Interest Group
videoconferences and a listing of past videoconferences (with links to the
videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair
and MEETING NOTICES.

5.2     Encourage your colleagues who are interested in DNA Repair to
request that they be added to this DNA Repair Interest Group listserve
e-mail list by sending a request by e-mail to: listserv at list.nih.gov
Leave the subject  blank. In the message field, type in: subscribe
DNARepair-L your name
        Alternatively, by filling out the form on the website you can both
add your name to the e-mail list and have your name posted on the website.
If you want your name to be listed you can fill out the "Join the SIG"
form on the web site and add your name to the listing of members.  If you
are not at NIH then be sure to click the "other" box and then fill in the
name of your institution.

5.3     Archives of these listserve mailings can be found at
        http://list.nih.gov/archives/dnarepair-l.html
                or via links from the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/

5.4     I will be happy to relay information about post-doctoral
positions, jobs and meetings and other information related to DNA Repair.
Please send me an e-mail message (kraemerk at nih.gov) and I will incorporate
it into the next announcement list and post it on the DNA Repair Interest
Group web site: http://www.nih.gov:80/sigs/dna-rep/ .
(This list goes to more than 700 scientists around the world who are
interested in DNA repair.)


Kenneth H. Kraemer, M.D.
Basic Research Laboratory
National Cancer Institute
Building 37 Room 3E24
Bethesda,  MD 20892
301-496-9033    FAX: 301-496-8419
e-mail: kraemerk at nih.gov
DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/


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