FW: DNA Repair Interest Group -UPDATE - August 1, 2001

Charles Miller rellim at tulane.edu
Wed Aug 1 15:29:57 EST 2001


----------
From: "Kenneth H. Kraemer" <khk at nih.gov>
Reply-To: Ken Kraemer <kraemerk at nih.gov>
Date: Wed, 1 Aug 2001 14:14:43 -0400
To: DNAREPAIR-L at LIST.NIH.GOV
Subject: DNA Repair Interest Group -UPDATE - August 1, 2001

DNA Repair Interest Group -UPDATE - August 1, 2001

1.      VIDEOCONFERENCE - SUMMER VACATION - TALKS TO RESUME SEPT 11, 2001-
Dr. Fumio Hanaoka

2. ANNOUNCEMENTS: (NIH only) NIH Research Festival, October 2-5, Natcher
Conference Center - Poster Submission Available Online-Deadline August 6
- DNA Repair Symposium October 4.

3.      CONFERENCES - YEAST AS A MODEL FOR MITOCHONDRIA-RELATED HUMAN
DISORDERS; EUROPEAN SOCIETY FOR PHOTOBIOLOGY; ESPCR (European Society for
Pigment Cell Research); FUNCTIONAL GENOMICS CONFERENCE

4.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Baltimore, MD; Livermore,
CA; Baltimore, MD; Berkeley, CA; Boston, MA; Madison, WI; Rockville, MD;
Rochester, NY; Stony Brook, NY

5.      Electronic Contacts



1.0     DNA REPAIR VIDEOCONFERENCE:

THE CONFERENCES ARE TAKING A SUMMER VACATION AND WILL RESUME SEPT 11, 2001

Sept 11, 2001 - Tues 12:30PM - Dr. Fumio Hanaoka - Osaka University,
Osaka, Japan - Functional roles of XPC and XPV proteins: different
molecular defects in patients with similar clinical features

VIDEOCONFERENCE LOCATIONS:  Building 45 (NATCHER) Room H, Bethesda, MD
(origin);  Building 101 Room B200, NIEHS, Research Triangle Park, NC;
State University of New York, Stony Brook, NY; Room 1E03 GRC Baltimore,
MD; MD Anderson, Smithville, TX; Univ of Kentucky, Lexington, KY; Building
549, Conference Room A,  FCRDC, Frederick, MD; Lawrence Livermore Labs,
Livermore, CA; Univ of Michigan, Ann Arbor; Brookhaven National Labs,
Upton, NY and University of Pittsburgh and live on the internet at
http://videocast.nih.gov

1.1     DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE
[Note: A larger and more up to date list of future and past
videoconferences can be found on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

1.1.1 FUTURE VIDEOCONFERENCES:
We will be taking a summer break, videoconferences will resume in Sept.
Here is the new schedule:

Oct 16, 2001 - Tues 12:30PM - Dr. Daniel Yarosh - Applied Genetics -
Reduction of Skin Cancer in XP Patients Treated Topically with DNA Repair
Enzymes

Nov 13, 2001 - Tues 12:30PM - Dr. Christopher States - University of
Louisville- Cisplatin regulation of XPA expression in ovarian cancer cells

Dec 18, 2001 - Tues 12:30PM - Dr. Richard Wood - Univ of Pittsburgh-
Tolerating damaged DNA

Jan 15, 2002 - Tues 12:30PM - Dr. Tom Kunkel- NIEHS - Recent studies of
DNA Mismatch Repair

Feb 19, 2002 - Tues 12:30PM - TBA

Mar 19, 2002 - Tues 12:30PM - TBA

Apr 16, 2002 - Tues 12:30PM - Dr. Philip Hanawalt - History of DNA Repair

May 21, 2002 - Tues 12:30PM - TBA

June 18, 2002 - Tues 12:30PM - TBA



1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE):
Now 36 of these videoconferences have been archived and are available for
viewing at your leisure on the internet. You will need a web browser (with
a high speed link) and free Real Video software.  Setup details and access
are available at the NIH videocast website:  http://videocast.nih.gov. Go
to Unicast sessions; Past events; DNA Repair Interest Group Sessions.

Note: Technical improvements are made regularly on this site to increase
transmission speeds and ease of access. If you were not successful in
viewing these videos in the past it is worth trying again!

JUNE 19, 2001 - Dr. James Cleaver -Univ of California, San Francisco, CA -
History of DNA Repair - Mending Human Genes

MAY 15, 2001- Dr. Bill Copeland - Laboratory of Molecular Genetics NIEHS -
Family A DNA polymerases in eukaryotic DNA replication and repair
Note: Posting of this videoconference will be delayed for a few months at
the request of the speaker.

MAR 20, 2001 - Short talks at 3 sites:
Peter Beernink, LLNL - A Second Divalent Metal Ion in the Active Site of a
New Crystal Form of Human Apurinic/Apyridinimic Endonuclease, Ape1, and
its Implications for the Catalytic Mechanism

Yong Hwan Jin, NIEHS - The 3'-5' Exonuclease of DNA Polymerase d is
Redundant with
5'-flap Endonuclease Rad27/Fen1 for Processing of Okazaki Fragments

Robert M. Brosh, NIA - Molecular Interactions of the Werner Syndrome
Protein

FEB 20, 2001 - Dr. Vilhelm Bohr - LMG, NIA, Baltimore, MD -  DNA repair
defects in premature aging disorders

JAN 16, 2001- Dr. Mats Ljungman - Univ of Michigan, Ann Arbor, MI -Stopped
in its tracks - RNA polymerase II as a sensor for DNA damage

DEC 19, 2000 - Dr. Patrick Sung - University of Texas Health Science
Center at San Antonio - Functional Interactions Among RAD52 Group Proteins
in Recombination and Repair

NOV 21, 2000 -Dr. Zhigang Wang - Univ of Kentucky -Translesion synthesis
by the UmuC family of DNA polymerase

OCT 17, 2000- Dr. Yoshihiro Matsumoto - Fox Chase Cancer Center,
Philadelphia, PA -Functions of PCNA in Base Excision Repair

SEPT 19, 2000 - Dr. Kenneth Kraemer, NCI, Bethesda, MD  -Clinical and
Molecular Features of Xeroderma Pigmentosum and Related Disorders of DNA
Repair

JUNE 20, 2000- Dr. Richard Setlow , Brookhaven National Lab- Reflections
on how I was led into and onto DNA Repair -  Host:  SUNY

MAY 16, 2000  Dr. Veronica Maher, Michigan State Univ - Role of DNA
Replication and Repair in Carcinogen-Induced Human Cell Mutagenesis  Host:
U of Michigan [Note: this talk will be posted after the data presented is
published]

APR 18, 2000 - Dr. Peter Glazer, Yale Univ - Targeted genome modification
via DNA triple helix formation

MAR 21, 2000 - Research reports by 3 Postdoctoral fellows:
Dr. Steffen Emmert, NCI - The xeroderma pigmentosum group C gene leads to
selective repair of cyclobutane pyrimidine dimers rather than 6-4
photoproducts. [See recent paper describing this work: Proc. Natl. Acad.
Sci. USA 97: 2151-2156, 2000]

Dr. Robert Sobol, NIEHS - Mutagenesis and dRP Lyase Activity in DNA
-Polymerase Dependent Base Excision Repair in Mouse Cells [See recent
paper by Dr. Sobol describing this work:  Nature 405, 807-810 (2000)]

Mr. Robert Levine, SUNY -Mutagenesis Induced by Endogenous DNA Adducts in
Human Cells

FEB 15, 2000  Dr Steve Matson, UNC - Two E. coli mismatch repair enzymes,
DNA helicase II and MutL, interact to catalyze efficient unwinding of
duplex DNA

JAN 18, 2000- Dr. John Essigman, MIT - Cellular responses to the DNA
damaging agent cisplatin

Through the miracle of vidotape we now have been able to post most of the
DNA Repair Interest Group videoconferences from 1998 and 1999 on the web
site.  These include talks by Drs. Bogenhagen, Sutherland, Kunkel,
Stefanini, Hanawalt, Matson, Sharan, Kashlev , Fornace, Anderson, Leadon,
Brooks, McKay, Drotschmann, Chu, Thompson, Woodgate, George, Liu and
Grossman

2.      ANNOUNCEMENTS: (NIH only) NIH Research Festival, October 2-5,
Natcher Conference Center Poster Submission Available Online-Deadline
August 6
        http://festival01.nih.gov -  DNA Repair Symposium October 4.

The 15th annual NIH Research Festival, the yearly showcase for the NIH
intramural research program, will be held October 2-5. The Research
Festival Organizing Committee, co-chaired by Dr. Peter Lipsky, NIAMS, and
Dr. J. Carl Barrett, NCI, is now accepting submission of poster abstracts
by all NIH staff and FDA/CBER staff from the Bethesda campus. Posters in
any area of research conducted at NIH will be considered for presentation
but the committee is requesting a limit of one poster submission per
presenter. The deadline for online poster submission is 5:00 p.m., Monday,
August 6. Applicants will receive e-mail confirmation of receipt of poster
abstracts and will be notified of acceptance by e-mail in mid-August.

        There will be a DNA Repair Symposium on October 4. Speakers: Drs.
Roger Woodgate, Wei Yang, Vilhelm Bohr, and Ken Kraemer

For a preliminary general schedule of events and the online poster
registration form, visit the Research Festival Web site at
http://festival01.nih.gov .

For more information about poster registration or the NIH Research
Festival, contact Paula Cohen, OD/OCPL, at 6-1776 or e-mail:
pc68v at nih.gov.


3.    CONFERENCES - YEAST AS A MODEL FOR MITOCHONDRIA-RELATED HUMAN
DISORDERS; EUROPEAN SOCIETY FOR PHOTOBIOLOGY; ESPCR (European Society for
Pigment Cell Research); FUNCTIONAL GENOMICS CONFERENCE

[Note: A larger and more up-to-date list of conferences can be found on
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

3.1 YEAST AS A MODEL FOR MITOCHONDRIA-RELATED HUMAN DISORDERS -AUGUST
25-26, 2001 - PRAGUE, CZECH REPUBLIC

In Honor of Piotr P. Slonimski and his seminal work in mitochondrial
genetics

August 25-26, 2001
Prague, Czech Republic

To be held shortly before the opening of the "XXth International
Conference on Yeast Genetics and Molecular Biology (ICYGMB)".

Organizing Committee:
J. Houtek (Prague), J. Kolarov (Bratislava), Robert Naviaux (San Diego)
and Keshav Singh (Baltimore)

All necessary information and further details about the symposium will be
included soon on the web site of the XXth ICYGMB
(http://www.biomed.cas.cz/yeast2001/). The organizers kindly ask those who
are interested to participate in the symposium to follow the web site and
to spread this information to all potential participants.

Abstracts and registration should be submitted via the e-mail address
mito at biomed.cas.cz
to:
****************************************************************************
**
MITO 2001 Secretariat
Institute of Physiology
Academy of Sciences of the Czech Republic
Videnska 1083, 142 20 Prague 4
Czech Republic
****************************************************************************
**

For questions and remarks contact:

kolarov at fns.uniba.sk
Jordan Kolarov
Department of Biochemistry, Faculty of Sciences, Comenius University Ml.
Dolina CH-I,
SK-842 15 Bratislava Slovakia
Phone: +421-7-602 96 539 Fax: +421-7-602 96 452

houstek at biomed.cas.cz
Josef Houstek Department of Bioenergetics, Institute of Physiology,
Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Praha 4,
Czech Republic,
Phone: +420-2-475 2434 Fax: +420-2-475 2149

3.2   9TH CONGRESS OF THE EUROPEAN SOCIETY FOR PHOTOBIOLOGY - SEPTEMBER
3-8, 2001, LILLEHAMMER, NORWAY

The 9th Congress of the European Society for Photobiology will be arranged
in Lillehammer, Norway, 3 - 8 September 2001. It is a pleasure to welcome
you to the Congress and to invite you to submit an abstract. The Congress
home page where the Second Announcement and Call for Abstracts can be
found, has the address  http://esp.nrpa.no , and information can also be
found on www.pol-us.net or www.pol-europe.net.

You may also obtain additional information and a paper copy of the Second
Announcement by writing to the Congress Secretariat: P.O.Box 55, NO-1332
Osteras,
Norway.

I'm looking forward to seeing you in Lillehammer.

Best regards

Terje Christensen
(Chairman of the Local Organising Committee)

3.3  ESPCR (European Society for Pigment Cell Research)- 10th meeting.
ROME, 26-29 September, 2001

Dear friend,

In case you haven't already made arrangements for the coming ESPCR
meeting, this is to remind you that there is still time to register for
this attractive conference at the lower rate, before the early
registration deadline of July 30. We recommend hurrying though, as it will
become increasingly difficult to obtain hotel accommodation. Please
encourage your colleagues to do the same, especially younger scientists,
who can get special registration rates, learn a lot, and
make valuable contacts!

LATE ABSTRACTS - The deadline for submission of abstracts for publication
and for oral talks is now past, but you can still send in a poster
abstract if you wish, for inclusion in the Late Abstracts listing, which
will be distributed at the meeting. You can either use
the form you were sent, or download a copy from our Web page, or just
format the text as described and send it in by e-mail to the address onthe
form.

**** Late Abstract Deadline: Friday August 24th ****
Or just come along and relax as a spectator, or join in the discussions.
We have a terrific program in store. There are numerous first-rate
speakers (Ortonne, Taieb, Prota, Goding, Sturm, Ballabio, Pavan, Dupin,
MacNeil, Sarna, Hu, Seabra, Ito, Westerhof, Cascinelli, Lejeune and many
others, plus free communications), in a wide range of
session topics from the clinical to ground-breaking basic research. If you
don't have the Second Announcement to hand, you can check the program any
time at the web site-

http://www.ulb.ac.be/medecine/loce/espcr/rome.htm

And of course, please leave yourself some time to visit Rome - enjoy the
historic buildings, museums and unrivalled restaurants, in the pleasantly
warm weather that September is likely to offer. Don't miss it!
Registration Fee by September 3rd: 180 EURO (ESPCR MEMBER); 220 EURO (NON
ESPCR MEMBER); 120 EURO (YOUNG RESEARCH, including resident fellows and
researchers under 35 years of age)
after September 3rd, and On-site: 220, 250, and 150 EURO in the order.
For any information, please contact:
espcr2001 at triumphpr.it
Ph. +39 06 399631
fax +39 0639963244

Looking forward to seeing you there,
Dr. Mauro Picardo
Scientific Director
San Gallicano - Dermatological Institute
Via San Gallicano 25/A
I00153 Rome, Italy
Tel. +39 (0) 58543 651
Fax +39 (0) 58543 740

3.4 FUNCTIONAL GENOMICS SATELLITE CONFERENCE, SEATTLE, WA  - OCT 16-18,
2001The US-EMS and IAEMS invite you to attend the Functional Genomics
Satellite Conference.  Key scientists and thought leaders will discuss
areas as diverse as identifying disease-genome connections, expression
analysis, sequencing and annotation, SNP analysis, comparative genomics,
proteomics and new technologies.  A keynote talk and reception starts the
meeting on Tuesday evening.  Spotfire and Omniviz will host lunchtime
demonstrations of their new technologies for genomic analysis.  An evening
cruise on Puget Sound offers traditional Northwest cuisine, spectacular
scenery and time for socializing with new and old friends.  See
www.genomicfunctions.org for agenda and registration details



4.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Baltimore, MD; Livermore,
CA; Baltimore, MD; Berkeley, CA; Boston, MA; Madison, WI; Rockville, MD;
Rochester, NY; Stony Brook, NY [Note: Check the list for more Job
Opportunities on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

4.1  POST DOCTORAL POSITION -NIA, BALTIMORE, MD
A postdoctoral position for a recent Ph.D. (less than 5 yr of experience)
is available to study DNA helicases defective in premature aging and
cancer syndromes. The goal is to understand the roles of human helicases
in pathways of genome stability. The focus of the work is to understand
how protein and DNA interactions of DNA helicases are important to the
biological roles of these enzymes in DNA metabolism. The postdoctoral
fellow will work in a collaborative group of scientists who have interests
in DNA replication/repair and the emerging field of molecular gerontology.

For more information, please contact:
Robert M. Brosh, Jr., Ph.D.
Laboratory of Molecular Gerontology
National Institute on Aging, NIH
email:  broshr at grc.nia.nih.gov



4.2 POST-DOCTORAL POSITION - DNA REPAIR GROUP -LAWRENCE LIVERMORE NATIONAL
LABORATORY, CA

The major apurinic/apyrimidinic (AP) endonuclease/3 -repair diesterase in
mammals is Ape1. This enzyme initiates repair of abasic lesions and DNA
strand breaks harboring 3 -oxidative damages (e.g. 3 -phosphates and 3
-phosphoglycolates) by incising immediately 5  to the AP site or by
excising 3 -blocking groups directly. Other proteins of BER act in concert
to complete the repair process and preserve genome integrity. Ape1 also
regulates (through an independent "Ref-1" function) the DNA binding
activities of several transcriptional regulators, most notably p53, AP-1
and NF-kB, and in this capacity, may operate as a key factor in cellular
oxidation/reduction (redox) stress responses.

The open post-doctoral position entails defining the contributions of
Ape1's nuclease and redox functions to specific cellular attributes by
overexpressing selectively-inactivating mutant proteins and by creating a
null cell line. Experience in mammalian cell culture/biology is essential.

Please send CV and three letters of recommendation to:

David M. Wilson III, Ph.D.
Biology and Biotechnology Research Program, L-441
Lawrence Livermore National Laboratory
7000 East Avenue
Livermore, CA 94551
email: wilson61 at llnl.gov
TEL: (925) 423 0695

Position to start this fall. LLNL is an interactive research laboratory
located in the hills of the San Francisco bay area, approximately 45 miles
from the city's downtown.



4.3 TENURE TRACK INVESTIGATOR NATIONAL INSTITUTE ON AGING - BALTIMORE

The Intramural Research Program of the National Institute on Aging,
Baltimore, Maryland, is recruiting a tenure track investigator for the
Laboratory of Molecular Gerontology (LMG).  The individual is expected to
develop an independent research program with a basis in DNA repair and
related processes.  Applicants must have a strong record of scientific
accomplishments including publication record, excellence in laboratory
research, and independent research.  Current research in the Laboratory is
focused on DNA repair in human premature aging syndromes, somatic
hypermutation, oxidative DNA damage processing, helicase functions and
gene targeting.  Applicants should send a curriculum vitae, three letters
of reference, and a statement of research interests to:  Chair, LMG Tenure
Track Search Committee, c/o Pat Boyce, HR Staff Office, National Institute
on Aging, NIH, Box 26, 5600 Nathan Shock Dr., Baltimore, MD 21224-6825.
Attn:  VA#NIA- 01-004.  For further information E-mail Dr. V. Bohr, Chief,
LMG at vbohr at nih.gov.

Applications must be postmarked by July 23, 2001.  NIH is an Equal
Opportunity Employer.



4.4 DNA DOUBLE-STRAND BREAK REPAIR: BIOCHEMISTRY AND CELL BIOLOGY -
BERKELEY, CA

Immediate opening for postdoctoral research positions in the laboratory of
Dr. David J. Chen at the Life Sciences Division, Lawrence Berkeley
National Laboratory.  The successful candidates will participate in an
interdisciplinary research program investigating protein biochemistry,
structure function analysis, and cell biology of the DNA double-strand
break repair (DSB) pathways in mammalian cells. We are interested in the
following research areas:

1 . Mechanisms of DNA nonhomologous end joining (NHEJ) pathway.
Characterization of DNA repair complex involved in NHEJ, reconstitution of
DNA end rejoining in vitro, understanding the role of DNA dependent
protein kinase activity in DSB repair and DNA damage sensing, functional
identifying its relevant phosphorylation substrates and radiation-induced
phosphorylation sites.

2. Functions of Homologous Recombination in DSB repair.  Research to
determine the roles of human Rad51 homologs in DNA dsb repair, delineating
the potential functional relationship between homologous recombination and
DNA nonhomologous end joining in radiation-induced dsb repair, effect of
HR in genome instability.

3. Function of DSB repair proteins at the telomere.  Mechanistic studies
on DNA repair proteins that participate in telomere maintenance,
functional analysis of the interaction between telomere binding proteins
and DNA repair protein complex.

Candidates with training in molecular or cell biology and experience in
protein biochemistry, gene expression, DNA homologous recombination
assays, DNA end joining assays, protein-protein interaction, telomere
metabolism and maintenance, or are encouraged to apply.   For application
send letter stating interests with c.v. and names of three references to:

Dr. David J. Chen,
Life Sciences Division, Building 74,
Lawrence Berkeley National Laboratory,
1 Cyclotron Road,  Berkeley, CA 94720,
E-Mail: djchen at lanl.gov, FAX: 510-486-6816

4.5 POSTDOCTORAL POSITIONS AT HARVARD MEDICAL SCHOOL AND
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - BOSTON, MA

Two postdoctoral positions are available immediately for an experienced
protein biochemist and a structural biologist who will join a team of
scientists characterizing how DNA base excision repair enzymes interact
with each other and with their DNA substrates. These functional and
physical interactions are being explored by genetic, biochemical, and
biophysical methods. The ultimate goal of these studies will be to capture
these interacting molecules for structural determination by x-ray
crystallography.

Applicants should send their curriculum vitae listing 3 references to:

Prof.Leona Samson (lsamson at mit.edu),
Division of Bioengineering and EnvironmentalHealth,
Massachusetts Institute of Technology,
77 Massachusetts Avenue,16-743B,
Cambridge MA 02139

or to Prof. Tom Ellenberger (tome at hms.harvard.edu),
Dept. Biological Chemistry and MolecularPharmacology,
Harvard Medical School,
240 Longwood Ave.,
Boston MA 02115.

4.6 POSTDOCTORAL POSITION - DEPARTMENT OF PHARMACEUTICAL SCIENCES
UNIVERSITY OF WISCONSIN-MADISON

A postdoctoral position is available immediately for research in
photochemistry and photobiology. The project involves the development of
new photosensitizers for photodynamic therapy and other biomedical
applications. The ideal candidate should hold a Ph.D. in Chemistry or
closely related area, and be prepared to work in a multidisciplinary
environment. Individuals with previous experience in one or more of the
following topics are particularly encouraged to apply: basic methods of
organic synthesis, NMR, HPLC, column chromatography, electronic and
fluorescence spectroscopy, nanosecond laser flash photolysis and cell
culture maintenance. Candidates should send a CV and the names of two
references to:

Prof. Guilherme L. Indig
School of Pharmacy
University of Wisconsin
Madison, WI 53706-1515

Phone: (608) 265-6664
Fax: (608) 262-3397
glindig at facstaff.wisc.edu
http://www.pharmacy.wisc.edu/facstaff/sciences/Indig.html



4.7  CLINICAL RESEARCH ASSISTANT - UV EFFECTS ON THE SKIN - FDA, ROCKVILLE
MD

Organization:  U.S. Food and Drug Administration
                  Center for Devices and Radiological Health
                  Rockville, MD 20850

Background information: We are expanding our existing research program of
ultraviolet (UV) clinical studies (entitled "Quantitative, Biologically
Relevant Parameters for Testing and Standardization of Skin Response to
UV"). The additional work will include tasks which will attempt to
optimize UV tanning schedules for human skin.  The studies utilize a wide
range of physical and biological methods.  The scientific information
generated supports public health policies aimed at reduction of the risk
from the use of UV-emitting and -transmitting products.

Job Description:

A team member is needed to join our study group in human studies on
UV-induced tanning (training may be provided where necessary).

Duties include but are not limited to:

        Coordinating the enrollment and scheduling of human subjects
        Operating non-invasive instruments to measure the skin's response
to UV radiation
        Operating radiometric equipment to measure the amount of UV
radiation incident on the skin
        Performing initial processing of skin biopsies
        Providing data analysis (including the use of Excel)
        Performing literature searches and preparation of summaries
        Participating in preparations of presentations and manuscripts for
publication (PowerPoint experience desirable)

Ability to communicate both orally and in writing, to work effectively in
a team environment and with the clinical study subjects is essential.

This position is currently available for up to two years.
U.S. citizenship preferred.

Starting date: Summer/Fall 2001

Educational Requirements:

Minimum Bachelors Degree in Physical or Life Sciences, preferably with at
least 2 yrs experience in human studies or other research-related clinical
setting. Candidates with higher degrees are welcome.  Experience in the
use of optical instrumentation or with dermatology issues would be a plus.

Contact:

Sharon Miller (HFZ-134)
Food and Drug Administration
Center for Devices and Radiological Health
Office of Science and Technology
Division of Physical Sciences
Electro-optics Branch
301-827-4692
e-mail: sym at cdrh.fda.gov

4.8       POSTDOCTORAL FELLOWSHIPS AVAILABLE FOR RESEARCH ON DNA DAMAGE
TOLERANCE MECHANISMS IN EUKARYOTES AND E.COLI, ROCHESTER NY.

Two postdoctoral positions are immediately available (each presently
funded for 3-4 years) to investigate the mechanisms of damage tolerance in
eukaryotes and E. coli, with emphasis on translesion replication and
mutagenesis.

One position is for work on yeast and human DNA polymerase zeta, Rev1p,
and associated proteins (see Nelson et al., Science 272: 1646, 1996;
Nelson et al., Nature 382: 729, 1996; Gibbs et al., Proc Natl Acad Sci USA
95: 6876, 1998; Gibbs et al., Proc Natl Acad Sci USA 97: 4186, 2000), and
also on other damage tolerance mechanisms in yeast.

The other is for work on translesion replication in E. coli (see
Vanderwiele et al., Proc Natl Acad Sci USA 95: 15519, 1998; O'Grady et al.
J Bact 182: 2285), and recombination-dependent damage tolerance processes.

Rochester is an affordable high-tech community located in beautiful
upstate New York, and the Medical School together with the adjacent
undergraduate campus contains a large group of faculty working in the life
sciences.

For more information, call or email to the address below. To apply, please
send your C.V., a description of your research experience, and the names,
addresses, telephone numbers and email addresses of three references, to:
Christopher Lawrence, Department of Biochemistry and Biophysics,
University of Rochester Medical Center, Rochester NY 14642, USA. Tel:
(716) 275-2948; Fax: (716) 275-6007; email:
christopher_lawrence at urmc.rochester.edu

4.9 POSTDOCTORAL POSITION AT SUNY  - STONY BROOK, NY

A position is available for in vitro and in vivo research probing the
cellular mechanisms for processing DNA adducts, including DNA repair,
mutagenesis and recombination. We use human cells and human cell extracts
for these studies. Applicants should have good experience in general
molecular biology techniques, protein expression and purification, and
anti-sense technology.

Contact:
Masaaki Moriya, PhD
Department of Pharmacological Sciences
State University of New York at Stony Brook, NY 11794-8651
E-mail: maki at pharm.sunysb.edu
Send resume and names of three references.


5.      ELECTRONIC CONTACTS:
5.1     Check out the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
You can find the schedule for future DNA Repair Interest Group
videoconferences and a listing of past videoconferences (with links to the
videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair
and MEETING NOTICES.

5.2     Encourage your colleagues who are interested in DNA Repair to
request that they be added to this DNA Repair Interest Group listserve
e-mail list by sending a request by e-mail to: listserv at list.nih.gov
Leave the subject  blank. In the message field, type in: subscribe
DNARepair-L your name
        Alternatively, by filling out the form on the website you can both
add your name to the e-mail list and have your name posted on the website.
If you want your name to be listed you can fill out the "Join the SIG"
form on the web site and add your name to the listing of members.  If you
are not at NIH then be sure to click the "other" box and then fill in the
name of your institution.

5.3     Archives of these listserve mailings can be found at
        http://list.nih.gov/archives/dnarepair-l.html
                or via links from the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/

5.4     I will be happy to relay information about post-doctoral
positions, jobs and meetings and other information related to DNA Repair.
Please send me an e-mail message (kraemerk at nih.gov) and I will incorporate
it into the next announcement list and post it on the DNA Repair Interest
Group web site: http://www.nih.gov:80/sigs/dna-rep/ .
(This list goes to nearly 750 scientists around the world who are
interested in DNA repair.)



Kenneth H. Kraemer, M.D.
Basic Research Laboratory
National Cancer Institute
Building 37 Room 3E24
Bethesda,  MD 20892
301-496-9033    FAX: 301-496-8419
e-mail: kraemerk at nih.gov
DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/


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