FW: NIH Public Genome Info Access - as you need it.

Charles Miller rellim at tulane.edu
Thu Aug 2 16:03:26 EST 2001


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From: "McClure.Michael" <mcclure at niehs.nih.gov>
Date: Mon, 23 Jul 2001 19:37:58 -0400
To: androlog/postmaster <androlog at uic.edu>, EmbryoMail
<Embryo-L at ANRI.barc.usda.gov>, RSANET <rsanet at list.nih.gov>, "Soc. for the
Study of Reproduction" <ssr at ns1.inxpress.net>, spermail/postmaster
<cummins at possum.murdoch.edu.au>
Cc: "McClure.Michael" <mcclure at niehs.nih.gov>
Subject: NIH Public Genome Info Access - as you need it.

>From Mike McClure/ NIH/NIEHS

Dear Colleagues: Please be aware that the results of the public genome
analysis effort, including human and mouse genomic sequence, cDNA
sequences, ESTs, SNPs, genetic maps, and clone-based physical maps,
are freely and
readily available to all scientists.  A compendium of many relevant
URLs can be found at The Genome Hub
http://www.nhgri.nih.gov/genome_hub.html

A great deal of annotated information has been laid onto the draft
human sequence through several major genome-wide annotation efforts,
including those at NCBI
http://www.ncbi.nlm.nih.gov/genome/guide/human/

Ensembl
http://www.ensembl.org <http://www.ensembl.org

and UC Santa Cruz
http://genome.cse.ucsc.edu

These assembled views of the human sequence are generally a preferable
place to look, rather
than the original unassembled accessions in the HTGS division of
GenBank. All data are available for downloading and all users may
search the data on
a genome-wide or chromosome-specific basis to find genes, SNPs, mouse
genome matches, and other features.  The sequence annotations also
include information about proteins and protein families.  Information
available in
the free public databases includes sequence, map, protein, expression,
and variation data.

The most recent large data set that has been added to the public
databases is three-fold whole genome shotgun coverage of the mouse
genome, including the electrophoretic traces.  The mouse data can be
searched by gene, contig, or clone identifier and users can BLAST
search the mouse with peptide predictions, cDNAs, and genomic DNA.
Access to the mouse data can be
obtained through NCBI
http://www.ncbi.nlm.nih.gov/genome/guide/M_musculus.html

and ensemble
http://mouse.ensembl.org


Michael E. McClure, Ph.D.
Chief, Organs and Systems Toxicology Branch
Tele: 919-541-5327
Division of Extramural Research and Training
Fax: 919-541-5064
National Institute of Environmental Health Sciences, NIH
E-Mail:  mm461n at nih.gov
111 T.W. Alexander Drive
Courier: 79 T.W. Alexander Dr
P.O. Box 12233, Mail Drop EC-23
Bldg. 4401, Rm. 3417
Research Triangle Park, North Carolina 27709
RTP. NC 27709



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