FW: DNA Repair Interest Group -UPDATE - March 17, 2001

Charles Miller rellim at tulane.edu
Sun Mar 18 10:58:26 EST 2001


----------
From: "Kenneth H. Kraemer" <khk at nih.gov>
Reply-To: Ken Kraemer <kraemerk at nih.gov>
Date: Sat, 17 Mar 2001 13:28:48 -0500
To: DNAREPAIR-L at LIST.NIH.GOV
Subject: DNA Repair Interest Group -UPDATE - March 17, 2001

DNA Repair Interest Group -UPDATE - March 17, 2001
HAPPY ST PATRICK'S DAY!

1.      VIDEOCONFERENCE - TUES, MAR 20, 2001 - 12:30 PM Short talks at 3
sites
        Peter Beernink, LLNL - Ape1 endonuclease; Yong Hwan Jin, NIEHS -
polymerase delta; Robert M. Brosh, NIA - Werner syndrome protein

2.      NIH SEMINAR - THURSDAY, MARCH 22 - 12:30 PM Genomic Integrity and
Double-Strand Break Repair in Mammals

3.      ANNOUNCEMENTS: HUMAN DNA REPAIR GENES LOCATED IN THE HUMAN GENOME
AND LISTED ON THE WEB

4.      CONFERENCES - PHOTOPROTECTION CONFERENCE;  MIDWEST DNA REPAIR
MEETING; AMERICAN SOCIETY FOR PHOTOBIOLOGY;  FASEB HELICASE MEETING; YEAST
AS A MODEL FOR MITOCHONDRIA-RELATED HUMAN DISORDERS; EUROPEAN SOCIETY FOR
PHOTOBIOLOGY

5.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Boston, MA; Bethesda, MD;
Smithville, TX; Indianapolis, IN; San Francisco, CA; Brookhaven National
Labs; Gaithersburg, MD; Bethesda, MD; Smithville, TX; Bethesda, MD

6.      Electronic Contacts



1.0     DNA REPAIR VIDEOCONFERENCE:

Tues, Mar 20, 2001 - 12:30 PM Short talks at 3 sites:

Peter Beernink, LLNL - A Second Divalent Metal Ion in the Active Site of a
New Crystal Form of Human Apurinic/Apyridinimic Endonuclease, Ape1, and
its Implications for the Catalytic Mechanism

Yong Hwan Jin, NIEHS - The 3'-5' Exonuclease of DNA Polymerase d is
Redundant with
5'-flap Endonuclease Rad27/Fen1 for Processing of Okazaki Fragments

Robert M. Brosh, NIA - Molecular Interactions of the Werner Syndrome
Protein

VIDEOCONFERENCE LOCATIONS:  Room 1E03 GRC Baltimore, MD (ORIGIN); MD
Anderson, Smithville, TX; Univ of Kentucky, Lexington, KY; Building 45
(NATCHER) Room H, Bethesda, MD ; Building 101 Room B200, NIEHS, Research
Triangle Park,  NC (ORIGIN); Building 549, Conference Room A,  FCRDC,
Frederick, MD; State University of New York, Stony Brook, NY; Lawrence
Livermore Labs, Livermore, CA (ORIGIN); Univ of Michigan, Ann Arbor; and
Brookhaven National Labs, Upton, NY. MBONE ACCESS (NIH ONLY) and in the
internet at http://videocast.nih.gov

1.1     DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE
[Note: A larger and more up to date list of future and past
videoconferences can be found on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

1.1.1 FUTURE VIDEOCONFERENCES:


Tues, Apr 17, 2001 - Dr. Arthur Grollman -SUNY Stony Brook, NY -
Recognition of Oxidative damage by DNA Glycosylases

Tues, May 15, 2001- Dr. Bill Copeland - Laboratory of Molecular Genetics
NIEHS - Mitochondrial DNA Replication Fidelity and Mitochondrial Diseases

Tues, June 19, 2001 - Dr. James Cleaver -Univ of California, San
Francisco, CA - History of DNA Repair - Mending Human Genes

1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE):

Now 33 of these videoconferences have been archived and are available for
viewing at your leisure on the internet. You will need a web browser (with
a high speed link) and free Real Video software.  Setup details and access
are available at the NIH videocast website:  http://videocast.nih.gov. Go
to Unicast sessions; Past events; DNA Repair Interest Group Sessions.

Note: Technical improvements are made regularly on this site to increase
transmission speeds and ease of access. If you were not successful in
viewing these videos in the past it is worth trying again!

FEB 20, 2001 - Dr. Vilhelm Bohr - LMG, NIA, Baltimore, MD -  DNA repair
defects in premature aging disorders

JAN 16, 2001- Dr. Mats Ljungman - Univ of Michigan, Ann Arbor, MI -Stopped
in its tracks - RNA polymerase II as a sensor for DNA damage

DEC 19, 2000 - Dr. Patrick Sung - University of Texas Health Science
Center at San Antonio - Functional Interactions Among RAD52 Group Proteins
in Recombination and Repair

NOV 21, 2000 -Dr. Zhigang Wang - Univ of Kentucky -Translesion synthesis
by the UmuC family of DNA polymerase

OCT 17, 2000- Dr. Yoshihiro Matsumoto - Fox Chase Cancer Center,
Philadelphia, PA -Functions of PCNA in Base Excision Repair

SEPT 19, 2000 - Dr. Kenneth Kraemer, NCI, Bethesda, MD  -Clinical and
Molecular Features of Xeroderma Pigmentosum and Related Disorders of DNA
Repair

JUNE 20, 2000- Dr. Richard Setlow , Brookhaven National Lab- Reflections
on how I was led into and onto DNA Repair -  Host:  SUNY

MAY 16, 2000  Dr. Veronica Maher, Michigan State Univ - Role of DNA
Replication and Repair in Carcinogen-Induced Human Cell Mutagenesis  Host:
U of Michigan [Note: this talk will be posted after the data presented is
published]

APR 18, 2000 - Dr. Peter Glazer, Yale Univ - Targeted genome modification
via DNA triple helix formation

MAR 21, 2000 - Research reports by 3 Postdoctoral fellows:
Dr. Steffen Emmert, NCI - The xeroderma pigmentosum group C gene leads to
selective repair of cyclobutane pyrimidine dimers rather than 6-4
photoproducts. [See recent paper describing this work: Proc. Natl. Acad.
Sci. USA 97: 2151-2156, 2000]

Dr. Robert Sobol, NIEHS - Mutagenesis and dRP Lyase Activity in DNA
-Polymerase Dependent Base Excision Repair in Mouse Cells [See recent
paper by Dr. Sobol describing this work:  Nature 405, 807-810 (2000)]

Mr. Robert Levine, SUNY -Mutagenesis Induced by Endogenous DNA Adducts in
Human Cells

FEB 15, 2000  Dr Steve Matson, UNC - Two E. coli mismatch repair enzymes,
DNA helicase II and MutL, interact to catalyze efficient unwinding of
duplex DNA

JAN 18, 2000- Dr. John Essigman, MIT - Cellular responses to the DNA
damaging agent cisplatin

Through the miracle of vidotape we now have been able to post most of the
DNA Repair Interest Group videoconferences from 1998 and 1999 on the web
site.  These include talks by Drs. Bogenhagen, Sutherland, Kunkel,
Stefanini, Hanawalt, Matson, Sharan, Kashlev , Fornace, Anderson, Leadon,
Brooks, McKay, Drotschmann, Chu, Thompson, Woodgate, George, Liu and
Grossman

2.      NIH SEMINAR - THURSDAY, MARCH 22 - 12:30 PM
 Genomic Integrity and Double-Strand Break Repair in Mammals. Speaker: Dr.
Maria Jasin, Sloan-Kettering Institute, NY. Bg 37, Rm 6041. (Info:
301-496-9760).

3.      ANNOUNCEMENTS: HUMAN DNA REPAIR GENES LOCATED IN THE HUMAN GENOME
AND LISTED ON THE WEB

Dr. Rick Wood writes:

For your next DNA repair interest group update, it may be useful to note
the compilation of more than 100 human DNA repair genes in the Feb. 16,
2001 issue of Science (291, pp. 1284-1289). This article can be accessed
online.
http://www.sciencemag.org/cgi/content/abstract/291/5507/1284

An online Table with links to Gene Cards and NCBI gives ready access to a
huge amount of information on 127 DNA repair genes and their protein
products. The most recent version of the table is available at:
http://www.cgal.icnet.uk/DNA_Repair_Genes.html

Dr. Wood welcomes suggestions for additions and corrections.

Contact Dr. Wood at r.wood at icrf.icnet.uk


4.    CONFERENCES - PHOTOPROTECTION CONFERENCE;  MIDWEST DNA REPAIR
MEETING; AMERICAN SOCIETY FOR PHOTOBIOLOGY;  FASEB HELICASE MEETING; YEAST
AS A MODEL FOR MITOCHONDRIA-RELATED HUMAN DISORDERS; EUROPEAN SOCIETY FOR
PHOTOBIOLOGY

[Note: A larger and more up-to-date list of conferences can be found on
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

4.1  PHOTOPROTECTION CONFERENCE - KRAKOV, POLAND, MAY 19-22, 2001

The conference on PHOTOPROTECTION (skin and eyes and related topics such
as commercial sunscreens and melanins) I am organizing with Prof Tad Sarna
at the Jagiellonian University, Krakov, Poland from 19-22 May .

Please note that should you wish accommodation in an en suite University
room it is quite cheap and good quality but we have only 30 such rooms so
it is first come first served!

Of course, there will be a social programme that will probably include a
welcome reception in the old part of the University, an Italian lunch in a
nearby cafe, a conference dinner and a guided tour of Krakov. As an option
there may be a possibility of a visit to the nearby and famous salt
mine!

If you need any more information please e-mail me at  cha31 at keele.ac.uk

Yours sincerely

George Truscott
Keele University, UK


4.2     THIRD ANNUAL MIDWEST DNA REPAIR SYMPOSIUM: JUNE 2-3, 2001 INDIANA
UNIVERSITY SCHOOL OF MEDICINE, INDIANAPOLIS, IN
        Keynote speakers: Dr. Samuel H. Wilson, NIEHS, Dr. Stanton L.
Gerson, Case Western Reserve Univ.

        More details are on the website:
http://www.iupui.edu/~wellsctr/sympage.htm
        Contact information:
        Drs Mark Kelley and David A. Williams
        TEL: 317-274-2755;      FAX; 317-274-5378;
        e-mail:  mkelley at iupui.edu

4.3   2001 ANNUAL MEETING OF THE AMERICAN SOCIETY FOR PHOTOBIOLOGY:JULY
7-12, CHICAGO

It is my pleasure to invite you to the 2001 Annual Meeting of the American
Society for Photobiology, which will be held at the downtown Chicago
Marriott Hotel on July 7-12. The meeting has been organized taking into
account the interests and needs of all ASP members. A unique variety of
invited lectures, symposia, and award presentations will be important
parts of our meeting. The real success of each ASP meeting, however, is
largely related to the attendance and participation by our membership.
Platform and poster presentations, which provide new information on a wide
range of photobiology topics of interest to our members, will be an
integral part of the 2001 ASP meeting.

For the convenience of our members, we will be using on-line abstract
submission and registration for the Chicago meeting. Please note that the
deadline for receipt of abstracts has been extended to March 15. Student
travel awards will again be offered and I invite all members to encourage
their students and trainees to apply for a 2001 ASP travel award.
Informational material for the meeting has been sent to all members.
Additional information on the 2001 ASP meeting can be found at the
Photobiology Website: www.POL-US.net. I look forward to seeing all of you
in Chicago in July!

Charles J. Gomer
Scientific Program Chairman

4.4     HELICASES: STRUCTURE, FUNCTION AND ROLES IN HUMAN DISEASE  -JULY
7-12, 2001  VERMONT ACADEMY,  SAXTONS RIVER VERMONT

A FASEB helicase meeting to be held July 7-12, 2001 at the Vermont
Academy, Saxtons River Vermont.

Session subtopics include:
Helicase Structure
Helicase Function and Mechanism
Helicases in DNA Replication
Helicases in DNA Repair and Recombination
RNA Helicases in Transcription, Splicing, RNA stability and transport
RNA Helicases in Translation and  Ribosome Biogenesis
Helicases as part of macromolecular machines
Helicases in Viral Replication
Helicases in Cancer and Aging.

This will be the first meeting held in the United States dedicated
entirely to helicases.   Further information can be obtained from meeting
organizers:  Sandy Weller, University of Connecticut HealthCenter,
weller at nso2.uchc.edu, 860-679-2310 and Steve Matson, Univeristy of North
Carolina smatson at bio.unc.edu, 919-962-0005.  Vice-chairs will be Anna
Marie Pyle (amp11 at columbia.edu) and Smita Patel (patelss at umdnj.edu).
Please pass on to colleagues who may be interested.


4.5 YEAST AS A MODEL FOR MITOCHONDRIA-RELATED HUMAN DISORDERS -AUGUST
25-26, 2001 - PRAGUE, CZECH REPUBLIC

In Honor of Piotr P. Slonimski and his seminal work in mitochondrial
genetics

August 25-26, 2001
Prague, Czech Republic

To be held shortly before the opening of the "XXth International
Conference on Yeast Genetics and Molecular Biology (ICYGMB)".

Organizing Committee:
J. Houtek (Prague), J. Kolarov (Bratislava), Robert Naviaux (San Diego)
and Keshav Singh (Baltimore)

All necessary information and further details about the symposium will be
included soon on the web site of the XXth ICYGMB
(http://www.biomed.cas.cz/yeast2001/). The organizers kindly ask those who
are interested to participate in the symposium to follow the web site and
to spread this information to all potential participants.

Abstracts and registration should be submitted via the e-mail address
mito at biomed.cas.cz
to:
****************************************************************************
**
MITO 2001 Secretariat
Institute of Physiology
Academy of Sciences of the Czech Republic
Videnska 1083, 142 20 Prague 4
Czech
Republic********************************************************************
**********

For questions and remarks contact:

kolarov at fns.uniba.sk
Jordan Kolarov
Department of Biochemistry, Faculty of Sciences, Comenius University Ml.
Dolina CH-I,
SK-842 15 Bratislava Slovakia
Phone: +421-7-602 96 539 Fax: +421-7-602 96 452

houstek at biomed.cas.cz
Josef Houstek
Department of Bioenergetics, Institute of Physiology, Academy of Sciences
of the Czech Republic, Videnska 1083, 142 20 Praha 4, Czech Republic,
Phone: +420-2-475 2434 Fax: +420-2-475 2149

4.6   9TH CONGRESS OF THE EUROPEAN SOCIETY FOR PHOTOBIOLOGY - SEPTEMBER
3-8, 2001, LILLEHAMMER, NORWAY

The 9th Congress of the European Society for Photobiology will be arranged
in Lillehammer, Norway, 3 - 8 September 2001. It is a pleasure to welcome
you to the Congress and to invite you to submit an abstract. The Congress
home page where the Second Announcement and Call for Abstracts can be
found, has the address  http://esp.nrpa.no , and information can also be
found on www.pol-us.net or www.pol-europe.net.

You may also obtain additional information and a paper copy of the Second
Announcement by writing to the Congress Secretariat: P.O.Box 55, NO-1332
Osteras,
Norway.

I'm looking forward to seeing you in Lillehammer.

Best regards

Terje Christensen
(Chairman of the Local Organising Committee)


5.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Baltimore, MD; Burlington,
VT; Boston, MA; Bethesda, MD; Smithville, TX; Indianapolis, IN; San
Francisco, CA; Brookhaven National Labs; Gaithersburg, MD; Bethesda, MD;
[Note: Check the list for more Job Opportunities on the DNA Repair
Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ ]




5.1 TENURE TRACK INVESTIGATOR NATIONAL INSTITUTE ON AGING - BALTIMORE

The Intramural Research Program of the National Institute on Aging,
Baltimore, Maryland, is recruiting a tenure track investigator for the
Laboratory of Molecular Genetics (LMG).  The individual is expected to
develop an independent research program with a basis in DNA repair and an
interest in immunology and aging.

Candidates with extensive experience in the molecular biochemistry of DNA
repair in mammalian models are encouraged to apply.  Applicants must have
a strong record of scientific accomplishments including publication
record, excellence in laboratory research, a history of independent
research accomplishments and a reputation in their research area.

Current research in the Laboratory is focused on DNA repair in human
premature aging syndromes, oxidative DNA damage, processing helicase
functions and gene targeting.

Applicants should send a curriculum vitae, three letters of reference, and
a statement of research interests to:

Chair, LMG Tenure Track Search Committee,
c/o Pat Boyce, HR Staff Office,
National Institute on Aging, NIH,
Box 26,
5600 Nathan Shock Dr.,
Baltimore, MD 21224-6825.

Attn:  VA# NIA- 01-004.

For further information E-mail Dr. V. Bohr, Chief, LMG at vbohr at nih.gov.

Applications must be postmarked by  April 19, 2000.  NIH is an Equal
Opportunity Employer.

5.2      POSTDOCTORAL POSITIONS AVAILABLE AT THE UNIVERSITY OF VERMONT
1. To use X-ray crystallographic approaches to study the interactions
between DNA lesions and DNA polymerases and DNA repair glycosylases-two
positions with four years of funding available

2. To use cell biological and biochemical approaches to determine the role
that base excision repair plays in the processing of radiation damage and
its consequences in mammalian cells - two positions with multiple year
funding available

Successful applicants would part of an interactive multidisciplinary group
studying oxidative DNA damage processing using a variety of approaches.
The Department and University environments are collegial and supportive.
There is a strong postdoctoral and graduate student community here and
Burlington is an easy and fun place to live. Prior postdoctoral fellows
have been very successful in obtaining academic and/or industrial
positions.

Interested applicants should send CV and names of three references to:

Dr. Susan Wallace
Department of Microbiology and Molecular Genetics
University of Vermont
Burlington, Vt. 05405

swallace at zoo.uvm.edu
802-656-2164



5.3      POSTDOCTORAL OPPORTUNITIES IN RADIATION BIOLOGY/DNA REPAIR AT THE
HARVARD SCHOOL OF PUBLIC HEALTH

Web site: http://www.hsph.harvard.edu/ccb/rb/

This program is supported by the National Cancer Institute to provide
research training in modern Radiation Biology.  The program covers a broad
array of subjects conducted in internationally recognized laboratories:

 cell biology of radiation effects
 cellular responses to free radicals and stress
 checkpoint activation and cellular responses to DNA damage
 DNA repair and radiation mutagenesis
 mechanisms of apoptosis activation
 molecular epidemiology
 development of novel radiotherapy agents

The training program is based in Department of Cancer Cell Biology of the
Harvard School of Public Health, but preceptors are also located at the
Medical School, representing the Division of Nuclear Medicine and the
Department Radiation Oncology, and at the Dana-Farber Cancer Center, the
Brigham and Women's Hospital, the Beth Israel-Deaconess Medical Center,
and the Massachusetts General Hospital.

A major strength of this program is the diversity of its faculty and the
opportunity for fellows to interact with world-class scientists and
physicians in the Harvard biomedical research complex.  In addition, the
Harvard School of Public Health and Harvard Medical School provide a
unique environment with state-of-the-art core facilities for cellular and
molecular analysis, data processing, and outstanding libraries and other
support services.  The Boston area is an excellent location for young
scientists, with top colleagues in all disciplines and visiting lecturers
from around the world.

Applicants must have a PhD in biology, biophysics, or related sciences, or
an MD, DVM, or other suitable degree.  Applicants must be citizens or
permanent residents of the United States.  The training program consists
of 2-3 years of laboratory research and training under one of the
preceptors, including opportunities to present research accomplishments at
local, national, and international meetings.  Past trainees have obtained
leadership positions in academic, government and industrial research.

Please contact a preceptor directly or send a curriculum vitae and the
names and addresses of three references to:

Professor Bruce Demple, Director
Radiation Biology Training Program
Department of Cancer Cell Biology
Harvard School of Public Health
665 Huntington Avenue
Boston, MA  02115

E-mail: bdemple at hsph.harvard.edu


5.4 NIH POSTDOCTORAL POSITIONS AVAILABLE

Postdoctoral Positions (3) are available with the Nuclear Medicine
Department, National Institutes of Health, Bethesda, MD to study the
molecular and cellular effects of ionizing radiation. Current research
interests include DNA repair mechanisms, particularly DNA double-strand
break repair, structural analysis of radiation induced DNA damage, and
methods for production of positioned radiation damage in nucleic acids.

Candidates should possess a recent Ph.D., M.D., or equivalent degree (5 or
fewer years postgraduate). Experience in molecular biology, biochemistry,
or nucleic acid chemistry is a plus. Please send a CV with the names and
contact information for 3 references, along with a brief description of
your research experience to:

Dr. Thomas A. Winters
Bldg. 10, Room 1C401
10 Center Drive
Bethesda, MD, 20892-1180
email: twinters at mail.nih.gov
Fax: 301-480-9712


5.5    POSTDOCTORAL POSITION- UNIVERSITY OF TEXAS M.D. ANDERSON CANCER
CENTER, SCIENCE PARK-RESEARCH DIVISION, DEPARTMENT OF CARCINOGENESIS
A position is available for a doctoral scientist with U.S. citizenship
with interest and experience in the study of DNA damage and mutation.  The
project is funded by the Life in Extreme Environments program at NSF and
will involve studies on the relationship between DNA degradation and
speciation in glacial bacteria.  Experience with Comet assay, bacterial
genetics, or mismatch repair would be helpful.  If interested please
contact (by phone or email):

David L. Mitchell, Ph.D.
Associate Professor Department of Carcinogenesis
The University of Texas M.D. Anderson Cancer Center
Science Park/Research Division
P.O. Box 389 Smithville, TX 78957
Phone: (512) 237-9474 Email: dmitch at io.com

5.6      POSTDOCTORAL POSITIONS INDIANA UNIVERSITY MEDICAL SCHOOL -
DNA REPAIR

Postdoctoral positions are immediately available to conduct
molecular,biochemical, cellular, and gene therapy studies in the area of
DNA baseexcision repair (BER).

Projects include use of DNA BER genes in gene therapy, either for cell
protection or tumor cell killing; analysis of BER expression in
neuralcells; use of BER genes to prevent oxidative DNA damage.

Please send curriculum vitae, a brief statement of research experience and
the names, addresses and telephone numbers of three references to:

Dr. Mark R. Kelley
Professor, Dept. of Pediatrics
Herman B Wells Center for Pediatric Research
Section of Hematology/Oncology
Indiana University Medical School
702 Barnhill Dr.
Indianapolis, IN 46202
Telephone: 317-274-2755
FAX: 317-274-5378
email: mkelley at iupui.edu

Equal Opportunity/Affirmative Action Employer.


5.7      POSTDOCTORAL POSITION AT UCSF CANCER CENTER, SAN FRANCISCO

        Position available immediately, for research involving DNA repair
and error-prone DNA polymerases, recombination, genomic changes associated
with malignancy, and transgenic animal models of repair defective diseases
involving cancer and neurodegeneration (XP, CS etc).
UCSF Cancer Center has excellent state-of-the-art support services in gene
expression arrays, molecular cytogenetics, and transgenic animals.
Experience in molecular biology, especially vector construction, required.

Salary: NIH postdoctoral level plus supplement for San Francisco. US
citizens or immigrant visa required.

Contact:
James E. Cleaver, PhD
Box 0808,
UCSF Cancer Center,
University of California,
San Francisco, CA, 94143.
Fax 415-476-8218. E-mail: jcleaver at cc.ucsf.edu
Send resume and 3 references. UCSF is an equal opportunity employer.


5.8      POST-DOCTORAL POSITION STUDYING DNA DAMAGE CLUSTERS: BIOLOGY
DEPARTMENT, BROOKHAVEN NATIONAL LABORATORY

Postdoctoral position for recent Ph.D., studying molecular aspects of
induction and repair of DNA damage clusters in mammalian cells. {See our
recent publications: Sutherland et al. (2000) DNA Damage Clusters Induced
by Ionizing Radiation in Isolated DNA and in Human Cells, Proc. Natl.
Acad. Sci. U.S.A. 97:103-108; Sutherland et al., (2000) Clustered Damages
and Total Lesions Induced in DNA by Ionizing Radiation: Oxidized Bases and
Strand Breaks, Biochemistry, 39:8026-8031}.  New position in highly
interacting, multi-expertise group of Betsy Sutherland, Biology
Department, Brookhaven National Lab, in collaboration with Jacques Laval,
Institut Gustav Roussy, France. Requires Ph.D. or equivalent in radiation
biology/biochemistry or molecular biology. Good communication skills and
ability to interact with scientists, professional staff and students of a
wide variety of backgounds essential. Potential for participation in
NASA-funded Heavy Ion Radiobiology program at BNL.  Must be willing to
travel to collaborating institutions.  One year initial appointment, with
possibility of renewal.
For more information or to apply, send your C.V., description of your
research experience and interests, and names, addresses, telephone numbers
and email addresses of at least three references to:
Dr. Betsy Sutherland,
Biology Department,Brookhaven National Lab,
Upton, Long Island, New York 11973
TEL: 631 344-3380; FAX 631 344-3407
email:bms at bnl.gov.
BNL is an equal opportunity employer; women and minorities are especially
encouraged to apply.



5.9  EMPLOYMENT OPPORTUNITIES IN PHARMACOGENETICS -NOVARTIS
PHARMACEUTICALS CORPORATION,  GAITHERSBURG, MD

Senior Scientists
(3 Positions in Gaithersburg, MD)
The successful candidates will be part of a team that is focusing on the
study of genetic factors underlying drug response, utilizing the latest
cutting edge technologies. Responsibilities will include management of
projects, analysis of gene expression and genotyping data, publishing, and
patent application.
Minimum Requirements: Ph.D. in cell biology, biochemistry, human genetics
or a related field. Strong knowledge of drug metabolism, signal
transduction pathways, and experience in gene expression profiling and
patent writing are a plus.
These positions require excellent communication skills and the ability to
work efficiently within a team environment. Demonstrated record of
scientific publishing desirable.

Bioinformatics: Systems Analyst/Programming
(3  Positions in Gaithersburg, MD)
The successful candidates will be involved in the design and development
of scientific web database applications in close collaboration with
scientists.
Minimum Requirements: College education and experience with Java, Perl,
SQL, Oracle, PL/SQL, C and CGI. A background in research and genetics is
desired. Experience with Oracle Application Server is a plus.

Assistant Scientists
(4 Positions in Gaithersburg, MD)
The successful candidates will be involved in high throughput genotyping
and gene expression profiling, positional cloning of complex disease genes
and mutation analysis of candidate genes. Technologies used include
general molecular genetics protocols, DNA/RNA extraction, PCR, sequencing
and cloning, microarray analysis.
Minimum Requirements: B.S. in Molecular Biology, or related field.
Candidates should have excellent organizational skills, be efficient and
dependable. Ability to adapt to new technologies and to work in a high
throughput and challenging environment is essential.

At Novartis Pharmaceuticals Corporation we offer excellent compensation
and benefits programs that reflect our position as industry leaders. The
programs include medical, dental, vision, legal and financial planning
services, life insurance, 401K as well as leadership development
initiatives. Find out how fulfilling your career can be.
For more information about us, visit our website at novartis.com or
forward your resume/curriculum vitae and letter of interest to Novartis
Pharmaceuticals Corp. Pharmacogenetics 9 West Watkins Mill road,  room
264. Gaithersburg, MD 20878. We are an equal opportunity employer M/F/D/V.
We appreciate your interest in our company. Unfortunately, we will only be
able to respond to those candidates chosen for interviews or additional
follow-up.

5.10            POST-DOCTORAL POSITION - BETHESDA, MD: DNA REPLICATION

A postdoctoral position is available in the laboratory of Dr. Mirit I.
Aladjem at the National Cancer Institute, Bethesda, MD to study the
regulation of  DNA replication origins in mammalian cells.  The aim of the
research program is understanding how information from the cell cycle
machinery leads to the initiation of DNA replication.  The proposed
project is based on the observation (1) that in some mammalian loci,
initiation sites are determined by interaction between local sequences at
the origin of replication and distant regulatory sequences.   A recently
developed intrachromosomal initiation assay (2), combining biochemical
analysis with recombinase-mediated gene targeting (3) will be used to
evaluate the local and distant requirements for initiation.  We will then
be able to determine the cell cycle regulatory pathways that interact with
these sequences in normal and malignant cells.

The position is located in Bethesda, Maryland, a suburb of Washington,
D.C.  Applicants with a background in molecular biology and an interest in
DNA replication, cell cycle and mechanisms of carcinogenesis are
encouraged to contact the email address or the phone number below, or
Email:  aladjemm at mail.nih.gov

Mirit I. Aladjem, Ph.D.
Laboratory of Molecular Pharmacology
DBS/NCI/NIH
Bldg. 37,  Rm 5D09
37 Convent Dr.
Bethesda, MD 20892-4255
Tel. 301-435-2848; Fax  301-402-0752



6.      ELECTRONIC CONTACTS:
6.1     Check out the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
You can find the schedule for future DNA Repair Interest Group
videoconferences and a listing of past videoconferences (with links to the
videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair
and MEETING NOTICES.

6.2     Encourage your colleagues who are interested in DNA Repair to
request that they be added to this DNA Repair Interest Group listserve
e-mail list by sending a request by e-mail to: listserv at list.nih.gov
Leave the subject  blank. In the message field, type in: subscribe
DNARepair-L your name
        Alternatively, by filling out the form on the website you can both
add your name to the e-mail list and have your name posted on the website.
If you want your name to be listed you can fill out the "Join the SIG"
form on the web site and add your name to the listing of members.  If you
are not at NIH then be sure to click the "other" box and then fill in the
name of your institution.

6.3     Archives of these listserve mailings can be found at
        http://list.nih.gov/archives/dnarepair-l.html
                or via links from the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/

6.4     I will be happy to relay information about post-doctoral
positions, jobs and meetings and other information related to DNA Repair.
Please send me an e-mail message (kraemerk at nih.gov) and I will incorporate
it into the next announcement list and post it on the DNA Repair Interest
Group web site: http://www.nih.gov:80/sigs/dna-rep/ .
(This list goes to more than 700 scientists around the world who are
interested in DNA repair.)




Kenneth H. Kraemer, M.D.
Basic Research Laboratory
National Cancer Institute
Building 37 Room 3E24
Bethesda,  MD 20892
301-496-9033    FAX: 301-496-8419
e-mail: kraemerk at nih.gov
DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/


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