FW: DNA Repair Interest Group -UPDATE - December 11, 2002

Charles Miller rellim at tulane.edu
Fri Dec 13 11:42:51 EST 2002


------ Forwarded Message
From: "Kenneth H. Kraemer" <khk at nih.gov>
Reply-To: Ken Kraemer <kraemerk at nih.gov>
Date: Wed, 11 Dec 2002 17:53:08 -0500
To: DNAREPAIR-L at LIST.NIH.GOV
Subject: DNA Repair Interest Group -UPDATE - December 11, 2002

DNA Repair Interest Group -UPDATE - December 11, 2002

1.      VIDEOCONFERENCE - Dec 17, 2002 - Tues 12:30PM - Dr. John Tainer-
Conformational Controls and DNA Repair Coordination
2.      XERODERMA PIGMENTOSUM AND COCKAYNE SYNDROME HUMAN MUTATION
DATABASE WEBSITE
3.      CONFERENCES - Gordon Conference on Mammalian DNA Repair;
International Congress of Photochemistry; DNA Repair and Mutagenesis: from
Molecular Structure to Biological Consequences; International Congress of
Photobiology
4.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Boston, MA; Upton, NY;
Portland, OR; Ontario; Boston, MA; Saskatchewan, Canada;  Lyon, France;
Washington, D.C.; Pittsburgh, PA
5.      COMMERCIAL REAGENT SOURCES
6.      Electronic Contacts


1.0     DNA REPAIR VIDEOCONFERENCE:

Dec 17, 2002 - Tues 12:30PM - Dr. John Tainer, UC Berkeley -
Conformational Controls and DNA Repair Coordination - Origin: Livermore

VIDEOCONFERENCE LOCATIONS:  Building 45 (NATCHER) Room H, Bethesda, MD;
Lawrence Livermore Labs, Livermore, CA (origin); Univ of Michigan, Ann
Arbor; University of Pittsburgh; MD Anderson, Smithville, TX; Building 101
Room B200, NIEHS, Research Triangle Park, NC; State University of New
York, Stony Brook, NY; Room 1E03 GRC Baltimore, MD; Univ of Kentucky,
Lexington, KY; Building 549, Conference Room A,  FCRDC, Frederick, MD;
Brookhaven National Labs, Upton, NY; Univ of Texas, Galveston (WELCOME TO
OUR 12TH SITE!) and live on the internet at http://videocast.nih.gov


1.1     DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE
[Note: A larger and more up to date list of future and past
videoconferences can be found on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

1.1.1 FUTURE VIDEOCONFERENCES:

Jan 21, 2003 - Tues 12:30PM - Dr. Jack Taylor, NIEHS - Epidemiologic
studies of DNA repair gene polymorphisms and cancer risk  - Origin: NIEHS

Feb 18, 2003 -Tues 12:30PM - Dr. Susan Wallace, Univ of Vermont -
Processing of
oxidative DNA damage - Origin: Baltimore

Mar 11, 2003 - Tues 12:30PM- Dr. Sankar Mitra, Univ of Texas, Galveston -
Oxidative Damage Repair and Its Co-ordination in the Mammalian Genome. -
Origin: Bethesda

Apr 15, 2003 - Tues 12:30PM - Dr. Qingyi Wei, M.D. Anderson, Houston, Tx -
DNA Repair Function, Polymorphisms and Cancer Risk in the General
Population - Origin: Smithville

May 20, 2003 - Tues 12:30PM- Dr. Errol Friedberg, Univ of Texas
Southwestern, Dallas, Tx - History of DNA Repair - Origin: Smithville

June 17, 2003 - Tues 12:30PM - Talks by Post Doctoral Fellows


1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE):
To date 50 of these videoconferences have been archived and are available
for viewing at your leisure on the internet. You will need a web browser
(with a high speed link) and free Real Video software.  Setup details and
access are available at the NIH videocast website:
http://videocast.nih.gov. Go to Past events; DNA Repair Interest Group
Sessions.

Note: Technical improvements are made regularly on this site to increase
transmission speeds and ease of access. If you were not successful in
viewing these videos in the past it is worth trying again!

Nov 12, 2002 - Dr. Rob Sobol, Univ of Pittsburgh - DNA Base Damage and
Repair Intermediates: Out of the Pan and into the Fire [Note: The posting
of this talk will be delayed at the request of the speaker.]

Oct 15, 2002 - Dr. Al Fornace, NCI - Convergence of the p53 and MAP kinase
stress signaling pathways after UV radiation

Sept 17, 2002 - Dr. Dale Ramsden, UNC - DNA Double strand break repair
[Note: at the request of the speaker posting of this videoconference will
be delayed]

June 18, 2002 - Dr. David Chen - Lawrence Berkeley National Lab - Role of
DNA-PK in Cellular Responses to DNA damage

May 21, 2002 -  Dr. Mark J. Schofield - NIH, Bethesda - DNA mismatch
repair; Dr. Sunitha Yanamadala - Univ of Michigan - Role of Mismatch
Repair Proteins in Signaling p53 and Apoptosis; Dr. Federica Marini - Univ
of Pittsburgh - A human DNA helicase homologous to the DNA crosslink
sensitivity protein mus308

Apr 16, 2002 -  Dr. Philip Hanawalt - Half a century of DNA repair: An
historical perspective

Mar 19, 2002 - Dr. Alan Tomkinson - Univ of Texas, San Antonio -
Mechanisms of DNA End Joining

Feb 19, 2002 - Dr. Yves Pommier - NCI - Nucleotide excision
repair-dependent cytotoxicity of a novel anticancer agent, ecteinascidin
743

Jan 15, 2002 - Dr. Tom Kunkel- NIEHS - Recent studies of DNA Mismatch
Repair

Dec 18, 2001 -  Dr. Richard Wood - Univ of Pittsburgh- Tolerating damaged
DNA

Nov 13, 2001 - Dr. J. Christopher States - University of Louisville-
Cisplatin regulation of XPA expression in ovarian cancer cells [Note: This
conference was just posted!]

Oct 24, 2001 -UV, p53 AND SKIN CANCER- Douglas E. Brash, Ph.D., Yale
University, New Haven, CT.    This 30 min videotape was presented to the
Royal College of  Pathologists, London, England.

Oct 16, 2001 - Dr. Daniel Yarosh - Applied Genetics - Reduction of Skin
Cancer in XP Patients Treated Topically with DNA Repair Enzymes

June 19, 2001 - Dr. James Cleaver -Univ of California, San Francisco, CA -
History of DNA Repair - Mending Human Genes

Through the miracle of videotape we now have been able to post most of the
DNA Repair Interest Group videoconferences from 1998,1999, 2000 and 2001
on the web site.  These include talks by Drs. Anderson, Beernik,
Bogenhagen, Bohr, Brooks, Brosh, Chu, Copeland, Drotschmann, Emmert,
Essigman, Fornace, George, Glazer, Grossman, Hanawalt, Jin, Kashlev,
Kraemer, Kunkel, Leadon, Liu, Ljungman, Matson, Matsumoto,  McKay,
Setlow, Sharan, Sobol,  Stefanini, Sung, Sutherland, Thompson, Wang, and
Woodgate.

2. XERODERMA PIGMENTOSUM AND COCKAYNE SYNDROME HUMAN MUTATION DATABASE
WEBSITE

A new website is now open listing most currently known mutations in the
xeroderma pigmentosum and Cockayne syndrome genes:  http://xpmutations.org
This website contains brief summaries of DNA repair, the individual genes,
a map of mutations, and a searchable database for each mutation and cell
line in the open literature. It contains a mechanism for posting comments
and corrections for the author, James E. Cleaver, and will be updated and
corrected as new information is available.


3.    CONFERENCES - Gordon Conference on Mammalian DNA Repair;
International Congress of Photochemistry; DNA Repair and Mutagenesis: from
Molecular Structure to Biological Consequences; International Congress of
Photobiology

[Note: A larger and more up-to-date list of conferences can be found on
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

3.1 GORDON CONFERENCE ON MAMMALIAN DNA REPAIR- JANUARY 19-24,2003 -
VENTURA, CALIFORNIA

The program for this conference is now set, see
http://www.grc.uri.edu/programs/2003/mamdna.htm

Registration is now open via the Gordon Conference Web Site. This
conference is always oversubscribed, causing competition for the allocated
places (about 135 total), so register early. (The number of people who can
be admitted from any single institution is limited as a result). The
conference is aiming for a mix of established
investigators, junior investigators, postdocs, and students. Depending on
the success of funding applications, there may be funds available to help
junior investigators with meeting costs, but a firm result on this will
not be known until the time of the conference.

3.2 INTERNATIONAL CONFERENCE ON PHOTOCHEMISTRY, NARA, JAPAN - JULY 26-31,
2003

Dear Colleague;

On behalf of the International Committee and the Local Organizing
Committee it is my great pleasure to invite you the XXIst International
Conference on Photochemistry to be held in Nara, Japan from July 26 to 31,
2003.

The 1st Circular can be found at the www page at
http://dolphin.ap.eng.osaka-u.ac.jp/icp21.html.

If you wish to receive the second circular in December, 2002, please
complete the REPLY FORM at the end of this mail and return it at your
earliest convenience by e-mail (or FAX). The REPLY FORM is also available
in the 1st Circular.

If you have any questions, please feel free to e-mail to the Secretary
General of the
Conference.

Sincerely Yours,
Professor H. Masuhara, Chairperson
XXIst International Conference on Photochemistry
Department of Applied Physics
Osaka University, Suita,
Osaka 565-0871, Japan

Professor K. Obi, Chairperson
XXIst International Conference on Photochemistry
Department of Chemistry
Japan Woman's University, Bunkyou-ku,Tokyo 112-8681, Japan
All correspondence concerning the Conference should be addressed to:
Professor N. Nakashima, Secretary General
XXIst International Conference on Photochemistry
Department of Chemistry, Osaka City University,
Sugimoto, Sumiyoshi, Osaka 558-8585, Japan
E-mail : icp21 at sci.osaka-cu.ac.jp
phone &Fax: +81-6-6605-2552

3.3  DNA REPAIR AND MUTAGENESIS: FROM MOLECULAR STRUCTURE TO BIOLOGICAL
CONSEQUENCES - BERMUDA, DECEMBER 7-13, 2003.

Dear Colleagues,
We are writing to let you know that we will be organizing an ASM
Conference entitled "DNA Repair and Mutagenesis: From Molecular Structure
to Biological Consequences" sponsored by the American Society for
Microbiology to be held at the Fairmont Southampton Princess, Bermuda,
December 7-13, 2003. The conference will bring together the various
subdisciplines that collectively comprise the field of DNA Repair and
Mutagenesis. Meetings of this type have been held at approximately four
year intervals since 1974, the preceding one in this informal series
having been at Hilton Head, South Carolina in 1999, and have played a
critical role in the development of this exciting area of research.

Speakers will include: Genevive Almouzni, Lorena Beese, Serge Boiteux,
Jaap Brouwer, Keith Caldecott, Judith Campisi, Gilbert Chu, Priscilla
Cooper, Titia de Lange, John Diffley, Sylvie Doubli, Jean-Marc Egly,
Stephen Elledge, Tom Ellenberger, Rick Fishel, Marco Foiani, Errol
Friedberg, Robert Fuchs, James Haber, Fumio Hanaoka, Phil Hanawalt, Jan
Hoeijmakers, Peggy Hsieh, Ian Hickson, Stephen Jackson, Maria Jasin, Penny
Jeggo, Joe Jiricny, Roland Kanaar, Richard Kolodner, Stephen
Kowalczykowski, Thomas Kunkel, Tony Leadon, Alan Lehmann, Tomas Lindahl,
Bndicte Michel, Sankar Mitra, Paul Modrich, Leon Mullenders, Tanya Paull,
John Petrini, Louise Prakash, Miroslav Radman, Rodney Rothstein, Leona
Samson, Alain Sarasin, Erling Seeberg, Jesper Svejstrup, John Tainer,
Shunichi Takeda, Kiyoji Tanaka, Graham Walker, Susan Wallace, Stephen
West, Sam Wilson, Richard Wood, Roger Woodgate, and Wei Yang.

Some additional speakers on timely topics will be invited closer to the
date of the meeting, and furthermore, speakers will be chosen from among
the submitted abstracts for shorter presentations.

Careful thought has been given to the choice of the site and the design of
the program so that participants will be able to enjoy the type of
opportunities for informal discussions and interactions that are normally
found only at smaller meetings. A special feature of the meeting will be
travel grants to help support the participation of graduate students and
postdoctoral fellows. Additional information concerning the meeting and
the program is available at: http://www.asmusa.org/mtgsrc/dnarepair2.htm

We hope you will mark these dates on your calendars. We look forward to
seeing you in Bermuda in December 2003!

Best Wishes
Graham Walker, Susan Wallace, and Priscilla Cooper

3.4 INTERNATIONAL CONGRESS ON PHOTOBIOLOGY - JEJU ISLAND, KOREA - JUNE
10-15, 2004.

The 14th International Congress on Photobiology sponsored by the
International Union of Photobiology and hosted by the Korean Society of
Photoscience, Photobiology Association of Japan, and Asia and Oceania
Society for Photobiology will be held June 10-15, 2004, on the island of
Jeju, Korea. Both Korean Society of Photoscience, Korean Photodynamic
Association, and Asia and Oceania Society for Photobiology will also hold
their annual meetings in conjunction with the Congress at the same time.
More details can be found at:
http://photos.or.kr/ICP2004 (ICP is case-sensitive)

I would like to invite you to register to participate in the Congress by
visiting the website and filling out the registration form therein. To
make the Congress successful, your suggestions and contributions are
essential and will be greatly appreciated by the Organizing Committee. In
order to make the Congress scientifically attractive, we plan to organize
nearly 50 symposia and 10 special lectures. In addition, we are planning
to present a national photobiology-society sponsored Plenary Lecture each
day of the
Congress.

The Congress venue is the Island of Jeju. It is one of the most beautiful
islands in the world. It offers many sightseeing and leisure attractions.
Bring your family and friends. You will enjoy it.

See you all here in Jeju, Korea, in Year 2004!

Best wishes,
Pill-Soon Song
Congress President-ICP2004


4.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Boston, MA; Upton, NY;
Portland, OR; Ontario; Boston, MA; Saskatchewan, Canada;  Lyon, France;
Washington, D.C.; Pittsburgh, PA  [Note: Check the list for more Job
Opportunities on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

4.1 POSTDOCTORAL POSITION - ALKYLATION DAMAGE - BOSTON, MA

Postdoctoral position - Biological Engineering Division Massachusetts
Institute of Technology, Boston, MA.  A postdoctoral position is available
in the lab of Leona D. Samson to study the biological effects of
alkylation damage.  Research areas include: (1) exploring the molecular
basis of cellular signaling in response to DNA alkylation damage; (2)
alkylation damage-induced global transcriptional responses; (3) functional
genomic approaches (genomic phenotyping) to identifying novel recovery
pathways; (4) transgenic and knockout mice to study the influence of
alkylation damage on apoptosis, mutation, genome stability and
tumorigenesis; (5) gene therapy approaches to suppressing bone marrow
toxicity.  Experience in biochemistry, molecular biology, cell biology,
DNA repair, or knockout/transgenic mouse technology is desired.

Selected Publications:
Hickman, M. and Samson, L.D. (1999) Role of DNA mismatch repair and p53 in
signaling induction of apoptosis by alkylating agents. Proc. Natl. Acad.
Sci., 96: 10764-10769.
Roth, R.B., and Samson, L.D. (2000) Gene transfer to suppress bone marrow
alkylation toxicity.  Mutation Research, 462:107-120.
Lau, A.Y., Wyatt, M.D., Glassner, G., Samson, L.D., and Ellenberger, T.E.
(2000) Molecular basis for discriminating between normal and damaged bases
by the human alkyladenine glycosylase, AAG. Proc. Natl. Acad. Sci,
97(25):13573-13578.
Jelinsky, S., Estep, P., Church, G., and Samson, L. D. (2000) Regulatory
networks revealed by transcriptional profiling of damaged Saccharomyces
cerevisiae cells:  Rpn4 links base excision repair with proteasomes,
Molecular and Cellular Biology, 20 (21):8157-8167.
 Roth, R. and Samson, L.D. (2002) 3-methyladenine DNA
glycosylase-deficient Aag null mice display unexpected bone marrow
alkylation resistance, Cancer Research 62, 656-660.
Begley, T.J., Rosenbach, A.S., Ideker, T. and Samson, L.D. (2002) Recovery
Pathways in S. cerevisiae Revealed by Genomic Phenotyping and Interactome
Mapping, Molecular Cancer Research, in press
Begley T.J. and Samson, L.D. (2003) AlkB mystery solved:  Oxidative
demethylation of N1-methyladenine and N3-methylcytosine adducts by a
direct reversal mechanism, Trends in the Biochemical Sciences, in press

Please send CV and 3 letters of Reference to:
Leona D. Samson
Ellison American Cancer Society Research Professor
Biological Engineering Division, and
Director of the Center for Environmental Health Sciences
Massachusetts Institute of Technology
77 Massachusetts Avenue, 56-235
Cambridge, MA 02139
or via email: lsamson at mit.edu

4.2 POSTDOC: DNA DAMAGE CLUSTERS - UPTON, NY

Postdoctoral position for recent Ph.D., studying molecular aspects of
induction and repair of DNA bistranded damage clusters in mammalian cells.
New position in highly interacting, multi-expertise group of Betsy
Sutherland, Biology Department, Brookhaven National Lab, Upton, Long
Island, New York 11973.

Our research focuses on five key aspects of bistranded cluster prevalence,
induction, repair, and significance: (1) relation of endogenous clusters
to cell survival and repair, (2) mechanisms of cluster repair and the
effect of overproducing or knockout of repair enzymes, (3) probing the
complexity of clusters produced by different types of radiation, and (4)
clusters produced by high LET particles and countermeasures to their
biological effects.

For some recent publications, see Sutherland, B.M, Bennett, P.V.,
Sidorkina, O, and Laval, J.  (2000) DNA Damage Clusters Induced by
Ionizing Radiation in Isolated DNA and in Human Cells,  Proc. Natl. Acad.
Sci. U.S.A. 97:103-108;  Sutherland, B.M., Bennett, P.V., Sutherland, J.C.
and Laval, J. (2002) Clustered DNA Damages Induced by X-rays in Human
Cells, Radiation Research, 157, 611-616;  Song, J.M., Milligan, J.R., and
Sutherland, B.M. (2002) Oxidized Purine Damage Clusters: Induced in DNA by
Long Wavelength Ultraviolet (290-400 nm) Radiation? Biochemistry
41:8683-8688; Georgakilas, A.G., Bennett, P.V. and Sutherland, B.M. (2002)
High efficiency detection of bistranded abasic clusters in g-irradiated
DNA by putrescine. Nucleic Acids Research, 30:2800-2808.  Potential for
participation in NASA-funded Heavy Ion Radiobiology program at BNL.  Must
be willing to travel to collaborating institutions.  Good communication
skills and ability to interact with scientists, professional staff and
students of a wide variety of backgounds essential.  Requires Ph.D. or
equivalent in radiation biology, biochemistry or molecular biology.

For more information, contact Betsy Sutherland (bms at bnl.gov); phone 631
344-3380; FAX 631 344-3407). BNL is an equal opportunity employer; women
and minorities are especially encouraged to apply.

4.3 POSTDOCTORAL POSITION-NERVOUS SYSTEM DNA REPAIR, Portland, OR

A postdoctoral position is available immediately to study the role of DNA
damage and DNA repair in the nervous system. Particular emphasis is on
understanding the role of BER and NER in maintaining the integrity of
neurons and other cell types of the central nervous system. Currently
funded projects involve the use of whole animal and cell culture models
from transgenic/knockout DNA repair mutant mice to explore the
relationship between neuronal cell death and DNA damage during development
and in age-related neurodegenerative disease (e.g., Parkinson's,
Alzheimer's, and Lou Gehrig's disease). PhD candidates (less than 5 yrs
experience) with a strong background in molecular or cell biology and DNA
repair and experience in mammalian cell culture, protein biochemistry,
gene expression, protein-protein interaction, DNA microarrays are
encouraged to apply.

For more information, send an email to the address below. To apply, please
send your C.V., a description of your research experience, and the names,
addresses, telephone numbers and email addresses of three references to:


Glen Kisby, PhD
Associate Professor
Ctr for Res on Occup
& Environ Toxicol (CROET)
Oregon Health & Science University (OHSU)
3181 SW Sam Jackson Park Rd
Portland, OR 97201-3098
E-mail: kisby at ohsu.edu

Portland is an affordable centrally located city in the beautiful state of
Oregon. The University is only 1 h away from year round skiing at Mt Hood,
the Pacific Ocean, and the scenic deserts of eastern Oregon. The campus
contains a large group of distinguished faculty with special emphasis on
the nervous system. CROET is a unique research institute with faculty that
conduct applied research in the workplace (i.e., epidemiology) and basic
research at the cellular and molecular level.


4.4 POSTDOCTORAL POSITION IN MAMMALIAN DNA REPAIR DEPARTMENT OF BIOLOGY,
McMASTER UNIVERSITY, ONTARIO, CANADA

A postdoctoral position is available immediately to study the DNA repair
pathways in mammalian cells. Our laboratory is particularly interested in
the mechanisms of inducible DNA repair pathways following exposure to UVA,
UVB and UVC and how deficiencies in DNA repair play a role in human
disease. Research areas include the role of several human ERCC genes in
inducible DNA repair as well as several aspects of the DNA repair
deficiency in cells from patients with xeroderma pigmentosum, Cockayne
syndrome, Li-Fraumeni syndrome and ataxia telangiectasia. Our laboratory
has developed a number of techniques to study DNA repair using
adenoviruses as probes and expression vectors and the application of these
techniques to other areas of mammalian DNA repair are also possible
research areas in my laboratory.

The position is initially for one year (minimum starting salary of
$30,000) with the possibility of extension for two further years.
Candidates with a recent Ph.D., a background in cell biology, molecular
biology and genetics, some experience in mammalian cell culture and a good
knowledge of both written and spoken English are encouraged to apply.
Please send a CV and the names and addresses (including email address and
telephone number) of three references to:

Andrew J. Rainbow, Ph.D.
Department of Biology
McMaster University
Hamilton, Ontario L8S 4K1
Canada.

Telephone: (905)-525-9140, ext. 23544
Fax: (905)-522-6066
Email: rainbow at mcmaster.ca
Website:
http://www.science.mcmaster.ca/biology/faculty/rainbow/rainbow.htm

4.5 POSTDOCTORAL/RESEARCH ASSOCIATE POSITIONS - BOSTON

Two openings available immediately to study the role of AP endonuclease in
the cell physiology and biochemistry of DNA base excision repair.  We are
a dynamic group in a young department with lots of opportunity.  The
successful candidate will be smart, enterprising and hard working.  We
need you!
Contact:  Phyllis Strauss, Northeastern University, Boston MA 02115,
e-mail: p.strauss at neu.edu.

4.6 POSTDOCTORAL POSITIONS AT UNIVERSITY OF SASKATCHEWAN, CANADA

Two postdoctoral positions are available immediately. One is to study DNA
postreplication repair and mutagenesis in mammalian cells and in a
transgenic mouse model. The second position is to study molecular
mechanisms of gene regulation in response to DNA damage, using budding
yeast as a model eukaryote.

Candidates with recent Ph.D. and background in biochemistry, cell biology,
molecular biology and genetics are encouraged to apply. Annual salary
begins with $32,000 - $35,000, based on experience. Please send CV and
names of three references with contact information to:

Wei Xiao, Ph.D.,
Professor, Department of Microbiology and Immunology
University of Saskatchewan
107 Wiggins Road
Saskatoon, SK, S7N 5E5 Canada
Tel: 306-966-4308
Fax: 306-966-4311
E-mail: wei.xiao at usask.caWeb
site:http://www.usask.ca/medicine/microbio/xiaow/

4.7 POSTDOCTORAL POSITION: INTERNATIONAL AGENCY FOR RESEARCH ON CANCER
(IARC), LYON, FRANCE

A postdoctoral position is immediately available to join the Unit of
Molecular Carcinogenesis at IARC to study the role of DNA repair proteins
during double-strand break repair, germ cell development, and/or tumour
virus infection in higher eukaryotes.

The position is initially for one year with possibility of extension for
two further years and is suitable for a candidate with a PhD and a solid
background in molecular biology, biochemistry and/or cell biology
(including confocal microscopy). Experience working with proteins is
essential, as is a good knowledge of English, both written and spoken.

Applicants are invited to send their CV and the names and addresses of two
referees to:
Eric Van Dyck (Vandyck at iarc.fr)
Unit of Molecular Carcinogenesis,
International Agency for Research on Cancer (IARC),
150 Cours Albert Thomas,
69372 Lyon Cedex 08, France
(Fax: +33-(0)4-7273 8322).

Please consult the IARC web pages (http://www.iarc.fr) for more
information
on the Unit of Molecular Carcinogenesis.


4.8 POSTDOCTORAL RESEARCH ASSOCIATE - Washington, D.C.
        An NIH funded post-doctoral position is available to investigate
the genetics of melanoma using a new mouse model of UV-induced melanoma
(Nature, 413:271-2, 2001) in particular to investigate the effect of
genetic deficiencies in nucleoside excision repair on melanoma induction.
Our laboratory has had a long term interest in the effects of UV radiation
in skin cancer. We have developed an exciting new model for melanoma which
most closely recapitulates human disease and represents a strong vehicle
for melanoma investigations. The George Washington University Medical
Center is currently expanding its interest in cancer research and through
the George Washington Institute of Biomedical Sciences is affiliated with
Children's National Medical Center, Red Cross Holland Laboratories and The
Institute for Genome Research.  Knowledge of DNA repair a strong
advantage. Excellent command of English is essential.

Please send applications to:
Dr F. Noonan, Professor, Department of Environmental and Occupational
Health, George Washington University Medical Center, Ross Hall, Rm 113,
2300 Eye St., NW, Washington DC, 20037.
Tel: 202 994 3970
email: drmfpn at gwumc.edu or fpn at gwu.edu

The George Washington University Medical Center is an equal opportunity
employer. GWUMC is conveniently located in downtown DC next to the Foggy
Bottom Metro.

4.9 POST-DOCTORAL FELLOWSHIP - DNA REPAIR AND DAMAGE AVOIDANCE -
PITTSBURGH, PA
Mammalian Base Excision Repair
The University of Pittsburgh Cancer Institute
Hillman Cancer Center

A postdoctoral / Research Associate position is available in my lab to
study mammalian DNA repair and damage avoidance. Research areas include:
1)  function of X and Y-family polymerases; 2) signal transduction/cell
cycle checkpoints elicited by DNA damage and repair intermediates; 3) DNA
base damage-induced transcriptional profiles using DNA microarrays and
SAGE; 4) transgenic and knockout/knockin mice to study the role of
polymerases in base excision repair, lesion avoidance, genome stability
and tumorigenesis. [see Sobol et al., Proc Natl Acad Sci U S A 99, 6860-5.
(2002); Sobol et al., Nature 405, 807-10. (2000); Sobol et al., Nature
379, 183-6. (1996)]. Experience in biochemistry, molecular biology, cell
biology, DNA repair, or knockout/transgenic mouse technology is desired.

CV and 3 letters of Reference can be sent to:
Robert W. Sobol, Ph.D.,
Hillman Cancer Center,
5117 Centre Avenue, Room 2.3,
Pittsburgh, PA 15232
or via email: rws9 at pitt.edu.

The Hillman Cancer Center opened in July 2002 in a newly-built,
free-standing 350,000 sq. ft. facility integrating basic, translational
and clinical cancer research with patient care. The Center serves as a
critical resource in the region as UPCI is the only NCI-designated
Comprehensive Cancer Center within a 100-mile radius and one of only six
within 200 miles of Pittsburgh. The Center features a Laboratory Pavilion
devoted to basic research programs in biological therapeutics, immunology,
molecular virology, molecular oncology, and molecular therapeutics and
drug discovery. The Center also features an Ambulatory Pavilion devoted to
treatment, prevention and early detection, screening, genetic counseling,
nutritional counseling, behavioral medicine, grief counseling, and
community outreach. The two pavilions are connected by a three-story
atrium lobby that offers a warm welcome to patients, visitors, physicians,
scientists and staff and that will create synergy between UPCI's rapidly
growing basic research and clinical activities. The Center integrates
full-time faculty with more than 50 office-based oncology practices that
currently exist as part of UPCI's extensive clinical network that treat
more than 25,000 patients annually. State-of-the art facilities include
smallanimal care facility, BSL-3 laboratory, flow cytometry suite and
vector production facilities. Faculty having laboratories in the Hillman
Cancer Center are full members of University of Pittsburgh departments
with ready access to University of Pittsburgh core facilities, graduate
programs and seminar series. The unique collegial and collaborative
research environment at the Hillman Cancer Center promises to promote the
search for fundamental causes and cures for cancers.
http://www.upci.upmc.edu/internet/research/index.html

Located at the confluence of three rivers, Pittsburgh is one of America's
most beautiful and livable cities. Active arts and cultural communities,
renown sports teams and interactions between two major universities,
University of Pittsburgh and Carnegie-Mellon University, make Pittsburgh
an attractive spot for leading researchers, students and post-doctoral
fellows.

The University of Pittsburgh is an Affirmative Action Equal Opportunity
Employer


5. COMMERCIAL REAGENT SOURCES
[Note: There are more commercial reagent sources listed on the DNA Repair
interest group website: http://www.nih.gov:80/sigs/dna-rep/    These
sources are listed as a convenience to our readers and do not constitute
an endorsement of any of these companies or their products.]

5.1 R&D Systems - DNA Damage and Repair Research Reagents

We now offer substrates, enzymes, antibodies, detection kits, and other
reagents for use in DNA damage and repair research endeavors. Please find
specific product information at http://www.rndsystems.com
5.2 SAGE BioVentures, Inc. - Antibodies for research applications.

Products cover virtually every area of biology including apoptosis,
cancer, cardiology, cell cycle/regulation, DNA repair, immune system,
infectious diseases, neuroscience, signal transduction and transcription
factors. Please visit our web site: http://www.sagebioventures.com to
learn more about our many exciting products.


6       ELECTRONIC CONTACTS:
6.1     Check out the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
You can find the schedule for future DNA Repair Interest Group
videoconferences and a listing of past videoconferences (with links to the
videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair
and MEETING NOTICES.

6.2     Encourage your colleagues who are interested in DNA Repair to
request that they be added to this DNA Repair Interest Group listserve
e-mail list by sending a request by e-mail to: listserv at list.nih.gov
Leave the subject  blank. In the message field, type in: subscribe
DNARepair-L your name
        Alternatively, by filling out the form on the website
(http://www.nih.gov:80/sigs/dna-rep/ ) you can both add your name to the
e-mail list and have your name posted on the website.  If you want your
name to be listed you can fill out the "Join the SIG" form on the web site
and add your name to the listing of members.  If you are not at NIH then
be sure to click the "other" box and then fill in the name of your
institution.

6.3     Archives of these listserve mailings can be found at
        http://list.nih.gov/archives/dnarepair-l.html  or via links from
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/

6.4     I will be happy to relay information about post-doctoral
positions, jobs and meetings and other information related to DNA Repair.
Please send me an e-mail message (kraemerk at nih.gov) and I will incorporate
it into the next announcement list and post it on the DNA Repair Interest
Group web site: http://www.nih.gov:80/sigs/dna-rep/ .
(This list goes to more than 900 scientists around the world who are
interested in DNA repair.)


Kenneth H. Kraemer, M.D.
Chief, DNA Repair Section
Basic Research Laboratory
National Cancer Institute
Building 37 Room 3E24
Bethesda,  MD 20892
301-496-9033    FAX: 301-496-8419
e-mail: kraemerk at nih.gov
DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/


------ End of Forwarded Message

---




More information about the Toxicol mailing list