FW: DNA Repair Interest Group -UPDATE - May 6, 2002

Chuck Miller rellim at tulane.edu
Tue May 7 11:00:46 EST 2002


----------
From: "Kenneth H. Kraemer" <khk at nih.gov>
Reply-To: Ken Kraemer <kraemerk at nih.gov>
Date: Mon, 6 May 2002 17:10:16 -0400
To: DNAREPAIR-L at LIST.NIH.GOV
Subject: DNA Repair Interest Group -UPDATE - May 6, 2002

DNA Repair Interest Group -UPDATE - May 6, 2002

1.      VIDEOCONFERENCE - May 21, 2002 - Tues 12:30PM - Mismatch Repair,
DNA helicase - 3 talks by post doctoral fellows at different sites
2.      May 8 - Dr. Modrich seminar - DNA Mismatch repair
3.      Passing of David B. Busch
4.      NEW ON-LINE VERSION OF THE DNA REPAIR MOUSE MUTANT DATABASE
5.      XERODERMA PIGMENTOSUM AND COCKAYNE SYNDROME HUMAN MUTATION
DATABASE WEBSITE
6.      CONFERENCES - Midwest DNA Repair Symposium; IPAC Symposium on
Photochemistry; M.D. Anderson Symposium on Fundamental Cancer Research
7.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD; Camden, NJ;
Seattle, WA; Chapel Hill, NC; United Kingdom; Baltimore, MD; Baltimore,
MD; Pittsburgh, PA; Baltimore, MD
8.      Electronic Contacts


1.0     DNA REPAIR VIDEOCONFERENCE:

May 21, 2002 - Tues 12:30PM -  Dr. Mark J. Schofield - NIH, Bethesda - DNA
mismatch repair; Dr. Sunitha Yanamadala - Univ of Michigan - Role of
Mismatch Repair Proteins in Signaling p53 and Apoptosis; Dr. Federica
Marini - Univ of Pittsburgh - A human DNA helicase homologous to the DNA
crosslink sensitivity protein mus308


VIDEOCONFERENCE LOCATIONS:  Building 45 (NATCHER) Room H, Bethesda, MD;
Univ of Michigan, Ann Arbor; University of Pittsburgh; Lawrence Livermore
Labs, Livermore, CA; MD Anderson, Smithville, TX; Building 101 Room B200,
NIEHS, Research Triangle Park, NC; State University of New York, Stony
Brook, NY; Room 1E03 GRC Baltimore, MD; Univ of Kentucky, Lexington, KY;
Building 549, Conference Room A,  FCRDC, Frederick, MD; Brookhaven
National Labs, Upton, NY and and live on the internet at
http://videocast.nih.gov

1.1     DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE
[Note: A larger and more up to date list of future and past
videoconferences can be found on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

1.1.1 FUTURE VIDEOCONFERENCES:

June 18, 2002 - Tues 12:30PM - Dr. David Chen - Lawrence Berkeley National
Lab - Role of DNA-PK in Cellular Responses to DNA damage


1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE):
Now 44 of these videoconferences have been archived and are available for
viewing at your leisure on the internet. You will need a web browser (with
a high speed link) and free Real Video software.  Setup details and access
are available at the NIH videocast website:  http://videocast.nih.gov. Go
to Past events; DNA Repair Interest Group Sessions.

Note: Technical improvements are made regularly on this site to increase
transmission speeds and ease of access. If you were not successful in
viewing these videos in the past it is worth trying again!

Apr 16, 2002 -  Dr. Philip Hanawalt - Half a century of DNA repair: An
historical perspective

Mar 19, 2002 - Dr. Alan Tomkinson - Univ of Texas, San Antonio -
Mechanisms of DNA End Joining  [Note: Posting of this videoconference will
be delayed at the request of the speaker]

Feb 19, 2002 - Dr. Yves Pommier - NCI - Nucleotide excision
repair-dependent cytotoxicity of a novel anticancer agent, ecteinascidin
743

Jan 15, 2002 - Dr. Tom Kunkel- NIEHS - Recent studies of DNA Mismatch
Repair

Dec 18, 2001 -  Dr. Richard Wood - Univ of Pittsburgh- Tolerating damaged
DNA

Nov 13, 2001 - Dr. J. Christopher States - University of Louisville-
Cisplatin regulation of XPA expression in ovarian cancer cells [Note:
Posting of this videoconference will be delayed at the request of the
speaker]

Oct 24, 2001 -UV, p53 AND SKIN CANCER- Douglas E. Brash, Ph.D., Yale
University, New Haven, CT.    This 30 min videotape was presented to the
Royal College of  Pathologists, London, England.

Oct 16, 2001 - Dr. Daniel Yarosh - Applied Genetics - Reduction of Skin
Cancer in XP Patients Treated Topically with DNA Repair Enzymes

JUNE 19, 2001 - Dr. James Cleaver -Univ of California, San Francisco, CA -
History of DNA Repair - Mending Human Genes

MAY 15, 2001- Dr. Bill Copeland - Laboratory of Molecular Genetics NIEHS -
Family A DNA polymerases in eukaryotic DNA replication and repair

MAR 20, 2001 - Short talks at 3 sites:
Peter Beernink, LLNL - A Second Divalent Metal Ion in the Active Site of a
New Crystal Form of Human Apurinic/Apyridinimic Endonuclease, Ape1, and
its Implications for the Catalytic Mechanism

Yong Hwan Jin, NIEHS - The 3'-5' Exonuclease of DNA Polymerase d is
Redundant with
5'-flap Endonuclease Rad27/Fen1 for Processing of Okazaki Fragments

Robert M. Brosh, NIA - Molecular Interactions of the Werner Syndrome
Protein

FEB 20, 2001 - Dr. Vilhelm Bohr - LMG, NIA, Baltimore, MD -  DNA repair
defects in premature aging disorders

JAN 16, 2001- Dr. Mats Ljungman - Univ of Michigan, Ann Arbor, MI -Stopped
in its tracks - RNA polymerase II as a sensor for DNA damage

Through the miracle of videotape we now have been able to post most of the
DNA Repair Interest Group videoconferences from 1998,1999 and 2000 on the
web site.  These include talks by Drs. Bogenhagen, Sutherland, Kunkel,
Stefanini, Hanawalt, Matson, Sharan, Kashlev , Fornace, Anderson, Leadon,
Brooks, McKay, Drotschmann, Chu, Thompson, Woodgate, George, Liu,
Grossman, Essigman, Emmert, Sobol, Glazer, Setlow, Kraemer, Matsumoto,
Wang, and Sung.

2. May 8, Wed - 1:00PM - LHC, CCR, NCI seminar - Dr. Paul Modrich - Duke
University - Mechanisms of DNA mismatch repair - Building 37 Room 1A19.
For more information: 301-496-2048 [Note: this seminar will not be
videocast]

3. Passing of DAVID B. BUSCH, Ph.D., M.D. - July 25, 1953 - April 11, 2002

It is with great sadness that we announce the passing of our friend and
colleague, Dr. David B. Busch who succumbed to leukemia on April 11 at the
age of 48 years.

David was a remarkable, intelligent, and dedicated person.  He received an
undergraduate degree in biochemistry with distinction in 1974, a masters
in biophysics in 1976 and Ph.D. in biophysics in 1980 all at the
University of California, Berkeley.  His Ph.D. work was performed under
the guidance of Nobel prize winner, Dr. Donald Glaser. He then earned an
M.D. degree in 1982 in a special 2 year program for Ph.D's  at the
University of Miami.  This was followed by residencies in anatomic and
clinical pathology at the University of Wisconsin in Madison which
culminated in his becoming a Diplomate of the American Board of Pathology
in 1986.  The same year he joined the Armed Forces Institute of Pathology
in  Washington, DC where he spent his professional career as a Radiation
Pathologist.

His early DNA repair work was focused at discovering DNA repair mutants in
Chinese hamster cells.  He performed large scale isolation and
characterization of UV sensitive DNA repair mutants of these CHO cells.
This work led to the discovery of rodent cells that were homologues of
several human diseases: xeroderma pigmentosum (XP) complementation group D
(ERCC2), group B (ERCC3), group F (ERCC4), group G (ERCC5), Cockayne
syndrome group B (ERCC6) and Fanconi anemia group G (UV40).  Each of these
cell lines was pivotal in the efforts by several laboratories to clone the
corresponding these human genes.

Over the last 25 years David had an extremely successful interaction with
Dr. Larry Thompson at Lawrence Livermore National Laboratory.   Although
Larry was not a formal member of David's  Ph.D. thesis committee, Larry
provided David with guidance and considered him to be a truly outstanding
graduate student. David always seemed to understand everything and was
able to set high goals for himself and meet them.  David ensured that
mutants were still being sent to Livermore by technicians after he had
gone to medical school.

When the Glaser laboratory closed because of loss of funding, Larry
maintained David's mutant collection in liquid nitrogen for about a decade
until David established his own laboratory in Washington, DC.  David then
systematically analyzed the complete collection and produced a series of
publications that involved collaborations with scientists in the
Netherlands, in Texas, and other places. This extended accomplishment was
a reflection of David's thorough, persistent research style. Larry's lab
benefitted immensely from David's mutants.  Some of the mutant lines have
been in a national repository for many years and will continue to serve
numerous investigators indefinitely.

When Dr. Kenneth Kraemer first met David, Dr. James Cleaver had been
performing clinical diagnostic tests for XP patients in the US.  New
Federal regulations made it difficult for Jim to continue this work in a
research lab.  David, who was a card-carrying pathologist in a
distinguished institution that was familiar with Federal regulations,
stepped in to perform this valuable service.

David put his heart and soul into this important work. He began by
offering testing for XP and then expanded to test for Cockayne syndrome
and trichothiodystrophy.  He tested samples from several hundred patients
over the years.  These results have changed many people's lives.  The
Kraemer laboratory and others around the world are currently performing
further analysis on many of these cells and will be studying them for
years to come.

The laboratory work was only part of his effort.  David soon realized that
the people whose cells he tested were searching for assistance as well.
He regularly visited Camp Sundown, a camp for XP patients, and a similar
group for families with Cockayne Syndrome. He brought his cats and his
good humor to cheer up those affected with XP and CS. He will be greatly
missed.

Sincerely,

Kenneth H. Kraemer, M.D., Bethesda, MD kraemerk at nih.gov

James E. Cleaver, Ph.D., San Francisco, CA jcleaver at cc.ucsf.edu

Larry H. Thompson, Ph.D., Livermore, CA thompson14 at llnl.gov


Cards and letters can be sent to his mother:
Mrs. Barbara Busch, 10 Heather Ave, San Francisco, CA 94118
JSB94118 at aol.com

The family requested that donations in David Busch's memory can be made
to:
The XP Society www.xps.org, or
The Share and Care Cockayne Syndrome network,
http://www.cockayne-syndrome.org ,
or the memorial scholarship fund for David Busch at the San Francisco
Hebrew Free Loan Association   http://www.hflasf.org


Of additional interest:

David Busch maintained a website "Myelodysplasia and me"
 http://members.aol.com/myelodysplasia/index.html that chronicled the
unfortunately rapid  course of his disease beginning from diagnosis as a
precancer in November 2000.

David was fond of exotic cats as can be seen in his other website: "About
Jadzia Cattery and Emony's Exotic Cats" which describe his efforts to
breed exotic Norwegian forest cats and Canadian lynxes
http://members.aol.com/mdserval/cattery.html

David Busch prepared an educational CD "Xeroderma Pigmentosum and Cockayne
Syndrome - A Multimedia Overview" which includes video clips of patients
and researchers .  He also made two educational videotapes: "Cockayne
Syndrome (CS) and Xeroderma Pigmentosum (XP)" and "DNA Repair Disorder:
X-Ray Sensitivity Disorder/Administrative and Regulatory Issues in
Laboratory Diagnosis of DNA  Repair Deficient Patients".  These may be
purchased through the online catalogue of the Armed Forces Institute of
Pathology  https://www3.afip.org/cgi-bin/bookstore.cgi Look in the "Study
Sets" section.


4. NEW ON-LINE VERSION OF THE DNA REPAIR MOUSE MUTANT DATABASE

The  on-line version of the DNA repair mouse mutant database maintained at
University of Texas Southwestern Medical School  is now up and running at
http://pathcuric1.swmed.edu/Research/research.htm

Anyone wishing to contribute new entries should contact:

Errol C. Friedberg, M.D.
Professor and Chair
Department of Pathology
UT Southwestern Medical Center
Dallas, TX 75390-9072
friedberg.errol at pathology.swmed.edu





5. XERODERMA PIGMENTOSUM AND COCKAYNE SYNDROME HUMAN MUTATION DATABASE
WEBSITE

A new website is now open listing most currently known mutations in the
xeroderma pigmentosum and Cockayne syndrome genes:  http://xpmutations.org
This website contains brief summaries of DNA repair, the individual genes,
a map of mutations, and a searchable database for each mutation and cell
line in the open literature. It contains a mechanism for posting comments
and corrections for the author, James E. Cleaver, and will be updated and
corrected as new information is available.


6.    CONFERENCES - IPAC Symposium on Photochemistry; M.D. Anderson
Symposium on Fundamental Cancer Research
[Note: A larger and more up-to-date list of conferences can be found on
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]

6.1 IUPAC Symposium on Photochemistry - Budapest, Hungary, July 14-19,
2002

The home page of the XIXth IUPAC Symposium on Photochemistry is being
updated. You will find all necessary forms and deadlines, including the
form for the submission of abstracts. If you intend to present an oral
contribution, please note the deadline of March 1, 2002. Oral
presentations will be selectedby the International Scientific Committee
(ISC). The home page will be updated from time to time, as needed, so
please check it occasionally.
http://www.photoiupac.hu

Heinz Roth and Jozsef Nyitrai

6.2 55th MD ANDERSON SYMPOSIUM ON FUNDAMENTAL CANCER RESEARCH - HOUSTON,
TX,  OCT 15-18, 2002

The symposium "Maintenance of Genomic Stability" will feature Richard
Kolodner and David Livingston as Keynote Speakers, and also many others in
the fields of DNA repair and the cell cycle. A mailing with registration
and poster abstract information will go out soon.

The meeting info can be found at this site, although you have to scroll
down to find it:
http://www.mdanderson.org/conferences

Here is the full URL:
http://www.mdanderson.org/Cancer_Pro/Pro_Education/display.cfm?id=0BF20C5B-4
914-411F-996E1ED736272D64&method=displayFull

The web site for submitting abstracts is:
http://www3.mdanderson.org/researchsymposium/

Please contact Dr. Rodney Nairn  (rnairn at mdanderson.org) if you wish to
receive this mail-out information.



7.      POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD; Camden, NJ;
Seattle, WA; Chapel Hill, NC; United Kingdom; Baltimore, MD; Baltimore,
MD; Pittsburgh, PA; Baltimore, MD
 [Note: Check the list for more Job Opportunities on the DNA Repair
Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ ]

7.1 HUMAN DISEASES WITH DEFECTIVE DNA REPAIR - POST DOC POSITION-
BETHESDA, MD

We are studying molecular, cellular and clinical abnormalities in patients
with defective DNA repair and possible links of these genes to disease in
the general population. Current emphasis is on xeroderma pigmentosum,
Cockayne syndrome and trichothiodystrophy.  A postdoctoral position is
available for a talented individual (M.D., Ph.D. or MD-PhD) with less than
5 years of postdoctoral experience who has knowledge of molecular biology
and DNA repair.

To apply, send CV and bibliography and names (with contact information) of
3 references to:
Kenneth H. Kraemer, M.D.
Basic Research Laboratory
National Cancer Institute, NIH
Building 37 Room 3E24
Bethesda,  MD 20892
TEL: 301-496-9033    FAX: 301-496-8419
e-mail: kraemerk at nih.gov
http://rex.nci.nih.gov/RESEARCH/basic/lmc/khk.htm

NIH is an equal opportunity employer

7.2 IMPORTANT SENIOR POSITION SEARCH - PROJECT LEADER - HUMAN GENETIC CELL
REPOSITORY, CAMDEN, NJ

 A cell biologist with broad experience in human genetics and human
genetic diseases with strong administrative skills is sought to serve as
the Principal Investigator on long term contracts for the operation of the
Human Genetic Cell Repository ( http://cimr.umdnj.edu ) sponsored by the
National Institute for General Medical Sciences and the Aging Cell
Repository sponsored by the National Institute on Aging. This leader may
be recruited at the Associate or Full Professor level and will have the
responsibility for managing these cell repositories as components of the
Coriell Cell Repositories, for building these national resources according
to the contract workscopes, and assuring the quality of all parts of the
NIA and NIGMS cell repositories. Ph.D. or M.D. required.

Excellent benefit package. Please send CV and at least three reference
letters to:
Ms. C. Tule
Coriell Institute for Medical Research
403 Haddon Avenue,
Camden, NJ 08103
email: ctule at cimr.umdnj.edu
Fax No. 856 964 0254

AA/EOE/MF

David P. Beck, Ph.D.,President
Coriell Institute for Medical Research
403 Haddon Avenue
Camden, New Jersey 08103
Email: dabeck at umdnj.edu
Voice 856-757-4820
Fax 856-964-0254

7.3 POSTDOCTORAL POSITION IMMUNOGLOBULIN GENE SOMATIC HYPERMUTATION -
SEATTLE, WA

Postdoctoral position available to study the molecular mechanism of
immunoglobulin gene somatic hypermutation. This is a wonderful project for
a postdoctoral fellow who is highly motivated, independent, and creative.
Our laboratory uses the tools of biochemistry, genetics, and cell biology
to study fundamental problems in mammalian DNA repair and recombination.
We are located at the University of Washington, in Seattle, where there is
extensive opportunity for interaction and collaboration with other groups
interested in mutagenesis, recombination, repair, and genomic stability.
The institutional culture encourages and fosters research at the interface
of basic biology and medicine. Seattle is a lively city in an unusually
beautiful setting.

To apply, please send a c.v., a brief statement of research interests
and experience, and names and email addresses of three references to:

Nancy Maizels
Professor, Departments of Immunology and Biochemistry
University of Washington Medical School
Seattle, Washington 98195-7650
phone: 206-221-6876; fax: 206-221-6781
maizels at u.washington.edu



7.4 POSTDOCTORAL POSITION IN DNA DAMAGE CHECKPOINT SIGNALING - Chapel
Hill, NC
Post doctoral fellowship to study the biochemical mechanisms of DNA Damage
Checkpoint Response in human cells and to develop cancer chemotherapeutic
strategies targeting DNA damage checkpoint signaling pathways. Recent
graduates with training in biochemistry, molecular biology, or cellular
biology are encouraged to apply.

Application:
Dr. Aziz Sancar
Department of Biochemistry and Biophysics
Lineberger Comprehensive Cancer Center, CB 7260
University of North Carolina School of Medicine
Chapel Hill, NC 27599-7260
E-mail: Aziz_Sancar at med.unc.edu

7.5 POSTDOCTORAL POSITION IN DNA REPAIR - UNITED KINGDOM

A position is available in the Biochemistry Group to investigate the
biochemical, molecular and cellular processes of DNA repair. Specific
studies include defining the repair mechanism for ionizing
radiation-induced DNA damage with a particular focus on the role of base
excision repair proteins. Position is initially available for 3 years with
possible extension to 5 years. Experience in protein biochemistry an
advantage.

Informal enquiries welcome to Dr. Grigory Dianov.
(g.dianov at har.mrc.ac.uk)

Please send a full CV with the names of two referees, who may be contacted
prior to interview, to Sarah Worrall, Personnel Officer, Medical Research
Council, Harwell, Didcot, Oxfordshire, OX14 0RD, UK, or telephone 44-1235
834393 for further information (please quote ref: RAGSU-04). e-mail:
s.worrall at har.mrc.ac.uk. Closing date: 1st June 2002. Web site:
http://www.har.mrc.ac.uk

7.6 POSTDOCTORAL POSITION - UNIVERSITY OF MARYLAND, BALTIMORE, MD
Position available immediately in the Radiation Oncology Research
Laboratory of the University of Maryland School of Medicine to study the
molecular mechanisms of DNA double-strand break repair. Projects are
focused on the structure and function of the Mre11 complex. We are
coupling modern biochemistry and cell biology approaches with detailed
structural analysis of this protein complex. The postdoc will be expected
to integrate in a concerted effort on a newly funded, highly interactive
project involving multiple laboratories to integrate structure,
biochemistry and cell biology in the study of DNA repair processes.
Please send curriculum vitae and names and addresses of three references
to
James P. Carney, Ph.D.
The Radiation Oncology Research Laboratory
University of Maryland School of Medicine
Bressler Research Building 6-015
655 West Baltimore Street, Baltimore, MD 21201
email: jcarney at som.umaryland.edu.

7.7 POSTDOCTORAL POSITION - MITOCHONDRIAL DNA REPAIR - BALTIMORE, MD

A Postdoctoral position is available immediately to investigate the
molecular and genetic mechanisms of mitochondrial DNA repair and
dysfunction in breast cancer Excellent opportunity for an individual with
experience in mammalian cell culture, DNA transfection, Northern,Southern,
PCR, and general molecular biology techniques.

Experience in mitochondrial methods is desirable but not necessary. Please
forward/fax curriculum vitae and a brief description of research
experience with a list of three references to:

Keshav K. Singh, Ph.D.
Johns Hopkins Oncology Center
Bunting-Blaustein Cancer Research Building
1650 Orleans Street, Room 1-143
Baltimore, Md 21231-1000

Phone: 410-614-5128
Fax:410-502-7234
E-mail: singhke at jhmi.edu

7.8  TENURE-TRACK FACULTY RESEARCH POSITIONS - UNIVERSITY OF PITTSBURGH
CANCER INSTITUTE

The Molecular and Cellular Oncology Program at the University of
Pittsburgh Cancer Institute (UPCI) is undergoing a major phase of
development, and seeks outstanding applicants for several new positions to
be filled over the next year. An advertisement has recently appeared in
Science (see 1 Feb. issue).

We are searching for investigators whose research efforts are directed
toward defining basic molecular mechanisms of the neoplastic process.
Particular areas of interest for these positions include DNA damage repair
and signaling pathways controlling genome stability, cell cycle control
and growth, apoptosis, analysis of tumorigenesis using functional
genomics, chromatin structure, and analysis of cancer-related pathways in
model organisms.

UPCI is an NCI-designated Comprehensive Cancer Center. It is a vigorous
and cooperative environment with programs encompassing basic,
translational, and clinical cancer research which take advantage of the
University and the strong medical center. In July 2002, the Hillman Cancer
Center will open as a new integrated facility and will accommodate the
research activities for these new positions in the Molecular and Cellular
Oncology Program. More information is available on
http://www.upci.upmc.edu/ and http://www.pitt.edu/~rdwood/links2.htm. The
city of Pittsburgh is a most livable city, with continual scientific
growth and a thriving cultural scene.

Recruitment is focused at the Assistant Professor level, although a
position at a more senior level may be available for an individual with an
established research program. Interested applicants should submit a CV
with summary of research accomplishments, a short research proposal and
the names and contact information for 3 referees to:
Dr. Richard D. Wood
University of Pittsburgh Cancer Institute
S867 Scaife Hall Box 100
3550 Terrace Street,
Pittsburgh,PA 15261.

Documents, preferably as a pdf file, can also be sent by email to R.D.
Wood at: smithp4 at msx.upmc.edu.

The positions are open until filled but applications should be submitted
by 15 March 2002 to assure full consideration.


7.9 POST-DOCTORAL SCIENTIST POSITIONS TO STUDY DNA REPAIR MECHANISMS -
BALTIMORE, MD

1.      Post-Doctoral Scientist 1.  Biochemistry of Single-Strand Break
Repair.  This position will entail the characterization and identification
of proteins that function in the repair of common free radical-induced DNA
damages, most notably 3'-obstructive termini (e.g. 3'-phosphate groups).
Studies will involve purification of proteins from bacteria and
baculovirus, detailed biochemical and kinetic analysis, and examination of
protein-protein cooperativity/associations (including defining the
interactive interfaces).  Collaborations with scientists on-site will
permit exploration of the biochemical nature of pathway-pathway
communication.  Experience with molecular biology techniques and protein
biochemistry required.  Position limited to M.D.s and Ph.D.s with less
than 5 years of post-doctoral experience.

2.      Post-Doctoral Scientist 2.  Biology of Base Excision Repair.  This
position will involve studies to monitor the localization patterns of BER
proteins as a function of cell age, cell cycle stage or environmental
exposure.  Studies will also include the evaluation of expressing a
dominant-negative Ape1 protein factor in mammalian cells and/or the
generation of an Ape1 genetic mutant cell line.  Mammalian cell culturing
experience is mandatory, as is a sound understanding of molecular biology
techniques.  Position limited to M.D.s and Ph.D.s with less than 5 years
of post-doctoral experience.

For further details or to apply for one of these positions, please contact
Dr. David M. Wilson III by mail:

Laboratory of Molecular Gerontology, Box 1
National Institute on Aging, IRP, NIH
5600 Nathan Shock Drive
Baltimore, MD 21224-6825

or by email via Pat Freburger at freburgerp at grc.nia.nih.gov.  As part of
the application please include curriculum vitae and three letters of
reference.  NIH is an equal opportunity employer.


8.      ELECTRONIC CONTACTS:
8.1     Check out the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
You can find the schedule for future DNA Repair Interest Group
videoconferences and a listing of past videoconferences (with links to the
videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair
and MEETING NOTICES.

8.2     Encourage your colleagues who are interested in DNA Repair to
request that they be added to this DNA Repair Interest Group listserve
e-mail list by sending a request by e-mail to: listserv at list.nih.gov
Leave the subject  blank. In the message field, type in: subscribe
DNARepair-L your name
        Alternatively, by filling out the form on the website
(http://www.nih.gov:80/sigs/dna-rep/ ) you can both add your name to the
e-mail list and have your name posted on the website.  If you want your
name to be listed you can fill out the "Join the SIG" form on the web site
and add your name to the listing of members.  If you are not at NIH then
be sure to click the "other" box and then fill in the name of your
institution.

8.3     Archives of these listserve mailings can be found at
        http://list.nih.gov/archives/dnarepair-l.html  or via links from
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/

8.4     I will be happy to relay information about post-doctoral
positions, jobs and meetings and other information related to DNA Repair.
Please send me an e-mail message (kraemerk at nih.gov) and I will incorporate
it into the next announcement list and post it on the DNA Repair Interest
Group web site: http://www.nih.gov:80/sigs/dna-rep/ .
(This list goes to nearly 850 scientists around the world who are
interested in DNA repair.)


Kenneth H. Kraemer, M.D.
Chief, DNA Repair Section
Basic Research Laboratory
National Cancer Institute
Building 37 Room 3E24
Bethesda,  MD 20892
301-496-9033    FAX: 301-496-8419
e-mail: kraemerk at nih.gov
DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/


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