[Toxicology] WG: Question about Alkaloids...

jens prager via toxicol%40net.bio.net (by unimoc from yahoo.de)
Wed Jun 1 07:15:06 EST 2011



--- jens prager <unimoc from yahoo.de> schrieb am Mi, 1.6.2011:

Von: jens prager <unimoc from yahoo.de>
Betreff: Question about Alkaloids...
An: neur-sci from net.bio.net
Datum: Mittwoch, 1. Juni, 2011 14:09 Uhr

Hi, 
durig doing some research in the internet I met your side (http://www.bio.net. ...)
My name is Jens and I am a student of Georgaphy and Archaeology and I am writing about Ergotism in France and Germany...
In Germany you only had convulsive ergotism (which could be a hind that alkaloids passed the Blood-Brain-Barrier, autopsies showed degeneration of the spinal cord and cretinism) and in France gangrene ergotism.
My question: When alkaloids pass the blood-brain-barrier, why do we have no reports about convulsive ergotism in France and no reports about cretinism? Is it possible that blood-brain -barrier is less permeable to special alkaloids? Which influence has diet on that (in Germany and Denmark ergotism was cured with feeding eggs and ham...)

With greetings,
Jens


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