receptors and transcytosis

MFREIS at NOMVS.LSUMC.EDU MFREIS at NOMVS.LSUMC.EDU
Sat Aug 7 16:28:00 EST 1993


This is in response to David Coates question about whether animal
viruses can transcytose.  There is a new model for
how enteric viruses (Poliovirus and reovirus, so far)
cross the gut barrier.  A (relatively) newly identified cell type,
called "M" cells may nonspecifically transcytose the contents of
the gut lumen into the underlying lymph tissue.  The
evidence that this occurs in a natural infection is,
so far, indirect.  For technical reasons, it still is not
known whether the poliovirus receptor is expressed at the lumenal
face of the intestinal mucosa.  The reovirus receptor
has not been identified.  The "M" cells (from biopsies)
This is in response to David Coates'question about whether animalcan transcytose poliovirus in culture.




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