HepC

brett at BORCIM.WUSTL.EDU brett at BORCIM.WUSTL.EDU
Thu Jul 8 15:38:10 EST 1993


Sorry to hear about your relative. I am not an MD, but am researching HCV as a
grad student. BTW, I AM VERY INTERESTED IN HEARING FROM OTHER HCV WORKERS.
HCV is often acute (that is, the infection is resolved). However, frequently
a chronic condition ensues, in which there is a persistence of HCV. There is
a correlation between chronic HepC and hepatocellular carcinoma - not a very
positive outlook for these patients. About 1/2 HCV+ individuals will go chronic
and ~2/3 of chronic patients are at risk for HCC, while ~1/5 of chronic patients
may develop cirrhosis. (ARCH.VIR.(1991); vol 120: 165-180). Generally, HCV is
a recently identified hepatitis agent mainly spread by blood transfusion. The
virus is similar to pestiviruses and flaviviruses (whose members include the
infamous yellow fever virus). I am mainly interested in the immune response
to this virus for any and all interested. Hope this helps,

Brett Lindenbach
Program in Immunology
Division of Biology and Biomedical Sciences
Washington University in St. Louis

brett at borcim.wustl.edu




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