IMMUNOFAN - new high effective immunostimulant

Igor M. Maltcev root at amtis.kaluga.su
Tue Jul 5 08:26:31 EST 1994


  EXPERIMENTAL AND CLINICAL TRIAL OF IMMUNOFAN  (RUSSIA  1989-94)
                             (Abstract)
  For Review see:
  group sci.med, art 63891

  IMMUNOFAN is a preparation, containing synthetic hexapeptide as
an acting substance. Molecular mass 836 D.
  IMMUNOFAN highly increase the immune response to viral, bacterial
or artificial antigens, show the powerful buster effect in
combination with vaccines.
  IMMUNOFAN is used with preventive and curative aims for restoration
of cell-mediated and humoral immunity in congenital and acquired
immune deficiency of various etiology.
  IMMUNOFAN has an exceptional low toxicity and provides the wide
safety reserve.  The single dose as higher as 1000 middle therapeutic
dose does not cause deaths in the experimental animals.
  The IMMUNOFAN administration does not cause local irritating
effect, allergic reactions and mutagenesis.
  IMMUNOFAN is intended for treatment of immunodeficiency states of
various ethiology and diseases with concurrent immunity disturbances.
The drug has immunoregulating, antiinflammatory, disintoxicating,
hepatoprotective and radioprotective action.
  IMMUNOFAN may be recommended for adults as a drug for prophylaxis
and treatment of the chronic viral and bacterial infections including
chronic active and persisting viral hepatitis B, HIV infection,
brucellosis, yersiniosis and for producing of booster effect after
vaccination.
  IMMUNOFAN is used with preventive and curative aims for restoration
of cell-mediated and humoral immunity in congenital and acquired
immune deficiency of various etiology.
  Experience with administration of IMMUNOFAN for prevention and
treatment diseases in farm animals (young cattle, pigs, male, cows
etc.); poultry, pet animals (dogs, cats) shows its high effectiveness
to prevent complications caused by immunization, to induce potent
post vaccinate immunity and increase animal resistance to infection,
to prevent hyponutrition in fetus and newborns, to increase survival
and viability in offspring, to synchronize sexual cycle, to increase
fertility, to decrease spontaneous abortion and still birth rate, to
help with favorable course of gestation.
  In experimental/biotechnological warmblooded animals IMMUNOFAN
useful for stimulation of booster effect during immunization to
increase titters of specific antibodies.
  The close analog of IMMUNOFAN is Thymopentin (Thymunox), produced
on the base of synthetic pentapeptid by the firm Cilag AG
International (Switzerland).  The main advantage of the IMMUNOFAN is
its ability to stimulate markedly antiviral immunity. The recommended
single dose of IMMUNOFAN is 1-1,5 mcg/kg of the body mass, but that
of Thymopentin (Thymunox) is about 700 mcg/kg.
  IMMUNOFAN produced as 0.005% sterile solution in isotonic sodium
chloride, pH 6.4 - 6.6, for subcutaneous or intermuscular injections
in glass ampules of 1.0 ml, 10 ampules/box.

         From: mr. Vladimir Bolibok,
      Head of Clinical Immunology Laboratory,
      Consultative physician-immunologist,
      City Hospital No 5 of Kaluga,
      phone +7(084)-2249648  (Russian or English)
         E-mail: root at amtis.kaluga.su





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