Help with herpes viruses

Zafer Yildirim zxy5 at po.CWRU.Edu
Wed Oct 26 01:01:23 EST 1994


I know that , for example , vaccinia viruses have been used in 
transfer of foreign genes into cells. The gene is incorporated
into the viral genome by homologous recombination from a plasmid
if I am not wrong. Has anybody tried this or any other method to 
incorporate genes into the herpes virus genome ? Which part of 
the viral genome is targeted in general ? How stable would it 
be (I mean the recombinant virus) ? What promoters for expression
of the foreign gene would be used ? How can we select for the 
recombinant virus? ...

Thanks in advance.




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