Idea for Ebola Vaccine
wilson at cs.utexas.edu
Wed Aug 2 18:50:48 EST 1995
In article <3v5ual$egh at cisunix1.dfci.harvard.edu>,
Ian A. York <york at mbcrr.dfci.harvard.edu> wrote:
>In article <3v40i0$o2b at grape.epix.net> Dave Peters <dpeters> writes:
>>I've been wondering....
>>Could the Reston form of Ebola somehow be the key to a vaccine for the
>>deadly Ebola Zaire virus?
>It's not a completely wild idea, but it's unlikely to work. We had a
>disucssion about this some time ago.
> [...] that there is some suggestion that Ebola (like Dengue)
>has antibody-mediated enhancement of infection and so Reston accination
>might actually make things worse. Again, without a good experimental
>system thsi is all guesswork; and the risks of a bad guess are terrible.
What about a massive dose of dead viruses? Is there a good reason killed
viruses wouldn't cause the appropriate antibody generation, without actually
infecting somebody with an immuno-threatening disease?
(Ob warning: I'm no virologist.)
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