Intravirion nucleic acid replication

Karl Fischer kfischer at
Sat Aug 26 06:14:55 EST 1995

The virus we work with (hepatitis B virus) encapsidates a pregenomic RNA
which is reverse transcribed WITHIN the virus capsid to give the partially
double-stranded DNA genome.

My question is - What other viruses demonstrate intravirion replication of
their genome as opposed to ex virion synthesis then encapsidation?

I suspect caulimovirus (another pararetrovirus) does this but am curious
as to what other viruses utilize this strategy.



Karl Fischer
tyr-2 at
kfischer at

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