Was - RNA pol, replication fidelity

Karl Fischer tyr-2 at bones.biochem.ualberta.ca
Sat Dec 2 18:32:07 EST 1995


In article <hbClj14.brunker at delphi.com>, Marla Brunker
<brunker at delphi.com> wrote:

> Scott A Hoffman <schoffma at badlands.nodak.edu> writes:
>  
> >RNA viruses (most notably Ebola and Dengue) show a high replication 
> >fidelity.
 
<snip>

>         This isn't any kind of answer to your question but...if the
> reverse transcriptase from these viruses is more efficient than what's
> available commercially (my Boehringer-Mannheim catalogue lists two, one
> from avian myeloblastosis virus and a recombinant MMuLV RT)
> would it be worth the bother of figuring out how to produce this
> recombinantly?

Sorry Marla - these viruses do NOT have reverse transcriptases; they do
not replicate through a DNA intermediate.

Karl

-- 
Karl Fischer
tyr-2 at bones.biochem.ualberta.ca





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