Idea for Ebola Vaccine
Ian A. York
york at mbcrr.dfci.harvard.edu
Wed Jul 26 12:34:13 EST 1995
In article <3v40i0$o2b at grape.epix.net> Dave Peters <dpeters> writes:
>I've been wondering....
>Could the Reston form of Ebola somehow be the key to a vaccine for the
>deadly Ebola Zaire virus? Edward Jenner used the cowpox virus to make a
>vaccine for the similar smallpox virus. Could the Reston form of Ebola
>that does not affect humans somehow be used to vaccinate people against
>Ebola Zaire? Please post your comments.
It's not a completely wild idea, but it's unlikely to work. We had a
disucssion about this some time ago. To summarize that argument, there
is no guarantee that it will work, and because of the problems in finding
a valid experimental system, it's not testable yet. I also remember
reading somewhere (sorry, my mind is melting in the heat and I can't
remember where) that there is some suggestion that Ebola (like Dengue)
has antibody-mediated enhancement of infection and so Reston accination
might actually make things worse. Again, without a good experimental
system thsi is all guesswork; and the risks of a bad guess are terrible.
Ian York (york at mbcrr.harvard.edu)
Dana-Farber Cancer Institute, 44 Binney St., Boston MA 02115
Phone (617)-632-3921 Fax (617)-632-2627
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