The genetic stability of Ebola virus
c601591 at mizzou1.missouri.edu
Sat Jul 29 14:50:14 EST 1995
In article <evans-2807951508000001 at ganymede.ahabs.wisc.edu>,
evans at ahabs.wisc.edu (PSE) wrote:
> Does it surprise anybody that an RNA virus that has been replicating in
> the wild for almost 20 years has accumulated very few variations at the
> nucleic acid level? Sanchez et al do not comment about the resulting
> proteins, so many or all of these mutations may have been silent.
> Is this the kind of variation that would be expected from an RNA virus
> over such a time period due to genetic drift (ie: neutral evolution")?
> Is there any data about genetic drift in filoviruses, or other RNA
Given the replication strategy of filoviruses which is fairly simple (see
Feldman et al.) I am not surprised. All of this data might imply that the
filovirus RNA dependant RNA Pol. is a very accurate Pol. I think these
are really interesting questions and it will be fun to see what the answer
> Does the lack of genetic changes imply anything about Ebola's natural
Possibly. As Sanchez suggested, there may be extreme selective pressure
to maintain the Ebola Genome as it is.
Molecular Microbiology and Immunology
University of Missouri-Columbia
C601591 at showme.missouri.edu
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