HIV sequence from virus

Donald A. Lehn, Ph.D. dalehn at facstaff.wisc.edu
Thu Jun 8 11:17:33 EST 1995


In article <3r5lph$759 at miasun.med.miami.edu>, 
tmiller at newssun.med.miami.edu says...
>

>PS--Don, did you figure out why I wanted to know now?

But the variability of HIV comes mainly from the RNA -> DNA step.
It is caused by the rather poor fidelity of reverse transcriptase.
At this point there is only ONE virus.  What you are looking at
is the DNA -> RNA step, the step that produces the millions of
viral particles.  The RNA polymerase used in this step, that from
the host, has a very high fidelity.  Therefore, the virus particles
produced will be identicle to the provirus that it came from.

Don

-- 
Donald A. Lehn, Ph.D.                   Phone:  (608) 263-7668
Medical Sciences Center / 3415          Fax:    (608) 262-9300
University of Wisconsin Medical School  Email:  dalehn at facstaff.wisc.edu
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