HIV sequence from virus
Donald A. Lehn, Ph.D.
dalehn at facstaff.wisc.edu
Thu Jun 8 11:17:33 EST 1995
In article <3r5lph$759 at miasun.med.miami.edu>,
tmiller at newssun.med.miami.edu says...
>PS--Don, did you figure out why I wanted to know now?
But the variability of HIV comes mainly from the RNA -> DNA step.
It is caused by the rather poor fidelity of reverse transcriptase.
At this point there is only ONE virus. What you are looking at
is the DNA -> RNA step, the step that produces the millions of
viral particles. The RNA polymerase used in this step, that from
the host, has a very high fidelity. Therefore, the virus particles
produced will be identicle to the provirus that it came from.
Donald A. Lehn, Ph.D. Phone: (608) 263-7668
Medical Sciences Center / 3415 Fax: (608) 262-9300
University of Wisconsin Medical School Email: dalehn at facstaff.wisc.edu
1300 University Avenue Home: (608) 277-1025
Madison, WI 53706-1532
Diabetes Knowledgebase: http://www.biostat.wisc.edu/diaknow/index.htm
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