antigen presentation and enhancing antibody
brett at BORCIM.WUSTL.EDU
Thu Nov 2 04:39:34 EST 1995
>As far as antibody-mediated enhancement of infection, it's only seen in a
>relative handful of viruses, of HIV may (or may not, in vivo) be one. The
>classic example is dengue virus. The two basic requirements (fairly
>obvious, really) are that the antibodies be non-neutralizing and the virus
>be able to survive in an Fc-bearing cell. Here are a couple of papers you
>might find useful -
> Kurane I. Rothman AL. Livingston PG. Green S. Gagnon SJ. Janus J.
>Innis BL. Nimmannitya S. Nisalak A. Ennis FA.
> Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock
> Archives of Virology - Supplementum. 9:59-64, 1994.
> Jiang SB. Lin K. Neurath AR.
> Enhancement of human immunodeficiency virus type 1 infection by
>antisera to peptides from the envelope glycoproteins gp120/gp41
>Journal of Experimental Medicine. 174(6):1557-63, 1991
Well, not quite right. For flaviviruses, the Ab need not be "non-neutralizing",
it must just be at a subneutralizing concentration. In vitro, most any anti-E
Ab can be used, at the right dilution. In vivo, this may mean that low levels
of Ab from a primary infection may be important in enhancing a secondary
infection early on.
Program in Immunology
Washington University - St Louis
brett at borcim.wustl.edu
"I own my own pet virus. I get to pet and name her." - Cobain
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