antigen presentation and enhancing antibody

David Beasley d.beasley at
Fri Nov 3 00:42:03 EST 1995

In article <478ad1$bnj at>, iayork at (Ian A. York) says:


>As far as antibody-mediated enhancement of infection, it's only seen in a
>relative handful of viruses, of HIV may (or may not, in vivo) be one.  The
>classic example is dengue virus.  The two basic requirements (fairly
>obvious, really) are that the antibodies be non-neutralizing and the virus
>be able to survive in an Fc-bearing cell.  Here are a couple of papers you
>might find useful -
> Kurane I.  Rothman AL.  Livingston PG.  Green S.  Gagnon SJ.  Janus J. 
>Innis BL.  Nimmannitya S.  Nisalak A.  Ennis FA. 
> Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock
> Archives of Virology - Supplementum.  9:59-64, 1994.
> Jiang SB.  Lin K.  Neurath AR.
> Enhancement of human immunodeficiency virus type 1 infection by 
>antisera to peptides from the envelope glycoproteins gp120/gp41
>Journal of Experimental Medicine.  174(6):1557-63, 1991

Some neutralising antibodies have been shown to enhance in vitro dengue
virus infection of cells when present at low concentrations.  

As far as I know, antibody-dependent enhancement of dengue infection has
still only be demonstrated as an in vitro phenomenon.  ADE is a nice
theory for the development of dengue haemorrhagic fever, but still doesn't
explain why only 2-3% of anamnestic infections result in the more severe
form of disease.  The whole concept of ADE seems to be fairly contentious
amongst flavivirus (and particularly dengue) researchers.

David B.

David Beasley                              
School of Life Science                      
Queensland University of Technology        
GPO Box 2434                                 
Email: d.beasley at

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