BIE034 at news.salford.ac.uk wrote:
>> I was recently reading a book on protein structure and was intrigued by the
> influenza haemaglutinin protein. The book remarked that on the lowering
> of the pH whilst inside the endocytotic vesicle the viral protein undergoes a
> considerable structural change to fuse the viral membrane to that of the
> vesicle. The book was several years old but I would assume that such a change
> would be an ideal target for drug interactions and so should have a large
> body of associated research. Could anyone tell me if there has been any
> progress in determining the mechanism by which the change occurs? If so I
> would appreciate any pertinent references which they may know!
>> I thank everyone for their help
> Simon.
Simon,
Another useful review regarding the influenza HA protein would be:
Gaudin, Y. et al, Low pH induced conformational changes in viral
fusion proteins: implications for the fusion mechanism, J. Gen.
Virology, 1995, 1541-1556.
Henry Putz
Dept. of Virology
Bristol-Myers Squibb
