spongiform encephalopathy in young humans
MATTHEW FRANCIS WETTLAUFER
mattw at sfsu.edu
Thu Nov 23 13:27:37 EST 1995
: But the way you said it, might get some non-scientific people to assume
: that scientists believe in the BSE / CJD connection. Coming from Germany
: I know what this can lead to in the general public. Therefore I might
: have been requesting too much precision.
I think you were asking for the precision that most people would expect
in scientific discourse, and which I failed to give in my very first
entry to this group.
: > As far as I can see you haven't made any
: > serious argument in response to my comments about a possible connection
: > between BSE and the two recent cases of CJD in the U.K. Most scientists
: > familiar with prion etiology would not find issue with the comments I
: > made.
: Indeed, I am not much.
I imagine you are more familiar than I on this subject and my comment was
little more than a cheap shot..
: Not bizarre, but premature. That all I wanted to say. Probably I overshot
: with the scrapie stuff quite far.
Probably not--your request for caution was appropriate.
: As far as I understood, crossing the species barrier (generally) required
: higher doses. But it is not the way, that by crossing one species barrier,
: the next will be crossed more easier. Mouse PrP<sc> can cause hamster PrP<sc>,
: but the latter have it as difficult to go back to mouse as it was before
: to get transmission to the hamster. (Please correct if wrong. This is just
: a statement, not a try to blame again).
Again, you are correct--prions do not make species leaps in every
case--only in some, not others. The suggestion that prions are more
likely to make further species leaps after making one was not mine, it
was someone else's. I am not familiar that information--which isn't to
say it's not true, I'm just not familiar with it.
: It concerns me, but I do not think that this is a proof. I am glad the
: Germans (and probably other contries) stopped to import UK cattle.
I'm glad too! And my comment that you aren't concerned again, was a
: Up to now, the discussion will apparently not lead anywhere. As was
: pointed out before, any information on these two cases might give some more
: reasonable starting point and might lead to some discussion based on
: stronger data.
I agree--I wrote to Dr. Stanley Prusiner at UCSF asking him some
questions regarding the two CJD cases in London, and I am awaiting his
response. He may in fact be too busy to reply But if he does I will post
any information he gives me.
Again, my apologies for that previous posting. I look forward to
continuation of this discussion as more information becomes available
and I wish you the best.
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