Intravirion nucleic acid replication
enkemans at dc37a.nci.nih.gov
Sat Sep 2 16:30:10 EST 1995
In article <kfischer-2608951214550001 at duckter.glaxo.med.ualberta.ca>,
kfischer at gpu.srv.ualberta.ca (Karl Fischer) wrote:
> The virus we work with (hepatitis B virus) encapsidates a pregenomic RNA
> which is reverse transcribed WITHIN the virus capsid to give the partially
> double-stranded DNA genome.
> My question is - What other viruses demonstrate intravirion replication of
> their genome as opposed to ex virion synthesis then encapsidation?
> I suspect caulimovirus (another pararetrovirus) does this but am curious
> as to what other viruses utilize this strategy.
> Karl Fischer
> tyr-2 at bones.biochem.ualberta.ca
> kfischer at gpu.srv.ualberta.ca
Some of the double stranded RNA viruses replicate their genomes from
within the capsid. The polymerase molecule is actually part of the
capsid. For a minireview check out JBC vol. 268 page 3797.
Steven A. Enkemann PhD.
I don't believe that curiosity killed the cat.
I think it just did the wrong experiment.
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