Viral DNA insertion into host genome.

Don Haut c601591 at mizzou1.missouri.edu
Tue Sep 12 16:14:33 EST 1995


In article <Pine.A32.3.91.950909123618.24020C-100000 at red.weeg.uiowa.edu>,
volm timothy gerard <tvolm at blue.weeg.uiowa.edu> wrote:

> Hello,
> 
>          Was curious to know whether or not viral DNA intergration into 
> the host genome was site specific, or sequence dependant. Was just 
> thinking that this would make sense since non specific insertion into the 
> host genome might prove fatal for the host. Anyone have any information 
> on this?   Thanks, Tim Volm

I know that AAV integration into human chromosome 19 (I think) is site
specific.  It is dependant on the terminal invered repeats which all
parvoviruses have at both ends.  AAV is the only parvovirus known to
integrate.

Don

Don Haut 
Molecular Microbiology and Immunology
University of Missouri-Columbia
C601591 at showme.missouri.edu
314-882-3171



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