harwoods at AVA.BCC.ORST.EDU
Fri Sep 15 13:25:53 EST 1995
On 14 Sep 1995, Shigeru Morikawa wrote:
> Does anyone know any paper describing that the baculovirus
> does NOT infect other insect or/and mammamlian cells.
> Thank you in advance.
One of the most complete references is the following book chapter:
Specificity and Safety of Baculoviruses. Groner, A. in "The Biology of
Baculoviruses" (Granados, R.R. and Federici, B.A., eds) Volume 1 pg.
178-202 1986 CRC Press > >
Reading of this chapter and consultation of the references provided
should give you a good feel for baculovirus safety issues.
The bottom line is that wt baculoviruses infect only a limited subset of
arthropods (species dependent) and have low toxicity to mammals, fish,
birds, reptiles, etc. Baculoviruses can enter mammalian cells but
do not replicate.
Dept. Agricultural Chemistry
Oregon State University
Corvallis, OR 97331
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