"Ebola Reston"???

a rose andreas.rose at biologie.uni-regensburg.de
Mon Apr 22 19:13:07 EST 1996

Greetings again,

And thanks to everybody who answered so far. Below is a PM I received from John W. 
Huggins. I found it interesting for the rest of you as well (he gives references) and he 
allowed me to post it. The paragraph is part of a book chapter he is writing for 
Clinical Virology (Livingston Press) and that should be out this fall. He sais all the 
information cited is already published.

(----begin quote----)

Marburg and Ebola viruses have genomes of negative sense RNA and share many
unique properties including a distinctive filamentous morphology, placing
them in the family Filoviridae within the order Mononegavirales.
        Marburg virus has no know subtypes, while Ebola virus has at least
four subtypes (Zaire[1] , Sudan[1] , Ivory Coast[2]  and Reston[3] ).
There is no antigenic cross-reactivity between Marburg and Ebola viruses,
but the subtypes of Ebola virus have common as well as unique epitopes.
The nucleotide sequence difference between Ebola subtypes is 47% compared
to 72% between Marburg and Ebola-Zaire [4, 5] .  Peptide and
oligonucleotide mapping provided initial evidence for the distinction
between the Zaire and Sudan subtypes of Ebola virus [1, 6] .
1.      Buchmeier MJ, DeFries RU, McCormick JB, Kiley MP. Comparative
analysis of the structural polypeptides of Ebola viruses from Sudan and
Zaire. J.INFECT.DIS. 1983;147:276-281
2.      Le Guenno B, Formentry P, Wyers M, Gounon P, Walker F, Boesch C.
Isolation and partial characterisation of a new strain of Ebola virus [see
comments]. Lancet 1995;345:1271-4
3.      Jahrling PB, Geisbert TW, Dalgard DW, Johnson ED, Ksiazek TG, Hall
WC, Peters CJ. Preliminary report: isolation of Ebola virus from monkeys
imported to USA. LANCET 1990;335:502-505
4.      Sanchez A, Kiley MP, Holloway BP, Auperin DD. Sequence analysis of
the Ebola virus genome: organization, genetic elements, and comparison with
the genome of Marburg virus. Virus Res 1993;29:215-240
5.      Feldmann H, Klenk H-D, Sanchez A. Molecular biology and evolution
of filoviruses. Arch Virol 1993;7(suppl):81-100
6.      Cox NJ, McCormick JB, Johnson KM, Kiley MP. Evidence for two
subtypes of Ebola virus based on oligonucleotide mapping of RNA.
J.INFECT.DIS. 1983;147:272-275

John W. Huggins

(----end quote----)

Thanks again and best wishes,


Andreas M. Rose, Dipl. Biol.
Zoologie * Universitaet Regensburg * D-93040 Regensburg * Germany * EU
phone: +49-941-943-3076 * fax: +49-941-943-3052

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