andreas.rose at biologie.uni-regensburg.de
Mon Apr 22 19:13:07 EST 1996
And thanks to everybody who answered so far. Below is a PM I received from John W.
Huggins. I found it interesting for the rest of you as well (he gives references) and he
allowed me to post it. The paragraph is part of a book chapter he is writing for
Clinical Virology (Livingston Press) and that should be out this fall. He sais all the
information cited is already published.
Marburg and Ebola viruses have genomes of negative sense RNA and share many
unique properties including a distinctive filamentous morphology, placing
them in the family Filoviridae within the order Mononegavirales.
Marburg virus has no know subtypes, while Ebola virus has at least
four subtypes (Zaire , Sudan , Ivory Coast and Reston ).
There is no antigenic cross-reactivity between Marburg and Ebola viruses,
but the subtypes of Ebola virus have common as well as unique epitopes.
The nucleotide sequence difference between Ebola subtypes is 47% compared
to 72% between Marburg and Ebola-Zaire [4, 5] . Peptide and
oligonucleotide mapping provided initial evidence for the distinction
between the Zaire and Sudan subtypes of Ebola virus [1, 6] .
1. Buchmeier MJ, DeFries RU, McCormick JB, Kiley MP. Comparative
analysis of the structural polypeptides of Ebola viruses from Sudan and
Zaire. J.INFECT.DIS. 1983;147:276-281
2. Le Guenno B, Formentry P, Wyers M, Gounon P, Walker F, Boesch C.
Isolation and partial characterisation of a new strain of Ebola virus [see
comments]. Lancet 1995;345:1271-4
3. Jahrling PB, Geisbert TW, Dalgard DW, Johnson ED, Ksiazek TG, Hall
WC, Peters CJ. Preliminary report: isolation of Ebola virus from monkeys
imported to USA. LANCET 1990;335:502-505
4. Sanchez A, Kiley MP, Holloway BP, Auperin DD. Sequence analysis of
the Ebola virus genome: organization, genetic elements, and comparison with
the genome of Marburg virus. Virus Res 1993;29:215-240
5. Feldmann H, Klenk H-D, Sanchez A. Molecular biology and evolution
of filoviruses. Arch Virol 1993;7(suppl):81-100
6. Cox NJ, McCormick JB, Johnson KM, Kiley MP. Evidence for two
subtypes of Ebola virus based on oligonucleotide mapping of RNA.
John W. Huggins
Thanks again and best wishes,
Andreas M. Rose, Dipl. Biol.
Zoologie * Universitaet Regensburg * D-93040 Regensburg * Germany * EU
phone: +49-941-943-3076 * fax: +49-941-943-3052
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