Ebola Virus Question
MATTHEW FRANCIS WETTLAUFER
mattw at sfsu.edu
Tue Jan 2 12:57:23 EST 1996
EdRegis (edregis at aol.com) wrote:
: >I am sure someone has thought of this before... but why couldn't
: >Ebola Reston be used as a vaccine for Ebola Zaire and Sudan?
: Probably because of the lack of homology and cross-reactivity among the
: three. Ebo-R was not fatal to humans although it was for cyno monkeys.
: Ebo-Zaire-Kikwit convalescent serum was used in the Kikwit outbreak when
: Tamfum Muyembe injected 8 Ebola patients in Kikwit General Hospital with
: serum taken from previous survivors of that outbreak, which had a 77%
: fatality rate. Seven of those eight survived, although some critics have
: made the point that maybe those patients were getting better anyway.
: edregis at aol.com
Also, from my understanding of the three strains, they are serologically
related but genotypically distinct so that challenge with a wild-strain of
Ebola Zaire or Ebola Sudan, following vaccination with Reston, might not
induce neutralizing antibodies but rather antibodies that would facilitate
uptake of the virus via Fc-receptors on macrophages, greatly increasing
the disease, as happened with the dengue vaccine. Isn't this part of the
fear surrounding some of the clade vaccine research for HIV?
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