Hepatitis C virus antibody specificities?

Alun Kirby akirby at eastman.ucl.ac.uk
Mon Jun 3 06:00:37 EST 1996


Biogenesis market several different monoclonals directed against HCV 
core protein amino acid sequence 1-120. These are clones 215/057 and 
0126. A recent paper by Gonzalez-Peralta, Fang.....and Lau (J Hepatol 
1994; 20: 143-147) said that best immunohistochemical results were 
obtained using mAbs directed against core protein aa26-45.
So, does anybody know precisely which sequence Biogenesis mAbs are 
against, as they have been unable to help, or can someone recommend a 
mAb known to be suitable for immunochemistry?

Finally, if all else fails, does anybody know any of the authors of 
the HCV mAb paper mentioned. They are based at the University of 
Florida, Gainsville, USA.

Many thanks.

Alun Kirby and Giovanni Lodi



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