>>To:Brian Foley <btf at t10.lanl.gov>
>From:mfreis at lsumc.edu (marion freistadt)
>Subject:Re: Ebola passive immunization
>>Re: Ebola passive immunization.
>>There was an article in my local newspaper that passive immunization of Ebola
>infected patients worked in a few cases. It may be real; however, these were
>not controlled studies and it is not clear if the patients would have
>>The reason this cannot be done for HIV infection (aside from all the
>practical, financial, and political problems) is because unlike Ebola, the
>natural immune response to HIV is not protective. (I know there are a few
>exceptions, but this, IMHO, is the central problem.)
>>>>>>Ian Nies wrote:
>>>>>> Has anyone heard about the doctor in Zaire who injected
>>> a nurse that became
>>> infected with ebola virus, with the blood of a patient
>>> who survived ebola
>>> infection? The story is that the nurse having been
>>> injected with patient's
>>> blood recovered and survived ebola infection as a result .
>>>>>> Sent on behalf of P. Nino, curious patient with AIDS.
>>>> I have not heard that story. However, it is possible.
>>Many diseases can be fought with such methods. The patient
>>who survived the Ebola infection would have a high level of
>>antibodies against Ebola. Thus a pint of blood from this
>>patient may have enough antibodies to fight the infection in
>>the nurse. In order to give a pint of whole blood, the donor
>>and nurse would have to be of compatible blood types. I
>>believe there is a method of purifying antibodies, so that
>>just the antibody fraction of blood is used, instead of whole
>>blood. If I remember correctly, there have even been antibodies
>>raised in horses, which are used to fight Diphtheria in humans.
>> However, not all diseases can be fought with such
>>methods. Ebola virus causes a rapid/acute disease and HIV
>>does not. There was a study:
>>>>F.Bex, P.Hermans, S.Sprecher, A.Achour, R.Badjou, C.Desgranges,
>> J.Cogniaux, P.Franchioli, C.Vanhulle, and A.Lachgar.
>>Syngeneic adoptive transfer of anti-human immunodeficiency virus
>> (HIV-1)-primed lymphocytes from a vaccinated HIV-seronegative
>> individual to his HIV-1-infected identical twin.
>>Blood 8484:3317--3326, 1994.
>>>> In which one of a pair of identical twins was vaccinated
>>against HIV, with the hope of saving the other twin from
>>HIV infection. I think the long-term result was not successful,
>>but I am not sure.
>>|Brian T. Foley btf at t10.lanl.gov |
>>|HIV Database (505) 665-1970 |
>>|Los Alamos National Lab http://hiv-web.lanl.gov/index.html |
>>|Los Alamos, NM 87544 U.S.A. http://hiv-web.lanl.gov/~btf/home.html|>>|____________________________________________________________________|