Mechanisms of Chronic Infections
robin at louis.bidmc.harvard.edu
Sat Feb 8 06:13:31 EST 1997
I need to get thoughts and references together to write at length but
right off let me just compare a few human viruses and mention some
other chronic infections:
The classic chronic-latent infections, HSV, Varicella, CMV
which manage to set up a semi-dormant state in longlived
cells with expression of only a limited subset of latency genes.
Now with Human Herpesviruses 1-8 (!) there are interesting
similarities and differences between them (e.g KSHSV)
HIV, SIV, HTLV, etc. which maintain both latent infection
and persistent active infection.
3) Hepatitis B
A "retroposon" without a proviral form also with latent,
persistent and chronic active forms.
To my knowledge the only chronic human RNA virus infection.
How it does this has long been an interesting mystery to me.
Warts, cervical ca
Papovaviral cause (?) of PML in AIDS
7) Others? Veterinary examples?
Also, compare with mechanisms of non-viral persistence:
protected sites: prostate, sinus
persistent intracellular infection: chlamydia, malaria, leishmania
relapsing latent infection: TB, leprosy, syphillus, lyme oddballs:
and a zillion more.
Obviously this is way too big a topic for one post but if people will
do little pieces within their specialties, we could run this out
pretty far. I could do Hep B or HIV. Any takers?
Division of Infectious Diseases
Beth Israel Deaconess Medical Center
Harvard School of Medicine
More information about the Virology