influenza A infectivity

Paul pd1 at mole.bio.cam.ac.uk
Thu Oct 19 08:32:31 EST 2000



Ruth B Hamilton wrote:

> Most papers I have read on the growth of influenza A (in culture) measure
> virus yield in PFU/ml (or similar units).
> I would like to relate this to absolute numbers but have not been able to find
> any information on (roughly) how many virus particles = 1 PFU. Can anyone
> help?
>
> ruth
>
> ---

The figures we tell our undergraduate students were worked out
a number of years ago for an avian (A/FPV) strain of flu and come
out at:

1 HAU ~ 10E7 particles ~ 10E6 egg infectious doses ~ 10E5 pfu

I think this is probably ball-park correct for most strains of flu, but
it will vary.  Growth conditions, storage etc. will also affect things.

Hope this helps

Paul Digard

Division of Virology
Department of Pathology
University of Cambridge



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