Strain / variant

A.J.Cann nna at
Mon Mar 5 12:14:06 EST 2001

In article <MLJn6.911$o4.45261 at>, jason roberts
<pteropid1 at> wrote:


> For example take nvCJD, is it ever referred to a different strain of CJD...

Yes, the concept of "strain variation" has been important in prions. 
The existence of many different strains of scrapie (at least 15,
defined by latency, lesion patterns differ) which can be propagated in
the same inbred mouse strain. These can transmit serially without
changes in properties in the same mouse strain homozygous for a single
PrP genotype.  However, I'm not sure this helps with the original

Dr Alan J. Cann  PhD,   Department of Microbiology & Immunology,
University of Leicester,  P.O. Box 138,  Medical Sciences Building,
University Road, Leicester LE1 9HN,  UK.


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