virus entry into mammalian cells...

Roland Hübner rhubner at hgins.uia.ac.be
Thu Mar 29 04:40:57 EST 2001


Hello,

 I was quite surprised to receive the following reply by email (I asked 
a question about selection of a virus for the purpose of gene therapy)

>most viruses produce a high percentage (>95%) of defective particles 
>and a low percentage of wild type particles (<5%)

 So far, I knew that polyomaviruses were described to produce defectives 
(DNA level) after entry into cells (nucleus), but from this reply it 
sounds that this is rather a general property... (!?)

 Is this view OK? Would it hold for RNA, ss, ... viruses too? 
Independent of genome size?

Thanks for your insights!
 Roland




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