[Employment-wanted] (no subject)

[abdelkrim alileche]

Oct 18, 2005

Dear Scientist

I am looking for a position

Here is my CV

My best regards
Dr ALILECHE



CURRICULUM VITAE
Updated October 18, 2005

ABDELKRIM ALILECHE

ADDRESS :
3300  16th Street  NW  Apt 104
Washington, DC  20010

Phone 202 687 2308

E-mail a_alileche at hotmail.com

Visa Status: H1-B visa valid for an other 6 to 8 years

CV

Medical studies and experience:

-October 1972 to October 1978 five years of medical studies at the Medicine 
faculty of Tunis
-October 1978 to October 1980 two years of intership: nuclear medicine, 
orthopedic surgery, internal medicine and nephrology,social medicine
-October 1981 to october 1982: military service in the tunisian army as a 
general practitionner
-April 1983 I became a medical doctor  MD
-August 1983 to august 1986 three years work as a GP in the Regional 
hospital of Nasrallah in Tunisia

Research Studies and experience

-September 1986 I moved to France to begin a 4 years training program in the 
INSERM Unite 268 directed by Pr Claude Jasmin at the Paul Brousse hospital 
in Villejuif France, this includes two years of studies in two universities: 
Paris Sud XIand Paris VII
-October 1991 I entered a PhD program in the Paris XI university . I worked 
with Pr Bruno Azzarone on the expression of the IL-2 receptor by non 
hematopoietic cells : human fibroblasts and human melanoma cells and its 
implications on IL-2 immunotherapy of human cancers.
-January 1994 I have obtained my PhD with honors
-March 1994 to 1998 postdoctoral fellowship with Dr TA Waldmann in the 
Metabolism Branch NCI, NIH. I worked on two projects:the development of a 
new model for the induction of the IL-2 receptor alpha chain by IL-2 and 
IL-15, the production of a monoclonal antibody against the human  IL-2 
receptor gamma chain
-April 1998 to february 2001 I worked with Pr CG Begley in the Bone 
MarrowResearch Laboratories ( an extension of the WEHI ) on the knoch out 
project of a new partner of the transcription factor SCL. The KO was 
embryonic
lethal.
-May 2002 to December 31, 2004   Post doc in the Microbiology and 
ImmunologyDepartment of the Albert Einstein College of Medicine in the 
Bronx, NY. with Dr Jurgen Brojatsch.

I worked on cell killing by anthrax toxin
-Feb 2005  until now I am a Post doc in Columbia University Molecular 
Medicine Dept. My supervisor is Dr Alessandra Pernis. I am working on IBP 
Knock out

My technical expertise covers many areas of molecular biology and 
biochemistry:the basics as:
Southern and Norhtern blots
PCR
Screening of genomic and cDNA libraries
Screning of BAC libraries
Mapping of genomic clones
KO and KI constructs
Western blot, Elisa
And also cellular biology including monoclonal antibody technology
Cell mutagenesis by ICR 191
FACS Analysis
CFSE Technique
Flow Jo Analysis

BIBLIOGRAPHY



1. ALILECHE A, SERFAS E, POECELLI S, BROJATSCH J
Anthrax toxin kills human and murine dendritic cells in vitro and in vivo
PLoS Pathogens  2005 In press

2. ALILECHE A, MUEHLBAUER S, BROJATSCH J
Proteasomal activity and a loss of ubiquitinated proteins are linked to 
anthrax toxin mediated killing of murine macrophages       JBC  2005 
Submitted

3.  BONUCELLI A, BROJATSCH J, ALILECHE A, LISANTI MP
Am J Physiol Cell Physiol 2005 Feb 2    Accepted

4. ALILECHE A , GOLDMAN CK , WALDMANN TA      The differential effects of 
IL-2 and IL-15 in the induction and expression of IL-2 receptor alpha chain  
       BBRC 2001 285 1302-91

5. ALILECHE A     The IL-2 immunotherapy of cancer : critical analysis of 
results, problems and expectations   Medical Hypothesis 2003, 60, 202-208

6. ALILECHE A , HAHN DS , AZZARONE B     IL-2 production by myofibroblasts 
from post radiation fibrosis in breast cancer patients     Int Immunology 
1994 6 1585



7. ALILECHE A , PLAISANCE S , AZZARONE B      Human melanoma cell line M14 
sectretes a functional IL-2      Oncogene 1993 8 1791

8. DAMJANOVITCH S , BENE L , MATKO J , ALILECHE A , WALDMANN TA     
Preassembly on interleukin 2 receptor subunits on resting kit 225 k6 T cells 
and their modulation by IL-2 , IL-7 and IL-15 : a fluorescence energy 
transfer study      PNAS 1997 94 13134

9. DOUCET C , MEAZZA R, POTTIN CLEMANCEAU C, SCUDELETTI M, BROUTY BOYE 
D,FERRINI S, ALILECHE A, INDIVERI F    Role of interleukin 2 and 15 in the 
progression of a melanoma cell line MEL P derived from an IL-2 progressor 
patient      Melanoma Res 1997 SUPPL 7 S7

10. SEMMEL M , ALILECHE A, JASMIN C     Inihibition of human 
immunodeficiency type 1 multiplication by an avian cellular factor     Arch 
Virology 1992 123 309

11. PLAISANCE S , ALILECHE A, AZZARONE B    How interleukin 2 can affect 
human fibroblast behaviour      Pathol Res Pract 1994 190 942

12. HAHN D , PLAISANCE S, RUBINSTEIN E, ALILECHE A, AZZARONE B    Non random 
activation of endogenous interleukin 2, interleukin 2 receptor alpha and 
interleukin 2 beta genes after transfection of mouse fibroblast with a cDNA 
for the alpha chain of the human intereleukin 2 receptor   Eur J Immunology 
1995 25 1905

13. KRIEF P , LAWRENCE D, ALILECHE A, SEMMEL M    Purification and 
characterization of a factor which inhibits retrovirus replication    Res 
Virology 1995 146 113

14. SEMMEL M , MACHO A, COULAUD D, ALILECHE A, JASMIN C    Effect of 
retinoic acidon HL60 cells infected with human immunodeficiency type 1     
Blood 1994 84 2480

15. PLAISANCE S , RUBINSTEIN E, ALILECHE A, AZZARONE B     Human melanoma 
cells express a functional interleukin 2 receptor      Int J Cancer 1993 55 
164

16. PLAISANCE S , RUBINSTEIN E, ALILECHE A, AZZARONE B     The interleukin 2 
receptor present on human embryonic fibroblast is functional in the absence 
of p64 interleukin 2 receptor gamma chain      Int Immunology 1993 5 843

17. SEMMEL M , MACHO A, MOROZOV V, COULAUD D, ALILECHE A, JASMIN C    
Replication of human immunodeficiency virus in HL60 cells     Res Virology 
1992 143 249

18. PLAISANCE S , RUBINSTEIN E, ALILECHE A, AZZARONE B     Expression of the 
interleukin 2 receptor on human fibroblast and its biological significance
Int Immunology 1992 4 739

19. BEN JAAFAR M , ELLOUZ R, ALILECHE A     Radioscintigraphic corelation in 
the diagnosis of bone metastasis of cancer of nasopharynx   Tunisie Medicale 
1982 60 33



If you want to talk to my referees, please feel free to do it. Here are
their addresses

1. Dr TA Waldmann
Chief Metabolism Branch NIH NCI
Bldg 10 Room 4N115 9000 Rockville Pike
Bethesda MD 20892 USA
Phone 301 496 6653
E-mail twald at helix.nih.gov

2. Professor Glenn Begley
Amgen      One Amgen Center Drive, Mail Drop 15-2-B
Thousand Oaks, CA 91320-1799
Tel 1 (805) 447 4431
Email glenn.begley at amgen.com

3.  Pr Bruno Azzarone
INSERM UNITE 268     Hopital Paul Brousse 14 Avenue Paul Vaillant Couturier
94700 Villejuif France
Phone 33 1 4559 3757
E-mail bazzarone at hotmail.com

4.  Dr Jurgen Brojatsch
Albert Einstein College of Medicine
Department of Microbiology and Immunology      1300 Morris Parc Ave    Room 
G404
Bronx NY 10461 USA
Phone 1 718 430 3079
E-mail Brojatsch at aecom.yu.edu