Any cis peptides out there......

CS Raman raman at HEMEBASE.BIO.UCI.EDU
Sun Apr 5 19:26:19 EST 1998


Mark:

{*} I have a non-proline cis-peptide bond in a structure i've recently 
{*} determined, and would like to know how many other's there are.
{*} 
{*} Has anyone compiled a list of protein structures containing such bonds?
{*} Or have any idea how i could go about compiling such a list? I've been
{*} unable to design a database search for these bond types, without calling
{*} up all the cis-prolines.

Take a look at the work of Stewart & colleagues from Georgia:

Stewart DE; Sarkar A; Wampler JE.
Occurrence and role of cis peptide bonds in protein structures.
Journal of Molecular Biology, 1990 Jul 5, 214(1):253-60.

Some interesting ones that come to my mind are:

RNAse T1
Beta lactamase
Carbonic anhydrase
Dihydrofolate Reductase

Cheers
-raman
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C.S.Raman                    Tel: (714) 824-4322
University of California     Fax: (714) 824-3280
Dept. MB & B, SH530          email: craman at uci.edu
3205 Bio Sci II
Irvine, CA 92697-3900
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