Torsion angle dynamics and DNA

Barry Schweitzer barry at SNEEZY.FHIS.NET
Thu Mar 5 17:15:44 EST 1998


Hi All!

I have been attempting to obtain a structure of a DNA duplex
using torsion angle dynamics (TAD).  With a fair bit of work, I have
been able to get some reasonable structures, but like the 
original paper by Stein et al., the success rate is low.  
Considering the lack of long-range restraints, this does
not surprise me, but I would be interested to hear if others 
have tried TAD with DNA and what their experiences have been.

BTW, we have also used TAD on proteins with great success!

Cheers,

Barry

Barry Schweitzer, Ph.D.
Director
Division of Molecular & Structural Biology
Walt Disney Memorial Cancer Institute
12722 Research Parkway
Orlando, FL  32826
Phone: 407-380-9977
FAX:     407-380-9978




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