any cis peptides out there ...

Manfred Weiss msweiss at imb-jena.de
Mon Mar 9 10:46:48 EST 1998


Hi Mark,

we have recently found two non-proline cis peptide
bonds in coagulation factor XIII. One is close to the
active site (Arg-Tyr) and the other one is at the
dimerization interface of the homodimer (Gln-Phe).
Sequence comparisons suggest that these are 
conserved. See our paper in FEBS Lett. 423, 291-296 (1998).

Best wishes,

   Manfred Weiss



Mark Banfield writes:

> 
> Hi,
> 
> I have a non-proline cis-peptide bond in a structure i've recently 
> determined, and would like to know how many other's there are.
> 
> Has anyone compiled a list of protein structures containing such bonds?
> Or have any idea how i could go about compiling such a list? I've been
> unable to design a database search for these bond types, without calling
> up all the cis-prolines.
> 
> Thanks for any help.....
> 
> Mark Banfield
> 
> Dept. of Biochem.
> University of Bristol
> Bristol
> UK
> 
> 


-- 

   Manfred S. Weiss, Dr.
   Institute of Molecular Biotechnology
   Department of Structural Biology and Crystallography
   Beutenbergstrasse 11         
   Postfach 100813                                   Phone: +49-3641-65-6070
   D-07708 Jena                                      Fax:   +49-3641-65-6062
   GERMANY                                           Email: msweiss at imb-jena.de






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