NMR Postdoctoral Positions

Yi Zhu yizhu at kringle.bri.nrc.ca
Tue Oct 13 15:04:22 EST 1998




Two NMR Postdoctoral Positions:
(available after January, 1999)

(1) Solution Structure and Conformational Stability of Protein-Ligand Complexes
(2) Conformational Dynamics of Bioactive Peptides

The Biomolecular NMR laboratory of the Biotechnology Research Institute 
(BRI) has two postdoctoral openings in Biomolecular NMR.  The first position 
will have the work centered on NOE assignment/structure calculations, NMR 
relaxation measurements, and meaurements of ligand exchange rates.  The 
second position will focus on peptide conformational analysis, measurement 
of proton relaxation rates, and NMR-based conformational searches.  Ideal 
candidates should have a recent Ph.D. in chemistry, biochemistry or a related 
discipline, and have prior experience in at least one or two areas of the 
planned research projects.

The mandate of the Biomolecular NMR Group at BRI is to carry out research 
into the structure, molecular interactions and design of mimetics within 
protein systems that are strategic targets for pharmaceutical development.  
The core of our work is the use of multi-dimensional NMR to determine the 
bioactive conformations of peptides and protein fragments and to establish 
their modes of binding with protein targets.  Research projects are focused 
on the following areas: 

   (1) dissection of regulatory protease-inhibitor/cofactor functional 
       interfaces; 
   (2) minimization and mimetics design of the EGF- and granulin-like 
       protein repeats; 
   (3) interactions of kinase and phosphatase domains with their protein 
       targets; 
   (4) solution conformations of human parathyroid hormone (PTH) and 
       antibody (VH) fragments; 
   (5) methods for the structural characterization of protein-ligand complexes.

The primary goal of our research is to elucidate the molecular determinants 
of the selective interactions of bioactive peptides and proteins and to 
assist the design of functional mimetics of protein-protein interactions.  
Our NMR work is supported by a 500 MHz NMR spectrometer and by shared use 
with external clients of a second 500 MHz NMR spectrometer and of an 800 MHz 
very-high-field NMR facility (established in 1997).

The salary for postdoctoral fellows is at the standard MRC rate of 
CND$ 24,000-27,000/year commensurate with experience.  Successful 
candidates are encouraged to apply for the NSERC visiting fellowships in 
NRC laboratories which offer a competitive salary of $36,000/year plus 
some relocation expenses.  Interested candidates should send their CVs 
and arrange for two letters of references sent to:

	Dr. Feng Ni
	Group Leader, Biomolecular NMR
	Biotechnology Research Institute
	6100 Royalmount Avenue
	Montreal, Quebec
	Canada H4P 2R2

or contact Dr. Feng Ni at:

	Phone: (514)-496-6729; Fax: (514)-496-5143
	e_mail:  Feng.Ni at nrc.ca




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