Searching a sequence in Brookhaven Protein Data Bank...

CZJ at CU.NIH.GOV CZJ at CU.NIH.GOV
Tue Mar 2 08:40:16 EST 1993


> In article <111738 at netnews.upenn.edu> duong at chestnut.chem.upenn.edu (Duc Duong) writes:
> >[Is] "one sequence one structure" [] correct or not...
>
> Among many other examples, two states of hemoglobin prove that proteins don't
> have a single structure for a given sequence.
>
>   Tom Schneider
>   National Cancer Institute
>   Laboratory of Mathematical Biology
>   Frederick, Maryland  21702-1201
>   toms at ncifcrf.gov
>
>

All the hemoglobin analogy proves is that you cannot ignore
the prosthetic group.  The two different protein conformations
are determined by the change in the structure of the prosthetic group
on oxygenation.

Jim Cassatt





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