Protein conformations

sun at vger.niddk.nih.gov sun at vger.niddk.nih.gov
Thu Mar 4 22:26:25 EST 1993


        There is an good example in a mutant of T4 lysozyme where five
different conformations of the protein have been seen in one crystal form.
The difference between the five conformations is mainly to do with a hinge
motion that locates in between the N and C terminal domain (correction:
four conformations in this crystal form and one in a different crystal form).
The hinge angle varies from 9 to 30 degrees. As a result, each individual
domain can be superimposed but not both simultaneously.  The work was
published in Nature vol 348, 263-266,1990 by H.R. Faber and B.W. Matthews.
                                Sun Daopin




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