1994 CSHL Macromolecular Crystallography Course

[Jim Pflugrath in Pflugrath Lab]

                1994 Macromolecular Crystallography Course
                           October 13-26, 1994
   
                       Cold Spring Harbor Laboratory
                       Cold Spring Harbor, NY  11724

Organizers:

            Alex McPherson, University of California, Riverside
            William Furey, Veterans Administration Medical Center, Pittsburgh
            Gary Gilliland, Center for Advanced Research in Biotechnology
            James Pflugrath, Cold Spring Harbor Laboratory

Some of the confirmed speakers are:

            Axel Brunger,  Yale University
            Paula Fitzgerald, Merck Research Laboratories
            Stephen Harrison, Harvard University
            Morten Kjeldgaard, Aarhus University
            John Kuriyan, Rockefeller University
            Janet Smith, Purdue University
            Robert Sweet, Brookhaven National Laboratory
            Dale Tronrud, University of Oregon

with more to be added ...

Tuition, Room and Board:  $1,660

Crystallography and X-ray diffraction yield a wealth of structural
information unobtainable through other methods.  This **intensive** laboratory/
computational course will focus on the major techniques used to determine
the three-dimensional structures of macromolecules.  It is designed for 
scientists with a working knowledge of protein structure and function, but who
are new to macromolecular crystallography.  Topics that will be covered
include crystallization, crystal characterization, X-ray sources and optics,
data collection, data reduction, anomalous dispersion, multiple isomorphous
replacement, phase determination, solvent flattening, molecular replacement 
and averaging, electron density interpretation, structure refinement, 
molecular graphics, molecular dynamics and multi-dimensional NMR.
Participants will learn through extensive hands-on experiments where they
will crystallize and determine a protein structure, along with lectures
and informal discussions on the theory behind the techniques.

The course is limited to 16 participants.

Partial scholarships are available for those participants with 
demonstrated financial need (no one has yet received a full scholarship).
For more information and an application please contact:

Course Registrar
Cold Spring Harbor Laboratory
1 Bungtown Road
Cold Spring Harbor, NY 11724-2213
Fax:    (516) 367-8845
Phone:  (516) 367-8345
E-mail: meetings at cshl.org

Application deadline:  July 15, 1994