HMG Protein Structure

BG9000 bg9000 at
Sat Oct 1 19:36:06 EST 1994

Has anyone out there tried to crystalize HMG I or HMG II ?
These are small nuclear DNA binding proteins that have been implicated as
transcription initiation factors as well as flags for certain types of DNA
damage.  A partial structure of the DNA binding region (the HGM box) has
been solved using NMR techniques by Jean Thomas and others.  These
proteins are relatively easy to purify and I am wondering if anyone has
attempted to crystallize them.
Any information on HMG structure analysis would be appreciated.

Jeff Taylor
Dept of Structural Biology and Biophysics
University of Pennsylvania

More information about the Xtal-log mailing list