Releasing coordinates

harrison at calvin.jci.tju.eduRobertW.Harrison harrison at calvin.jci.tju.eduRobertW.Harrison
Wed Sep 14 12:15:18 EST 1994

In article <199409130243.TAA29239 at>, LOLL at BIOVAX.UCHICAGO.EDU writes:
|> >  David Mueller writes:
|> >What is considered an acceptable time to release
|> >the coordinates of the crystal structure of
|> >a protein  - relative to the time that the
|> >structure is published?  What is considered
|> >an unacceptable amount of time?  Are there
|> >any standards?
|> First, the ONLY acceptable course upon publishing
|> is to deposit the coordinates.  Now, I believe
|> that it's perfectly reasonable to place a hold on 
|> the coords for, say 18 months after deposition
|> (and deposition will coincide roughly with
|> publishing).  This gives the small labs a
|> head start during which they can reap the 
|> hard-won fruits of their structure (for example,
|> determine the structures of enzyme-drug complexes
|> or of different isoforms).  Were this not 
|> possible, one can imagine scenarios wherein
|> large aggressive labs could snarf up the 
|> coordinates from the PDB and use the phases
|> calculated there from to churn out a 
|> gazillion variants of the structure in short
|> order.  This might easily squelch any 
|> further work by the originating lab,.  You can
|> imagine that small labs may well be incapable of
|> investing the years of groundwork required to 
|> establish a system if they can only get on
|> structure from that system.
|> 	Of course, decency and courtesy require
|> that investigators release the coordinates
|> earlier to folks with strong vested interests
|> (eg, enzymologists who are working on a 
|> particular enzyme).  One way to do this is
|> to simply require that they use them only in
|> their own lab and don't release them without
|> your permission.
|> 	I'd be curious to hear other folks' 
|> opinions of this.
|> Pat Loll
|> Univ. of Chicago
|> loll at

So what do you do about the clown who reviews your
grant, likes the idea, snuffs the grant, and asks
for the coordinates?  AS HAS HAPPENED to me.

By the way i generally agree that releasing 
coordinates is a good idea, and have released
all of the recent ones from my lab.
					robert w. harrison
					harrison at

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