postdoctoral research positions: AIDS drug & vaccine design, structural studies

ARNOLD at OCELOT.RUTGERS.EDU ARNOLD at OCELOT.RUTGERS.EDU
Mon Apr 10 09:10:36 EST 1995


POSTDOCTORAL POSITIONS: CRYSTALLOGRAPHIC ANALYSIS OF AND STRUCTURE-BASED DRUG
DESIGN AGAINST THE AIDS VIRUS REVERSE TRANSCRIPTASE & AIDS VACCINE DEVELOPMENT
USING GENETICALLY ENGINEERED HUMAN RHINOVIRUSES

Highly motivated researchers are sought to participate in crystallographic
structure determination and refinement of HIV-1 reverse transcriptase (RT) with
bound nucleic acids and inhibitors at high resolution (in collaboration with the
laboratory of Stephen Hughes at NCI-Frederick).  We have solved the structures
of HIV-1 RT with dsDNA (3.0 A structure: PNAS 90:6320-6324, 1993; 2.8 A
refinement in progress) and inhibitors (e.g., RT/a-APA inhibitor complex:
Structure 3:365-379, 1995; RT/TIBO complex: Nature Structural Biology, in
press).  We are also undertaking structural and biochemical studies of RT bound
with different dsDNA duplexes, RNA-DNA template-primers, and additional
inhibitors, as well as drug-resistant mutants of HIV-1 RT.  Researchers are also
sought for vaccine engineering of human rhinoviruses to display immunogens from
other pathogens, with a current focus on HIV-1 (J. Virol. 68:575-579, 1994; J.
Virol., 69:2406-2411, 1995).  Preliminary efficacy of our chimeric human
rhinovirus vaccine approach has been demonstrated in that antisera raised
against human rhinovirus:HIV hybrids can neutralize HIV in cell culture. 
Crystals of several of the human rhinovirus:HIV chimeras have been obtained and
we are currently determining the structure of the first of these.  A strong
background in crystallography, chemistry, biochemistry, virology, or molecular
biology is required.  Our laboratory at the Center for Advanced Biotechnology
and Medicine (CABM) has state-of-the-art facilities for crystallography, protein
chemistry, molecular biology, virology, and molecular modeling.  AA/EOE,
m/f/h/v.  Send CV and names and addresses of three references to:

Eddy Arnold and/or Gail Ferstandig Arnold, 
CABM and Rutgers University,  679 Hoes Lane,
Piscataway, NJ  08854-5638.  
Phones: (908) 235-5323 and/or 235-4343;  FAX: (908) 235-4850.  
E-mail: arnold at rhino.cabm.rutgers.edu and/or gfarnold at mbcl.rutgers.edu




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